Wei Sun, Fan Yang, Yan Wang, Yan Yang, Rui Du, Xiao-Liang Wang, Zhi-Xin Luo, Jun-Jie Wu, Jun Chen
Neuropathic pain can occur during the prediabetic stage, even in the absence of hyperglycemia. The presence of prediabetic neuropathic pain (PDNP) poses challenges to the management of individuals with prediabetes. However, the mechanisms underlying this pain remain unclear. This study aims to investigate the underlying mechanism and identify potential therapeutic targets of PDNP. A prediabetic animal model induced by a high-energy diet exhibits both mechanical allodynia and thermal hyperalgesia. Furthermore, hyperexcitability and decreased potassium currents are observed in the dorsal root ganglion (DRG) neurons of these rats...
April 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)