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JOURNAL ARTICLE
Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza
BACKGROUND/AIM: Protein phosphatase and tensin homolog (PTEN) is a tumor suppressor protein with potential to be a new biotechnological drug for PTEN-deficient cancer treatment. This study aimed to develop PTEN-based chimeric proteins (CPP-PTEN-THP) for human epidermal growth factor receptor 2 (HER2)-positive breast cancer treatment, addressing current limitations like inadequate delivery, poor tumor penetration, and low selectivity, while assessing their potential HER2-specific anticancer effects...
June 2024: Anticancer Research
#2
JOURNAL ARTICLE
Giulia Sbrini, Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Cristina Missale, Chiara Fiorentini
Dopaminergic neurons express an heteromer composed of the dopamine D3 receptor and the α4-β2 nicotinic acetylcholine receptor, the D3R-nAChR heteromer, activated by both nicotine and dopamine D2 and D3 receptors agonists, such as quinpirole, and crucial for dopaminergic neuron homeostasis. We now report that D3R-nAChR heteromer activity is potentiated by 17-β-estradiol which acts as a positive allosteric modulator by binding a specific domain on the α4 subunit of the nicotinic receptor protomer...
May 29, 2024: European Journal of Pharmacology
#3
JOURNAL ARTICLE
Anne Miller, Rachel Daum, Tao Wang, Mengfen Wu, Candise Tat, Thomas Pfeiffer, Shoba Navai, Andras Heczey, Meenakshi Hegde, Nabil Ahmed, Sarah B Whittle, LaQuisa Hill, Caridad Martinez, Robert Krance, Carlos A Ramos, Rayne H Rouce, Premal Lulla, Helen E Heslop, Bilal Omer, Meghan Shekar
BACKGROUND AIMS: The success of chimeric antigen receptor (CAR) T-cell therapy in treating B-cell malignancies has led to the evaluation of CAR T-cells targeting a variety of other malignancies. Although the efficacy of CAR T-cells is enhanced when administered post-lymphodepleting chemotherapy, this can trigger bone marrow suppression and sustained cytopenia after CD19.CAR T-cell therapy. Additionally, systemic inflammation associated with CAR T-cell activity may contribute to myelosuppression...
May 8, 2024: Cytotherapy
#4
Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Schöndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashuel
No abstract text is available yet for this article.
May 30, 2024: Nature Communications
#5
JOURNAL ARTICLE
Theresa H Tam, Wenbo Zhang, YuShan Tu, Janice L Hicks, Sophia Farcas, Doyeon Kim, Michael W Salter
Chronic pain is associated with alterations in fundamental cellular processes. Here, we investigate whether Beclin 1, a protein essential for initiating the cellular process of autophagy, is involved in pain processing and is targetable for pain relief. We find that monoallelic deletion of Becn1 increases inflammation-induced mechanical hypersensitivity in male mice. However, in females, loss of Becn1 does not affect inflammation-induced mechanical hypersensitivity. In males, intrathecal delivery of a Beclin 1 activator, tat-beclin 1, reverses inflammation- and nerve injury-induced mechanical hypersensitivity and prevents mechanical hypersensitivity induced by brain-derived neurotrophic factor (BDNF), a mediator of inflammatory and neuropathic pain...
May 29, 2024: Cell Reports
#6
JOURNAL ARTICLE
Weifen Li, Qichao Gong, Wenhui Zhu, Tahir Ali, Zhi-Jian Yu, Shupeng Li, Xiaoming Yu
Genetic knockout and pharmaceutical inhibition of the NLRP3 inflammasome enhances the extinction of contextual fear memory, which is attributed to its role in neuronal and synaptic dysregulation, concurrent with neurotransmitter function disturbances. This study aimed to determine whether NLRP3 plays a role in generalizing fear via the inflammatory axis. We established the NLRP3 KO mice model, followed by behavioral and biochemical analyses. The NLRP3 KO mice displayed impaired fear generalization, lower neuroinflammation levels, and dysregulated neurotransmitter function...
