Jianjun Zhang, Xin Hu, Bo Zhu, Natalie Vokes, Junya Fukuoka, Frank Rojas Alvarez, Simon Heeke, Andre Moreira, Luisa Solis, Cara Haymaker, Vamsidhar Velcheti, Daniel Sterman, Harvey Pass, Chao Cheng, Jack Lee, Jianhua Zhang, Zhubo Wei, Jia Wu, Xiuning Li, Edwin Ostrin, Iakovos Toumazis, Don Gibbons, Dan Su, Junya Fukuoka, Mara Antonoff, David Gerber, Chenyang Li, Humam Kadara, Linghua Wang, Mark Davis, John Heymach, Samir Hanash, Ignacio Wistuba, Steven Dubinett, Ludmil Alexandrov, Scott Lippman, Avrum Spira, Andrew Futreal, Alexandre Reuben
Studying lung adenocarcinoma (LUAD) early carcinogenesis is challenging, primarily due to the lack of LUAD precursors specimens. We amassed multi-omics data from 213 LUAD and LUAD precursors to identify molecular features underlying LUAD precancer evolution. We observed progressively increasing mutations, chromosomal aberrations, whole genome doubling and genomic instability from precancer to invasive LUAD, indicating aggravating chromosomal instability (CIN). Telomere shortening, a crucial genomic alteration linked to CIN, emerged at precancer stage...
May 15, 2024: Research Square