Yueh Chien, Xuan-Yang Huang, Aliaksandr A Yarmishyn, Chian-Shiu Chien, Yu-Hao Liu, Yu-Jer Hsiao, Yi-Ying Lin, Wei-Yi Lai, Ssu-Cheng Huang, Meng-Shiue Lee, Shih-Hwa Chiou, Yi-Ping Yang, Guang-Yuh Chiou
Coronaviruses (CoVs) are enveloped single-stranded RNA viruses that predominantly attack the human respiratory system. In recent decades, several deadly human CoVs, including SARS-CoV, SARS-CoV-2, and MERS-CoV, have brought great impact on public health and economics. However, their high infectivity and the demand for high biosafety level facilities restrict the pathogenesis research of CoV infection. Exacerbated inflammatory cell infiltration is associated with poor prognosis in CoV-associated diseases. In this study, we used human CoV 229E (HCoV-229E), a CoV associated with relatively fewer biohazards, to investigate the pathogenesis of CoV infection and the regulation of neutrophil functions by CoV-infected lung cells...
May 17, 2024: Virus Research