May 23, 2024: Biochemical and Biophysical Research Communications
#7
JOURNAL ARTICLE
Seong Yun Lee, Junyoung Park, Sang Beom Seo
BACKGROUND: Colon cancer is the third most common cancer globally. The expression of histone deacetylase 3 (HDAC3) is upregulated, whereas the expression of tat interactive protein, 60 kDa (TIP60) is downregulated in colon cancer. However, the relationship between HDAC3 and TIP60 in colon cancer has not been clearly elucidated. OBJECTIVE: We investigated whether TIP60 could regulate the expression of HDAC3 and suppress colon cancer cell proliferation. METHODS: RNA sequencing data (GSE108834) showed that HDAC3 expression was regulated by TIP60...
May 28, 2024: Genes & Genomics
#8
JOURNAL ARTICLE
M Ablikim, M N Achasov, P Adlarson, X C Ai, R Aliberti, A Amoroso, M R An, Q An, Y Bai, O Bakina, I Balossino, Y Ban, V Batozskaya, K Begzsuren, N Berger, M Berlowski, M Bertani, D Bettoni, F Bianchi, E Bianco, A Bortone, I Boyko, R A Briere, A Brueggemann, H Cai, X Cai, A Calcaterra, G F Cao, N Cao, S A Cetin, J F Chang, T T Chang, W L Chang, G R Che, G Chelkov, C Chen, Chao Chen, G Chen, H S Chen, M L Chen, S J Chen, S M Chen, T Chen, X R Chen, X T Chen, Y B Chen, Y Q Chen, Z J Chen, W S Cheng, S K Choi, X Chu, G Cibinetto, S C Coen, F Cossio, J J Cui, H L Dai, J P Dai, A Dbeyssi, R E de Boer, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, B Ding, X X Ding, Y Ding, Y Ding, J Dong, L Y Dong, M Y Dong, X Dong, M C Du, S X Du, Z H Duan, P Egorov, Y L Fan, J Fang, S S Fang, W X Fang, Y Fang, R Farinelli, L Fava, F Feldbauer, G Felici, C Q Feng, J H Feng, K Fischer, M Fritsch, C Fritzsch, C D Fu, J L Fu, Y W Fu, H Gao, Y N Gao, Yang Gao, S Garbolino, I Garzia, P T Ge, Z W Ge, C Geng, E M Gersabeck, A Gilman, K Goetzen, L Gong, W X Gong, W Gradl, S Gramigna, M Greco, M H Gu, Y T Gu, C Y Guan, Z L Guan, A Q Guo, L B Guo, M J Guo, R P Guo, Y P Guo, A Guskov, T T Han, W Y Han, X Q Hao, F A Harris, K K He, K L He, F H H Heinsius, C H Heinz, Y K Heng, C Herold, T Holtmann, P C Hong, G Y Hou, X T Hou, Y R Hou, Z L Hou, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, K X Huang, L Q Huang, X T Huang, Y P Huang, T Hussain, N Hüsken, W Imoehl, M Irshad, J Jackson, S Jaeger, S Janchiv, J H Jeong, Q Ji, Q P Ji, X B Ji, X L Ji, Y Y Ji, X Q Jia, Z K Jia, H J Jiang, L L Jiang, P C Jiang, S S Jiang, T J Jiang, X S Jiang, Y Jiang, J B Jiao, Z Jiao, S Jin, Y Jin, M Q Jing, T Johansson, X Kui, S Kabana, N Kalantar-Nayestanaki, X L Kang, X S Kang, R Kappert, M Kavatsyuk, B C Ke, A Khoukaz, R Kiuchi, R Kliemt, O B Kolcu, B Kopf, M K Kuessner, A Kupsc, W Kühn, J J Lane, P Larin, A Lavania, L Lavezzi, T T Lei, Z H Lei, H Leithoff, M Lellmann, T Lenz, C Li, C Li, C H Li, Cheng Li, D M Li, F Li, G Li, H Li, H B Li, H J Li, H N Li, Hui Li, J R Li, J S Li, J W Li, K L Li, Ke Li, L J Li, L K Li, Lei Li, M H Li, P R Li, Q X Li, S X Li, T Li, W D Li, W G Li, X H Li, X L Li, Xiaoyu Li, Y G Li, Z J Li, Z X Li, C Liang, H Liang, H Liang, H Liang, Y