keyword
https://read.qxmd.com/read/38700812/the-diagnosis-and-prevalence-of-hypoprolactinemia-in-patients-with-panhypopituitarism-and-the-effects-on-depression-and-sexual-functions
#1
JOURNAL ARTICLE
Ilknur Uzun, Zuleyha Karaca, Aysa Hacioğlu, Kursad Unluhizarci, Fahrettin Kelestimur
PURPOSE: We aimed to investigate the prevalence and the diagnostic criteria of hypoprolactinemia in patients with panhypopituitarism and the effects of hypoprolactinemia on depression and sexual functions. MATERIALS AND METHODS: Forty-eight patients with panhypopituitarism and 20 healthy volunteers were included. Basal hormone levels were measured and a TRH stimulation test was performed. For the evaluation of sexual functions, questionnaries of Female Sexual Functional Index (FSFI) for females and International Erectile Functional Index for males were performed to the subjects...
May 3, 2024: Pituitary
https://read.qxmd.com/read/38676521/sars-cov-2-infection-a-new-risk-factor-for-pituitary-apoplexy
#2
JOURNAL ARTICLE
Alberto Ragni, Giulia Bendotti, Emilia Biamonte, Beatrice Cavigiolo, Enrico Gabellieri, Paola Leporati, Edoardo Luigi Maria Mollero, Marco Gallo
BACKGROUND: Pituitary apoplexy (PA) can arise from haemorrhage or ischaemia of pituitary tissue and is characterized by abrupt onset of headache, visual impairment and hypopituitarism. COVID-19 may be associated with various degrees of vascular complications and, recently, its relationship with PA has been suggested. Cases Presentation Case 1: A 64-year-old male with type 2 diabetes, hypertension and coronary heart disease was admitted to the ER, after several days of asymptomatic COVID-19 infection, with symptoms of PA of a known non-functioning pituitary macroadenoma...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38669701/endoscopic-endonasal-pituitary-sacrifice-for-select-tumors-with-retrochiasmatic-and-or-retrosellar-extension-surgical-anatomy-operative-technique-and-case-series
#3
JOURNAL ARTICLE
Jonathan Rychen, Karam Asmaro, Felipe Constanzo, Vladimir A Ljubimov, Min Ho Lee, Mariano Rinaldi, Limin Xiao, Enrico Gambatesa, Yuanzhi Xu, Christine K Lee, Vera Vigo, Juan C Fernandez-Miranda
OBJECTIVE: Tumors located in the retrochiasmatic region with extension to the third ventricle might be difficult to access when the pituitary-chiasmatic corridor is narrow. Similarly, tumor extension into the interpeduncular and retrosellar space poses a major surgical challenge. Pituitary transposition techniques have been developed to gain additional access. However, when preoperative pituitary function is already impaired or the risk of postoperative panhypopituitarism (PH) is considered to be particularly high, removal of the pituitary gland (PG) might be the preferred option to increase the working corridor...
April 26, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38660086/panhypopituitarism-caused-by-a-suprasellar-germinoma-a-case-report
#4
Jelena Roganovic, Lea Saric, Silvije Segulja, Ana Dordevic, Mia Radosevic
BACKGROUND: Suprasellar germinomas are rare intracranial tumors frequently associated with permanent endocrine disorders. We present the clinical picture, treatment, and complications of suprasellar germinoma at pediatric age which, besides being life-threatening, has lifelong endocrinological consequences. CASE SUMMARY: A 12-year-old female patient was presented having had intensive headaches for three weeks and visual disturbances for six months. An ophthalmological examination revealed bilateral papilledema and a marked loss of vision...
April 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38658327/-a-case-of-primary-central-nervous-system-lymphoma-of-the-sellar-region-presented-with-panhypopituitarism
#5
JOURNAL ARTICLE
Ayaka Seki, Fumiaki Henmi, Shinji Ito, Hironori Uruga, Kei Arisawa, Yoshikazu Uesaka
The patient is a 41-year-old woman. She presented with vomiting and lightheadedness, and blood tests showed a generalized decrease in pituitary hormones and hyperprolactinemia. A head MRI showed increased signal intensity lesions on FLAIR image in the pituitary stalk, corpus callosum, periventricular area of the fourth ventricle, and superior cerebellar peduncle. The lesions were homogeneously enhanced, and a brain biopsy confirmed the diagnosis of primary diffuse large B-cell lymphoma of the central nervous system, and chemotherapy was started...
