Susan Rowell, Eric N Meier, Tatiana Hoyos Gomez, Michael Fleming, Jon Jui, Laurie Morrison, Eileen Bulger, George Sopko, Myron Weisfeldt, Jim Christenson, Pat Klotz, Jason McMullan, Jeannie Callum, Kellie Sheehan, Brian Tibbs, Tom Aufderheide, Bryan Cotton, Rajesh Gandhi, Ahamed Idris, Ralph J Frascone, Michael Ferrara, Neil Richmond, Delores Kannas, Rob Schlamp, Bryce Robinson, David Dries, John Tallon, Audrey Hendrickson, Mark Gamber, John Garrett, Robert Simonson, W Ian McKinley, Martin Schreiber
BACKGROUND: In the Prehospital Tranexamic Acid (TXA) for TBI Trial, TXA administered within two hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic brain injury (TBI). We examined the association between TXA dosing arms, neurologic outcome, and mortality in patients with intracranial hemorrhage (ICH) on computed tomography (CT). METHODS: This was a secondary analysis of the Prehospital Tranexamic Acid for TBI Trial (ClinicalTrials...
April 30, 2024: Journal of Trauma and Acute Care Surgery