F Liang, Y T Liang, G R Liao, L Z Liao, Y P Liao, J Libby, A Limphirat, D X Lin, T Lin, B J Liu, B X Liu, C Liu, C X Liu, F H Liu, Fang Liu, Feng Liu, G M Liu, H Liu, H B Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J L Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L Liu, L C Liu, Lu Liu, M H Liu, P L Liu, Q Liu, S B Liu, T Liu, W K Liu, W M Liu, X Liu, Y Liu, Y Liu, Y B Liu, Z A Liu, Z Q Liu, X C Lou, F X Lu, H J Lu, J G Lu, X L Lu, Y Lu, Y P Lu, Z H Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, Y F Lyu, F C Ma, H L Ma, J L Ma, L L Ma, M M Ma, Q M Ma, R Q Ma, R T Ma, X Y Ma, Y Ma, Y M Ma, F E Maas, M Maggiora, S Malde, Q A Malik, A Mangoni, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, H Miao, T J Min, R E Mitchell, X H Mo, N Yu Muchnoi, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, Y Niu, S L Olsen, Q Ouyang, S Pacetti, X Pan, Y Pan, A Pathak, P Patteri, Y P Pei, M Pelizaeus, H P Peng, K Peters, J L Ping, R G Ping, S Plura, S Pogodin, V Prasad, F Z Qi, H Qi, H R Qi, M Qi, T Y Qi, S Qian, W B Qian, C F Qiao, J J Qin, L Q Qin, X P Qin, X S Qin, Z H Qin, J F Qiu, S Q Qu, C F Redmer, K J Ren, A Rivetti, V Rodin, M Rolo, G Rong, Ch Rosner, S N Ruan, N Salone, A Sarantsev, Y Schelhaas, K Schoenning, M Scodeggio, K Y Shan, W Shan, X Y Shan, J F Shangguan, L G Shao, M Shao, C P Shen, H F Shen, W H Shen, X Y Shen, B A Shi, H C Shi, J L Shi, J Y Shi, Q Q Shi, R S Shi, X Shi, J J Song, T Z Song, W M Song, Y J Song, Y X Song, S Sosio, S Spataro, F Stieler, Y J Su, G B Sun, G X Sun, H Sun, H K Sun, J F Sun, K Sun, L Sun, S S Sun, T Sun, W Y Sun, Y Sun, Y J Sun, Y Z Sun, Z T Sun, Y X Tan, C J Tang, G Y Tang, J Tang, Y A Tang, L Y Tao, Q T Tao, M Tat, J X Teng, V Thoren, W H Tian, W H Tian, Y Tian, Z F Tian, I Uman, S J Wang, B Wang, B L Wang, Bo Wang, C W Wang, D Y Wang, F Wang, H J Wang, H P Wang, J P Wang, K Wang, L L Wang, M Wang, Meng Wang, S Wang, S Wang, T Wang, T J Wang, W Wang, W Wang, W P Wang, X Wang, X F Wang, X J Wang, X L Wang, Y Wang, Y D Wang, Y F Wang, Y H Wang, Y N Wang, Y Q Wang, Yaqian Wang, Yi Wang, Z Wang, Z L Wang, Z Y Wang, Ziyi Wang, D Wei, D H Wei, F Weidner, S P Wen, C W Wenzel, U W Wiedner, G Wilkinson, M Wolke, L Wollenberg, C Wu, J F Wu, L H Wu, L J Wu, X Wu, X H Wu, Y Wu, Y J Wu, Z Wu, L Xia, X M Xian, T Xiang, D Xiao, G Y Xiao, H Xiao, S Y Xiao, Y L Xiao, Z J Xiao, C Xie, X H Xie, Y Xie, Y G Xie, Y H Xie, Z P Xie, T Y Xing, C F Xu, C J Xu, G F Xu, H Y Xu, Q J Xu, Q N Xu, W Xu, W L Xu, X P Xu, Y C Xu, Z P Xu, Z S Xu, F Yan, L Yan, W B Yan, W C Yan, X Q Yan, H J Yang, H L Yang, H X Yang, Tao Yang, Y Yang, Y F Yang, Y X Yang, Yifan Yang, Z W Yang, Z P Yao, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, G Yu, J S Yu, T Yu, X D Yu, C Z Yuan, L Yuan, S C Yuan, X Q Yuan, Y Yuan, Z Y Yuan, C X Yue, A A Zafar, F R Zeng, X Zeng, Y Zeng, Y J Zeng, X Y Zhai, Y C Zhai, Y H Zhan, A Q Zhang, B L Zhang, B X Zhang, D H Zhang, G Y Zhang, H Zhang, H H Zhang, H H Zhang, H Q Zhang, H