Miranda P Steenbeek, Marline G Harmsen, Nicoline Hoogerbrugge, Marieke Arts de Jong, Angela H E M Maas, Judith B Prins, Johan Bulten, Steven Teerenstra, Majke H D van Bommel, Helena C van Doorn, Marian J E Mourits, Marc van Beurden, Ronald P Zweemer, Katja N Gaarenstroom, Brigitte F M Slangen, Monique M A Brood-van Zanten, M Caroline Vos, Jurgen M J Piek, Luc R C W van Lonkhuijzen, Mirjam J A Apperloo, Sjors F P J Coppus, Leon F A G Massuger, Joanna IntHout, Rosella P M G Hermens, Joanne A de Hullu
Importance: Most women with a BRCA1/2 pathogenic variant undergo premature menopause with potential short- and long-term morbidity due to the current method of ovarian carcinoma prevention: risk-reducing salpingo-oophorectomy (RRSO). Because the fallopian tubes play a key role in ovarian cancer pathogenesis, salpingectomy with delayed oophorectomy may be a novel risk-reducing strategy with benefits of delaying menopause. Objective: To compare menopause-related quality of life after risk-reducing salpingectomy (RRS) with delayed oophorectomy with RRSO in carriers of the BRCA1/2 pathogenic variant...
June 3, 2021: JAMA Oncology