April 25, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38633287/first-local-experience-of-intra-cavitary-yttrium-90-citrate-colloid-irradiation-via-ommaya-reservoir-for-refractory-cystic-craniopharyngioma-a-case-report
#6
Nadiah Abd Razak, Pung Choon Ping, Kamalia Kamarulzaman, Siti Zarina Amir Hassan
Craniopharyngioma is uncommon benign intracranial tumour that can be cured by surgical resection followed by conventional radiotherapy. However, its anatomical localisation makes the treatment hazardous or impossible. This case report aims to discuss the first local experience of using beta-emitting Yttrium-90 radioisotope in treating a patient with refractory cystic craniopharyngioma. A 43-year-old male who has underlying refractory cystic craniopharyngioma complicated with visual impairment and panhypopituitarism was referred to our nuclear medicine department for intra-cavitary irradiation therapy...
May 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38524058/heritable-pulmonary-arterial-hypertension-in-a-patient-with-empty-sella-syndrome-a-case-report
#7
Bader Alghamdi, Shahad Aljuhani, Ghaday Alansari, Nouf M BinHumaid, Abdulkareem Alkahtani
Pulmonary arterial hypertension (PAH) is a progressive disease with multiple contributing factors. Genetics, epigenetics, hormonal, and immune factors all contribute to the development and progression of the disease. A number of endocrine disorders and metabolic syndromes are being studied for their potential role in the development of PAH. We report to you a case of a 32-year-old female with a rare presentation of a non-BMPR2 mutation heritable PAH complicated with empty sella syndrome and panhypopituitarism...
February 2024: Curēus
https://read.qxmd.com/read/38462513/hypopituitarism-due-to-cns-aspergillus-infection
#8
JOURNAL ARTICLE
Shogo Funakoshi, Mitsuru Nishiyama, Masahiro Komori, Masamitsu Hyodo, Yu Kawanishi, Tetsuya Ueba, Shimpei Fujimoto, Yoshio Terada
A 59-year-old man was admitted to our hospital with hyponatremia. An endocrine examination indicated panhypopituitarism, and magnetic resonance imaging revealed a mass-like lesion in the pituitary gland. Sinus endoscopy revealed a fungal mass in the sphenoid sinus, and the patient was diagnosed with hypopituitarism due to aspergillosis of the central nervous system (CNS). The patient's hyponatremia resolved with hydrocortisone replacement. Although the right internal carotid artery was eventually occluded, antifungal medications were administered for the aspergillosis, and the patient's general condition improved...
March 11, 2024: Internal Medicine
https://read.qxmd.com/read/38390278/a-case-report-of-a-child-with-pulmonary-hypertension-associated-with-sars-cov-2-infection
#9
Kentaro Okunushi, Hironobu Kobayashi, Yuri Yoh, Masaya Kunimatsu, Tadashi Shiohama, Tomozumi Takatani, Hiromichi Hamada
We encountered a pediatric case of pulmonary hypertension triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 14-year-old girl was brought to the emergency department of our hospital with fever, respiratory distress, and impaired consciousness. She tested positive for SARS-CoV-2 upon a polymerase chain reaction examination and had prolonged hypoxemia without pneumonia. An echocardiography revealed elevated right ventricular pressure. She was diagnosed with pilocytic astrocytoma at the age of 10 years and underwent a resection of a pituitary tumor...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38381107/-panhypopituitarism-diabetes-insipidus-and-bone-pain-is-there-a-systemic-disease-behind-it
#10
JOURNAL ARTICLE
Martina Bertschinger, Lisa Sze, Irene Bosma, Corina Dommann-Scherrer, Jeroen Goede
A 27-year-old man presented due to unilateral leg pain. He had a history of diabetes insipidus and panhypopituitarism. Laboratory analysis revealed hormonal undersupply. MRI showed a large contrast medium-absorbing mass in the pituitary gland extending into the hypothalamus. FDG-PET/CT examination revealed a hypermetabolic soft tissue lesion around the left femoral shaft. After biopsy of the lesion, a diagnosis of multisystemic Langerhans cell histiocytosis was made.