Y Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J X Zhang, J Y Zhang, J Z Zhang, Jianyu Zhang, Jiawei Zhang, L M Zhang, L Q Zhang, Lei Zhang, P Zhang, Q Y Zhang, Shuihan Zhang, Shulei Zhang, X D Zhang, X M Zhang, X Y Zhang, Xuyan Zhang, Y Zhang, Y Zhang, Y T Zhang, Y H Zhang, Yan Zhang, Yao Zhang, Z H Zhang, Z L Zhang, Z Y Zhang, Z Y Zhang, G Zhao, J Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, S J Zhao, Y B Zhao, Y X Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, X Zhong, H Zhou, L P Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, Y Z Zhou, J Zhu, K Zhu, K J Zhu, L Zhu, L X Zhu, S H Zhu, S Q Zhu, T J Zhu, W J Zhu, Y C Zhu, Z A Zhu, J H Zou, J Zu
We report the measurement of the inclusive cross sections for e^{+}e^{-}→nOCH (where nOCH denotes non-open charm hadrons) with improved precision at center-of-mass (c.m.) energies from 3.645 to 3.871 GeV. We observe three resonances: R(3760), R(3780), and R(3810) with significances of 8.1σ, 13.7σ, and 8.8σ, respectively. The R(3810) state is observed for the first time, while the R(3760) and R(3780) states are observed for the first time in the nOCH cross sections. Two sets of resonance parameters describe the energy-dependent line shape of the cross sections well...
May 10, 2024: Physical Review Letters
#9
JOURNAL ARTICLE
Emelie Butler Forslund, Minh Tat Nhat Truong, Ruoli Wang, Åke Seiger, Elena M Gutierrez-Farewik
This is a protocol for comprehensive analysis of gait and affecting factors in individuals with incomplete paraplegia due to spinal cord injury (SCI). A SCI is a devastating event affecting both sensory and motor functions. Due to better care, the SCI population is changing, with a greater proportion retaining impaired ambulatory function. Optimizing ambulatory function after SCI remains challenging. To investigate factors influencing optimal ambulation, a multi-professional research project was grounded with expertise from clinical rehabilitation, neurophysiology, and biomechanical engineering from Karolinska Institutet, the Spinalis Unit at Aleris Rehab Station (Sweden's largest center for specialized neurorehabilitation), and the Promobilia MoveAbility Lab at KTH Royal Institute of Technology...
May 4, 2024: Methods and Protocols
#10
JOURNAL ARTICLE
Han Wu, Jinfa Ye, Minjie Zhang, Lingyu Zhang, Sijie Lin, Qingjian Li, Yanbo Liu, Yun Han, Caihong Huang, Yiming Wu, Yuhang Cheng, Shundong Cai, Lang Ke, Gang Liu, Wei Li, Chengchao Chu
Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcomings or evoke some adverse effects. Recently, SU6668, an inhibitor targeting angiogenic tyrosine kinases, has demonstrated growth inhibition of neovascularization. But the hydrophobicity and low ocular bioavailability limit its application in cornea. Hereby, we proposed the preparation of SU6668 pure nanoparticles (NanoSU6668; size ~135 nm) using a super-stable pure-nanomedicine formulation technology (SPFT), which possessed uniform particle size and excellent aqueous dispersion at 1 mg/mL...
