Li Luo, Ronglai Shen, Arshi Arora, Irene Orlow, Klaus J Busam, Cecilia Lezcano, Tim K Lee, Eva Hernando, Ivan Gorlov, Christopher Amos, Marc S Ernstoff, Venkatraman E Seshan, Anne E Cust, James Wilmott, Richard A Scolyer, Graham Mann, Eduardo Nagore, Pauline Funchain, Jennifer Ko, Peter Ngo, Sharon N Edmiston, Kathleen Conway, Paul B Googe, David Ollila, Jeffrey E Lee, Shenying Fang, Judy R Rees, Cheryl L Thompson, Meg Gerstenblith, Marcus Bosenberg, Bonnie Gould Rothberg, Iman Osman, Yvonne Saenger, Adam Z Reynolds, Matthew Schwartz, Tawny Boyce, Sheri Holmen, Elise Brunsgaard, Paul Bogner, Pei Fen Kuan, Charles Wiggins, Nancy E Thomas, Colin B Begg, Marianne Berwick
It is unclear why some melanomas aggressively metastasize while others remain indolent. Available studies employing multi-omic profiling of melanomas are based on large primary or metastatic tumors. We examine the genomic landscape of early-stage melanomas diagnosed prior to the modern era of immunological treatments. Untreated cases with Stage II/III cutaneous melanoma were identified from institutions throughout the United States, Australia and Spain. FFPE tumor sections were profiled for mutation, methylation and microRNAs...
July 25, 2022: Pigment Cell & Melanoma Research