January 2024: Praxis
https://read.qxmd.com/read/38355813/development-and-validation-of-a-prediction-model-for-consistency-of-pituitary-adenoma-the-pitcon-score
#11
JOURNAL ARTICLE
Alberto Acitores Cancela, Víctor Rodríguez Berrocal, Hector Pian Arias, Juan José Díez Gómez, Pedro Iglesias Lozano
PURPOSE: Pituitary adenomas (PAs) usually have a soft consistency, facilitating gross total resection. However, 5-13% of PAs with fibrous consistency are challenging to remove entirely and are accompanied by greater morbimortality. This study aims to identify the clinical and radiological characteristics that correlate with PA fibrous consistency preoperatively. A simple scoring system has been proposed to predict incidence of fibrous PAs. MATERIALS AND METHODS: Consecutive interventions (226) were analyzed, all performed through an endoscopic endonasal transsphenoidal approach...
February 15, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38344342/delayed-sheehan-s-syndrome-diagnosed-during-the-evaluation-of-secondary-infertility-a-case-report
#12
Surbhi Saxena, Vishesh Verma, Samir Samadarshi, Thinley Dorji, Jayaraman Muthukrishnan
Sheehan's syndrome may present with postpartum lactation failure and amenorrhea or with features of isolated hypopituitarism to panhypopituitarism. A high index of suspicion is required in a relevant clinical setting of postpartum hemorrhage.
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38303770/pituitary-abscess-causing-panhypopituitarism-in-a-patient-with-neurobrucellosis-case-report
#13
Gustavo De la Peña-Sosa, Abraham I Cabello-Hernández, Roxana P Gómez-Ruíz, Miguel A Gómez-Sámano, Francisco J Gómez-Pérez
BACKGROUND/OBJECTIVE: Pituitary abscess is an uncommon life-threatening disease that could lead to panhypopituitarism. It is important to suspect its prevalence in regions with endemic infectious diseases. CASE REPORT: A 55-year-old man, a farmer, with a background of consumption of unpasteurized dairy products, presented with headache, impaired consciousness, and fever that started in February 2023. Initial test results were consistent with neuroinfection. Brain MRI showed ventriculitis; the pituitary gland was heterogeneous with the presence of an 8 × 8 mm abscess...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38281757/secondary-vs-primary-pituitary-xanthogranulomas-which-yellow-is-more-mellow
#14
JOURNAL ARTICLE
Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marko Stojanovic, Sasa Ilic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Toplica Milojevic, Mihailo Milicevic, Marija Jovanovic, Milica Medic Stojanoska, Bojana Carić, Nevena Radic, Sanja Medenica, Emilija Manojlovic Gacic, Milan Petakov
Pituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -"pure" XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, we identified 16 (2...
January 27, 2024: Endocrine Journal
https://read.qxmd.com/read/38218060/hypothalamic-pituitary-dysfunction-after-nasopharyngeal-carcinoma-irradiation
#15
JOURNAL ARTICLE
Nadia Bouzid, Amal Chamsi, Ines Barka, Sarra Sghaier, Sabrine Tbessi, Koussay Elleuch, Sameh Tebra
PURPOSE: Radiotherapy (RT) is the corner stone of nasopharyngeal carcinoma (NPC) treatment but it exposes to late effects especially hypothalamic pituitary deficiency (HPD). In this article,we aimed to assess the impact of RT on pituitary function in NPC survivors. METHODS: We included 55 patients treated in the radiation oncology department, of Farhat Hached Hospital in Sousse, Tunisia. RESULTS: All patients received facio-cervical RT with a mean dose of 73...
December 22, 2023: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38156081/hypopituitarism-due-to-a-large-osteoclastoma-arising-from-the-sphenoid-bone-invading-the-pituitary-fossa-in-a-patient-with-parathyroid-carcinoma
#16
Leonardo Bandeira, Lucian Batista de Oliveira, Maria Vitória Silva de Lima, Daniella Rêgo, Luiz Griz, Francisco Bandeira
BACKGROUND: Parathyroid carcinoma accounts for <1% of cases of primary hyperparathyroidism (PHPT). This rare condition may present with severe hypercalcemia and bone complications such as osteoclastomas and pathologic fractures. Here, we present a rare condition of panhypopituitarism resulting from an osteoclastoma in the sphenoid bone that invaded the pituitary fossa due to parathyroid carcinoma. Case Report . A 47-year-old woman previously diagnosed with PHPT underwent a parathyroidectomy 6 years earlier, with histological examination indicating a parathyroid adenoma...
