Anna Maria Pavone, Viviana Benfante, Paolo Giaccone, Alessandro Stefano, Filippo Torrisi, Vincenzo Russo, Davide Serafini, Selene Richiusa, Marco Pometti, Fabrizio Scopelliti, Massimo Ippolito, Antonino Giulio Giannone, Daniela Cabibi, Mattia Asti, Elisa Vettorato, Luca Morselli, Mario Merone, Marcello Lunardon, Alberto Andrighetto, Antonino Tuttolomondo, Francesco Paolo Cammarata, Marco Verona, Giovanni Marzaro, Francesca Mastrotto, Rosalba Parenti, Giorgio Russo, Albert Comelli
The aim of the present study consists of the evaluation of the biodistribution of a novel 68 Ga-labeled radiopharmaceutical, [68 Ga]Ga-NODAGA-Z360, injected into Balb/c nude mice through histopathological analysis on bioptic samples and radiomics analysis of positron emission tomography/computed tomography (PET/CT) images. The 68 Ga-labeled radiopharmaceutical was designed to specifically bind to the cholecystokinin receptor (CCK2R). This receptor, naturally present in healthy tissues such as the stomach, is a biomarker for numerous tumors when overexpressed...
March 20, 2024: Life