Rakhee Banerjee, Rachel C Hohe, Shijie Cao, Bryan M Jung, Anthony J Horak, Iyappan Ramachandiran, William J Massey, Venkateshwari Varadharajan, Natalie I Zajczenko, Amy C Burrows, Sumita Dutta, Maryam Goudarzi, Kala Mahen, Abigail Carter, Robert N Helsley, Scott M Gordon, Richard E Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, J Mark Brown
INTRODUCTION: The Aster-C protein (encoded by the Gramd1c gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma membrane to the ER. Although there is a clear role for the closely-related Aster-B protein in cholesterol transport and downstream esterification in the adrenal gland, the specific role for Aster-C in cholesterol homeostasis is not well understood. Here, we have examined whole body cholesterol balance in mice globally lacking Aster-C under low or high dietary cholesterol conditions...
2024: Frontiers in Physiology