2023: Case Reports in Endocrinology
https://read.qxmd.com/read/38135897/a-novel-ttc26-variant-in-a-patient-with-hexadactyly-pituitary-stalk-interruption-hepatopathy-nephropathy-and-bilateral-lip-palate-cleft-a-case-report-and-expansion-of-the-phenotype
#17
Dzhoy Papingi, Tatjana Bierhals, Alexander E Volk, Michael Kutsche, Kevin Paul, Theresia Herget
Biallelic pathogenic variants in the TTC26 gene are known to cause BRENS (biliary, renal, neurological, skeletal) syndrome, an ultra-rare autosomal recessive condition with only few patients published to date. BRENS syndrome is characterized by hexadactyly, severe neonatal cholestasis, and involvement of the brain, heart, and kidney, however the full phenotypic and genotypic spectrum is unknown. Here, we report on a previously undescribed homozygous intronic TTC26 variant (c.1006-5 T > C) in a patient showing some of the known TTC26-associated features like hexadactyly, hypopituitarism, hepatopathy, nephropathy, and congenital heart defect...
December 22, 2023: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38131878/a-case-of-igg4-related-hypophysitis-maintained-remission-of-diabetes-insipidus-for-over-3-months-after-completion-of-steroid-treatment
#18
JOURNAL ARTICLE
Motohiro Kubori, Megumi Fujimoto, Yukiyoshi Okauchi, Kanae Matsuno, Eri Yamabayashi, Ryuki Sakamoto, Shinya Inada, Hiromi Iwahashi
SUMMARY: IgG4-related disease is a multiorgan disorder in which nodules and hypertrophic lesions are observed simultaneously, or separately, in areas including the pancreas, liver, lungs, salivary glands, thyroid glands, and pituitary glands. IgG4-related hypophysis is one of several IgG4-related diseases and is characterized by pituitary gland and pituitary stalk thickening, various degrees of hypopituitarism, and increased serum IgG4 levels. Steroid therapy is effective for patients with IgG4-related hypophysis, but the reported effectiveness of steroid therapy for restoring pituitary function differs between studies...
October 1, 2023: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38125262/rare-case-of-a-clival-chondroma-resulting-in-panhypopituitarism
#19
Ekrem Yetiskul, Yisroel Y Grabie, Amira Hassan, Fatema Arafa, Salman Khan
Chondromas are rare benign tumors composed of hyaline cartilage that can arise in various locations in the body. Their occurrence in the clivus, leading to panhypopituitarism, is exceptionally rare. This case report describes a 93-year-old female with a known clival chondroma who presented with altered mental status, presumed to be secondary to toxic metabolic encephalopathy due to an infectious cause. Further diagnostic evaluation revealed pituitary hormone levels below the normal range. This case report aims to highlight a unique case of panhypopituitarism attributed to a chondroma in the clivus with tumor extension to the sellar region, emphasizing the diagnostic challenges and treatment options for this unusual pathology...
November 2023: Curēus
https://read.qxmd.com/read/38098557/pituitary-macroadenoma-with-panhypopituitarism-masquerading-as-schizophrenia-a-diagnostic-dilemma-managed-conservatively
#20
Sagun Ghimire, Suman Simkhada, Saroj Sah, Amit Subedi
INTRODUCTION AND IMPORTANCE: Secretory pituitary macroadenoma also known as prolactinoma are benign neoplasm comprising very minimal cases of intracranial masses. Among the various presentation suggestive of panhypopituitarism, psychosis, and features of schizophrenia is very rarely seen. In the majority of cases, neurosurgical intervention for the excision of tumor is considered a standard treatment modality but conservative management with dopamine agonist and steroids have also been shown to provide an optimal level of care also improving the quality of level of patient...
December 2023: Annals of Medicine and Surgery
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