Cindy Audiger, Yacine Laâbi, Junli Nie, Leonie Gibson, Julie Wilson-Annan, Phillip Brook-Carter, Andrew Kueh, Alan W Harris, Shalin Naik, Stephen L Nutt, Andreas Strasser, Jerry M Adams, Philippe Bouillet, Michaël Chopin
The traditional view of hematopoiesis is that myeloid cells derive from a common myeloid progenitor (CMP), whereas all lymphoid cell populations, including B, T, and natural killer (NK) cells and possibly plasmacytoid dendritic cells (pDCs), arise from a common lymphoid progenitor (CLP). In Max41 transgenic mice, nearly all B cells seem to be diverted into the granulocyte lineage. Here, we show that these mice have an excess of myeloid progenitors, but their CLP compartment is ablated, and they have few pDCs...
April 26, 2024: Cell Reports