Majke H D van Bommel, Miranda P Steenbeek, Joanna IntHout, Rosella P M G Hermens, Nicoline Hoogerbrugge, Marline G Harmsen, Helena C van Doorn, Marian J E Mourits, Marc van Beurden, Ronald P Zweemer, Katja N Gaarenstroom, Brigitte F M Slangen, Monique M A Brood-van Zanten, M Caroline Vos, Jurgen M Piek, Luc R C W van Lonkhuijzen, Mirjam J A Apperloo, Sjors F P J Coppus, Judith B Prins, José A E Custers, Joanne A de Hullu
OBJECTIVE: High cancer risks, as applicable to BRCA1 and BRCA2 pathogenic variant (PV) carriers, can induce significant cancer concerns. We examined the degree of cancer worry and the course of this worry among BRCA1/2-PV carriers undergoing surgery to prevent ovarian cancer, and identified factors associated with high cancer worry. METHODS: Cancer worry was evaluated as part of the multicentre, prospective TUBA-study (NCT02321228) in which BRCA1/2-PV carriers choose either novel risk-reducing salpingectomy with delayed oophorectomy or standard risk-reducing salpingo-oophorectomy...
April 2022: Supportive Care in Cancer