Rémy A Bonnin, Elodie Creton, Amandine Perrin, Delphine Girlich, Cecile Emeraud, Agnès B Jousset, Mathilde Duque, Aymeric Jacquemin, Katie Hopkins, Pierre Bogaerts, Youri Glupczynski, Niels Pfennigwerth, Marek Gniadkowski, Antoni P A Hendrickx, Kim van der Zwaluw, Petra Apfalter, Rainer Hartl, Vendula Studentova, Jaroslav Hrabak, Gerald Larrouy-Maumus, Eduardo P C Rocha, Thierry Naas, Laurent Dortet
BACKGROUND: Morganella spp are opportunistic pathogens involved in various infections. Intrinsic resistance to multiple antibiotics (including colistin) combined with the emergence of carbapenemase producers reduces the number of active antimicrobials. The aim of this study was to characterise genetic features related to the spread of carbapenem-resistant Morganella spp. METHODS: This comparative genomic study included extensively drug-resistant Morganella spp isolates collected between Jan 1, 2013, and March 1, 2021, by the French National Reference Center (NRC; n=68) and European antimicrobial resistance reference centres in seven European countries (n=104), as well as one isolate from Canada, two reference strains from the Pasteur Institute collection (Paris, France), and two colistin-susceptible isolates from Bicêtre Hospital (Kremlin-Bicêtre, France)...
April 24, 2024: The Lancet. Microbe