Nick Corriveau-Lecavalier, Leland R Barnard, Hugo Botha, Jonathan Graff-Radford, Vijay K Ramanan, Jeyeon Lee, Ellen Dicks, Rosa Rademakers, Bradley F Boeve, Mary M Machulda, Julie A Fields, Dennis W Dickson, Neill Graff-Radford, David S Knopman, Val J Lowe, Ronald C Petersen, Clifford R Jack, David T Jones
There is a longstanding ambiguity regarding the clinical diagnosis of dementia syndromes predominantly targeting executive functions versus behavior and personality. This is due to an incomplete understanding of the macro-scale anatomy underlying these symptomatologies, a partial overlap in clinical features, and the fact that both phenotypes can emerge from the same pathology and vice-versa. We collected data from a patient cohort of which 52 had dysexecutive Alzheimer's disease, 30 had behavioral variant frontotemporal dementia, seven met clinical criteria for behavioral variant frontotemporal dementia but had Alzheimer's disease pathology (behavioral Alzheimer's disease), and 28 had amnestic Alzheimer's disease...
October 13, 2023: Brain