May 27, 2024: Journal of Nanobiotechnology
#11
JOURNAL ARTICLE
Jisan Hong, Dahye Sim, Byung-Heon Lee, Vijaya Sarangthem, Rang-Woon Park
BACKGROUND: The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment. Nevertheless, its effectiveness is often impeded by challenges, including a short half-life, propensity for off-target accumulation, susceptibility to inactivation by blood-based enzymes, concerns regarding patient safety, and the substantial cost associated with scaling up. As a means of overcoming these barriers, we propose the development of miRNA-loaded Tat-A86 nanoparticles by virtue of Tat-A86's ability to shield the loaded agent from external environmental factors, reducing degradation and inactivation, while enhancing circulation time and targeted accumulation...
May 27, 2024: Journal of Nanobiotechnology
#12
JOURNAL ARTICLE
Pauline Depierre, Vanessa Ginet, Anita C Truttmann, Julien Puyal
Macroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery of autosis, a Na+ /K+ -ATPase (ATP1)-dependent type of autophagic cell death with specific morphological and biochemical features, has strongly contributed to the acceptance of a pro-death role of autophagy. However, the occurrence and relevance of autosis in neurons has never been clearly investigated, whereas we previously provided evidence that autophagy mechanisms could be involved in neuronal death in different in vitro and in vivo rodent models of hypoxia-ischemia (HI) and that morphological features of autosis were observed in dying neurons following rat perinatal cerebral HI...
May 25, 2024: Cell Death & Disease
#13
JOURNAL ARTICLE
Nakwon Kwak, Sangyeop Lee, Suyeoun Kim, Eunbee Song, Jae-Joon Yim, Tae Sun Shim, Doosoo Jeon, Byung Woo Jhun, Kwang-Hyuk Seok, Saerom Kim, Sunghoon Kwon, Jeongha Mok
Background/Objectives: This study explores the impact of QMAC-DST, a rapid, fully automated phenotypic drug susceptibility test (pDST), on the treatment of tuberculosis (TB) patients. Methods: This pre-post comparative study, respectively, included pulmonary TB patients who began TB treatment between 1 December 2020 and 31 October 2021 (pre-period; pDST using the Löwenstein-Jensen (LJ) DST (M-kit DST)) and between 1 November 2021 and 30 September 2022 (post-period; pDST using the QMAC-DST) in five university-affiliated tertiary care hospitals in South Korea...
May 16, 2024: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Wenwei Zhang, Hui Xia, Xiaonan Li, Yuanyuan Li, Shiqiang Li, Guoqiang Liu
OBJECTIVE: Thermoacoustic tomography (TAT) is a promising imaging technique used for early cancer diagnosis, tumor therapy, animal study and brain imaging. Although it's widely known that the TAT frequency response depends on the pulse width of the source and the size of the object, a thorough comprehension of the quantitative frequency modulation in TAT and the mechanism governing the shift in the thermoacoustic pressure spectrum towards lower frequencies with respect to the excitation source is still lacking...
May 24, 2024: Physics in Medicine and Biology
#15
JOURNAL ARTICLE
C J Okeke, E A Jeje, R W Ojewola, M A Ogunjimi, U U Ogbobe, A O Obi, R N Babalola
INTRODUCTION: Prostate cancer is still the leading male cancer and the leading cause of cancer deaths in Nigeria, and other low- and middle-income countries (LMIC) in Sub-Saharan Africa. Early diagnosis is essential to ensuring prompt treatment and reducing morbidity and mortality. Reducing the waiting times for diagnosis and treatment is therefore important. AIMS AND OBJECTIVES: To study prostate cancer management waiting times, to serve as a baseline in improving the quality of cancer care in the Nigerian populace...
