Adriano Bernini, Mojgan Masoodi, Daria Solari, John-Paul Miroz, Laurent Carteron, Nicolas Christinat, Paola Morelli, Maurice Beaumont, Samia Abed-Maillard, Mickael Hartweg, Fabien Foltzer, Philippe Eckert, Bernard Cuenoud, Mauro Oddo
Adaptive metabolic response to injury includes the utilization of alternative energy substrates - such as ketone bodies (KB) - to protect the brain against further damage. Here, we examined cerebral ketone metabolism in patients with traumatic brain injury (TBI; n = 34 subjects) monitored with cerebral microdialysis to measure total brain interstitial tissue KB levels (acetoacetate and β-hydroxybutyrate). Nutrition - from fasting vs. stable nutrition state - was associated with a significant decrease of brain KB (34...
January 2020: Journal of Cerebral Blood Flow and Metabolism