S Rehan Ahmad, Md Zeyaullah, Abdullah M AlShahrani, Adam Dawria, Haroon Ali, Ali Mohieldin, Abdelrhman Ag Altijani, Ufaq Razi, Munzila Mehdi, Sabika Akram, Ejaz Rizvi Hussain
Innate lymphocytes, including microglial cells, astrocytes, and oligodendrocytes, play a crucial role in initiating neuroinflammatory reactions inside the central nervous system (CNS). The prime focus of this paper is on the involvement and interplay of neurons and glial cells in neurological disorders such as Alzheimer's Disease (AD), Autism Spectrum Disorder (ASD), epilepsy, and multiple sclerosis (MS). In this review, we explore the specific contributions of microglia and astrocytes and analyzes multiple pathways implicated in neuroinflammation and disturbances in excitatory and inhibitory processes...
April 8, 2024: Frontiers in Bioscience (Landmark Edition)