March 29, 2024: West African Journal of Medicine
#16
MULTICENTER STUDY
Saadettin Kilickap, Akin Ozturk, Nuri Karadurmus, Taner Korkmaz, Perran Fulden Yumuk, Irfan Cicin, Semra Paydas, Ebru Cilbir, Teoman Sakalar, Mukremin Uysal, Havva Yesil Cinkir, Necdet Uskent, Necla Demir, Abdullah Sakin, Oldac Uras Dursun, Birkan Aver, Nazim Serdar Turhal, Serkan Keskin, Deniz Tural, Yesim Eralp, Fatma Bugdayci Basal, Hatime Arzu Yasar, Mehmet Ali Nahit Sendur, Umut Demirci, Erdem Cubukcu, Mustafa Karaagac, Burcu Cakar, Ali Murat Tatli, Tarkan Yetisyigit, Semiha Urvay, Pinar Gursoy, Basak Oyan, Zeynep Hande Turna, Abdurrahman Isikdogan, Omer Fatih Olmez, Ozan Yazici, Devrim Cabuk, Mehmet Metin Seker, Olcun Umit Unal, Nezih Meydan, Sadi Kerem Okutur, Didem Tunali, Mustafa Erman
To evaluate radiological and clinical features in metastatic anaplastic lymphoma kinase+ non-small cell lung cancer patients and crizotinib efficacy in different lines. This national, non-interventional, multicenter, retrospective archive screening study evaluated demographic, clinical, and radiological imaging features, and treatment approaches in patients treated between 2013-2017. Totally 367 patients (54.8% males, median age at diagnosis 54 years) were included. Of them, 45.4% were smokers, and 8.7% had a family history of lung cancer...
May 24, 2024: Medicine (Baltimore)
#17
JOURNAL ARTICLE
Monty Santarossa, Tebbo Tassilo Beyer, Amelie Bernadette Antonia Scharf, Ayse Tatli, Claus von der Burchard, Jakob Nazarenus, Johann Baptist Roider, Reinhard Koch
Hyperfluorescence (HF) and reduced autofluorescence (RA) are important biomarkers in fundus autofluorescence images (FAF) for the assessment of health of the retinal pigment epithelium (RPE), an important indicator of disease progression in geographic atrophy (GA) or central serous chorioretinopathy (CSCR). Autofluorescence images have been annotated by human raters, but distinguishing biomarkers (whether signals are increased or decreased) from the normal background proves challenging, with borders being particularly open to interpretation...
May 9, 2024: Journal of Imaging
#18
JOURNAL ARTICLE
Tat Fong Ng, Jenna Y Cho, John L Zhao, John R Gardiner, Eric S Wang, Elman Leung, Ziqian Xu, Samantha L Fineman, Melinda Lituchy, Amy C Lo, Andrew W Taylor
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death. Therefore, we investigated the effects of a therapeutic application of the melanocortin alpha-melanocyte-stimulating hormone (α-MSH) on an ischemia and reperfusion (I/R) model of retinal degenerative disease. Eyes were subjected to an I/R procedure and were treated with α-MSH. Retinal sections were histopathologically scored...
April 27, 2024: Biomolecules
#19
Cassie Yang, Alagan Gnanam, John Chen Li Tat, Ou Yang Youheng
INTRODUCTION: Multiple spinal epidual abscesses with multifocal systemic abscess and multiple joint septic arthritis present with a large infective burden resulting in sepsis, systemic inflammatory dysregulation, and multi-organ failure. This requires pre-operative resuscitation and surgery of greater complexity, longer operative duration, and blood loss, creating challenges to surgical management. CASE REPORT: A 69-year-old Chinese female presented with multilevel discrete spinal epidural abscesses along the cervical, thoracic, and lumbar spine, alongside concomitant multifocal systemic abscesses and multiple small joint septic arthritis...
May 2024: Journal of Orthopaedic Case Reports
#20
JOURNAL ARTICLE
Tong Kang, Jiamin Chen, Weijun Wan, Jinshu Pang, Rong Wen, Xiumei Bai, Lipeng Li, Yunjing Pan, Yun He, Hong Yang
TAT, a widely used treatment for HCC, can exacerbate the progression of residual HCC. The present study investigated the mechanism of action of PLK1 following ITA of HCC. The PLK1 levels in HCC were determined using qRT-PCR from clinical patient samples, IHC from tissue microarray, and data from globally high-throughput data and microarrays. The PLK1 levels and their effect on the biological phenotype of heat-stress HCC cells were evaluated through in vitro experiments. We detected PLK1 abnormal expression in HCC models of nude mice subjected to ITA...
May 23, 2024: Molecular Biotechnology
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