Jiahe Liao, Xinbo Yu, Ziwei Huang, Qian He, Jianying Yang, Yan Zhang, Jiaqi Chen, Weijiang Song, Jing Luo, Qingwen Tao
Sjögren's syndrome (SS) is a chronic systemic autoimmune disease that typically presents with lymphocyte, dendritic cell, and macrophage infiltration of exocrine gland ducts and the formation of ectopic germinal centers. The interactions of lymphocyte homing receptors and addressins and chemokines and their receptors, such as α4β7/MAdCAM-1, LFA-1/ICAM-1, CXCL13/CXCR5, CCL25/CCR9, CX3CL1/CX3CR1, play important roles in the migration of inflammatory cells to the focal glands and the promotion of ectopic germinal center formation in SS...
2024: Frontiers in Immunology