Mathias V Schmidt, Jan-Philip Schülke, Claudia Liebl, Michael Stiess, Charilaos Avrabos, Jörg Bock, Gabriela M Wochnik, Heather A Davies, Nicole Zimmermann, Sebastian H Scharf, Dietrich Trümbach, Wolfgang Wurst, Walter Zieglgänsberger, Christoph Turck, Florian Holsboer, Michael G Stewart, Frank Bradke, Matthias Eder, Marianne B Müller, Theo Rein
Stress has been identified as a major causal factor for many mental disorders. However, our knowledge about the chain of molecular and cellular events translating stress experience into altered behavior is still rather scant. Here, we have characterized a murine ortholog of the putative tumor suppressor gene DRR1 as a unique stress-induced protein in brain. It binds to actin, promotes bundling and stabilization of actin filaments, and impacts on actin-dependent neurite outgrowth. Endogenous DRR1 localizes to some, but not all, synapses, with preference for the presynaptic region...
October 11, 2011: Proceedings of the National Academy of Sciences of the United States of America