Xi Wang, Zhijian Cheng, Wenjiao Tai, Mingjun Shi, Maryam Ayazi, Yang Liu, Li Sun, Caiyong Yu, Zhongmin Fan, Bin Guo, Xijing He, Dongming Sun, Wise Young, Yi Ren
Spinal cord injury (SCI) triggers a complex cascade of events, including myelin loss, neuronal damage, neuroinflammation, and the accumulation of damaged cells and debris at the injury site. Infiltrating bone marrow derived macrophages (BMDMϕ) migrate to the epicenter of the SCI lesion, where they engulf cell debris including abundant myelin debris to become pro-inflammatory foamy macrophages (foamy Mϕ), participate neuroinflammation, and facilitate the progression of SCI. This study aimed to elucidate the cellular and molecular mechanisms underlying the functional changes in foamy Mϕ and their potential implications for SCI...
April 16, 2024: Brain, Behavior, and Immunity