Hai Xin, Ben M Ferguson, Boyang Wan, D S Abdullah Al Maruf, William T Lewin, Kai Cheng, Hedi V Kruse, David Leinkram, Krishnan Parthasarathi, Innes K Wise, Catriona Froggatt, Jeremy M Crook, David R McKenzie, Qing Li, Jonathan R Clark
The present work describes a preclinical trial ( in silico , in vivo and in vitro ) protocol to assess the biomechanical performance and osteogenic capability of 3D-printed polymeric scaffolds implants used to repair partial defects in a sheep mandible. The protocol spans multiple steps of the medical device development pipeline, including initial concept design of the scaffold implant, digital twin in silico finite element modeling, manufacturing of the device prototype, in vivo device implantation, and in vitro laboratory mechanical testing...
May 2, 2024: ACS Biomaterials Science & Engineering