Magdalena Wójcik, Ulana Juhas, Elyas Mohammadi, Jonas Mattisson, Kinga Drężek-Chyła, Edyta Rychlicka-Buniowska, Bożena Bruhn-Olszewska, Hanna Davies, Katarzyna Chojnowska, Paweł Olszewski, Michał Bieńkowski, Michał Jankowski, Olga Rostkowska, Andrzej Hellmann, Rafał Pęksa, Jacek Kowalski, Marek Zdrenka, Jarek Kobiela, Wojciech Zegarski, Wojciech Biernat, Łukasz Szylberg, Piotr Remiszewski, Jakub Mieczkowski, Natalia Filipowicz, Jan P Dumanski
Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved in oncogenesis. Previous studies show that LOY in circulating leukocytes of aging men was associated with shorter survival and non-hematological cancer, as well as higher LOY in CD4 + T-lymphocytes in men with prostate cancer vs. controls. However, nothing is known about LOY in leukocytes infiltrating TME and we address this aspect here...
April 24, 2024: Scientific Reports