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https://read.qxmd.com/read/30879276/inhibition-of-er-stress-by-2-aminopurine-treatment-modulates-cardiomyopathy-in-a-murine-chronic-chagas-disease-model
#1
Janeesh Plakkal Ayyappan, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F Nagajyothi
Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice...
March 13, 2019: Biomolecules & Therapeutics
https://read.qxmd.com/read/30879148/clinical-assessment-of-the-gnas-mutation-status-in-patients-with-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#2
REVIEW
Takao Ohtsuka, Takahiro Tomosugi, Ryuichiro Kimura, So Nakamura, Yoshihiro Miyasaka, Kohei Nakata, Yasuhisa Mori, Makiko Morita, Nobuhiro Torata, Koji Shindo, Kenoki Ohuchida, Masafumi Nakamura
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by cystic dilation of the pancreatic duct, caused by mucin hypersecretion, with slow progression via the adenoma-carcinoma sequence mechanism. Mutation of GNAS at codon 201 is found exclusively in IPMNs, occurring at a rate of 41-75%. Recent advances in molecular biological techniques have demonstrated that GNAS mutation might play a role in the transformation of IPMNs after the appearance of neoplastic cells, rather than in the tumorigenesis of IPMNs...
March 16, 2019: Surgery Today
https://read.qxmd.com/read/30879101/urethral-diverticulum-in-pregnancy-a-case-report
#3
Frida M Carswell
INTRODUCTION AND HYPOTHESIS: Urethral diverticulum in pregnancy is a rare finding and difficult to diagnose. The classical triad of dysuria, dyspareunia and dribbling of urine is found in a minority of women. METHODS: A young woman presented during the first trimester of pregnancy with vaginal and suprapubic pain as well as voiding difficulty. Ultrasound demonstrated a 2-cm hypoechoic lesion to the left of the urethra. She went on to have a cystoscopy that demonstrated a diverticulum...
March 16, 2019: International Urogynecology Journal
https://read.qxmd.com/read/30879001/prenatal-diagnosis-of-enterolithiasis-in-20-cases
#4
Michael R Mallmann, Heiko Reutter, Ingo Gottschalk, Annegret Geipel, Christoph Berg, Ulrich Gembruch
BACKGROUND: Enterolithiasis is a sonographic sign defined by hyperechogenic foci within the - often distended - fetal bowel. OBJECTIVES: We report on a series of 20 cases with enterolithiasis diagnosed prenatally and illustrate the spectrum of associated malformations. METHOD: This was a retrospective study involving 20 fetuses with enterolithiasis at two large tertiary referral centers in Germany over a 17-year period (2000-2017). RESULTS: Median diagnosis was made with ultrasound at 18+2 weeks of gestation (IQR25,75: 14+5, 26+5)...
March 15, 2019: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/30878998/a-systematic-ultrasound-evaluation-of-the-diameter-of-deep-veins-in-the-newborn-results-and-implications-for-clinical-practice
#5
Giovanni Barone, Vito D'Andrea, Giovanni Vento, Mauro Pittiruti
BACKGROUND: In adults and children, current guidelines recommend measuring the diameter of the vein before the insertion of central catheters, in order to match vein diameter with catheter caliber and thus reduce the risk of venous thrombosis. In the neonatal intensive care unit, central catheters are often used but the vein diameter is usually not considered. METHOD: We assessed the diameter of the most relevant deep veins in 100 newborns, using a strict protocol of ultrasound evaluation...
March 15, 2019: Neonatology
https://read.qxmd.com/read/30878995/adenomyosis-genetics-of-estrogen-metabolism
#6
Natalia Artymuk, Olga Zotova, Lyudmila Gulyaeva
Background To analyze the allelic variants of genes of enzymes involved in estrogen metabolism: CYP1A1, CYP1A2, CYP19 and SULT1A1 using polymerase chain reaction-restriction fragment length polymorphism-restriction fragment length polymorphism (PCR-RFLP) analysis of women with histologically confirmed adenomyosis and women without proliferative diseases of pelvic organs was performed. We studied the following polymorphisms: CYP1A1 M1, T264 → C transition in the 3'-noncoding region; CYP1A2*1F, C734 → A transversion in CYP1A2 gene; C → T transition (Arg264Cys) in exon 7 of CYP19; SULT1A1*2, G638 → A transition (Arg213His) in the SULT1A1 gene...
March 15, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30878974/synovial-cellular-and-molecular-signatures-stratify-clinical-response-to-csdmard-therapy-and-predict-radiographic-progression-in-early-rheumatoid-arthritis-patients
#7
Frances Humby, Myles Lewis, Nandhini Ramamoorthi, Jason A Hackney, Michael R Barnes, Michele Bombardieri, A Francesca Setiadi, Stephen Kelly, Fabiola Bene, Maria DiCicco, Sudeh Riahi, Vidalba Rocher, Nora Ng, Ilias Lazarou, Rebecca Hands, Désirée van der Heijde, Robert B M Landewé, Annette van der Helm-van Mil, Alberto Cauli, Iain McInnes, Christopher Dominic Buckley, Ernest H Choy, Peter C Taylor, Michael J Townsend, Costantino Pitzalis
OBJECTIVES: To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally. METHODS: 144 consecutive treatment-naïve early RA patients (<12 months symptoms duration) underwent ultrasound-guided synovial biopsy before and 6 months after disease-modifying antirheumatic drug (DMARD) initiation...
March 16, 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30878969/secondary-thyroid-malignancy-from-metastatic-colon-lymphoma
#8
Cristian Marco-Alacid, Mario López-Merseguer, Carlos Sánchez-Juan
Primary thyroid malignancy is more frequent than secondary. This case report describes a colon lymphoma with unique thyroid metastasis. When a thyroid lesion appears in an extension study such as Positron emission tomography-computed tomography marked with 18F-2-fluoro-2-deoxy-D-glucose, it is recommended to perform an ultrasound. The correct study with ultrasound and cytology obtained through fine needle aspiration on thyroid lesion allowed to refine the diagnosis and provide the correct treatment.
March 16, 2019: BMJ Case Reports
https://read.qxmd.com/read/30878896/comparison-of-placenta-accreta-spectrum-disorders-diagnosed-in-intrapartum-and-antepartum-period-a-three-year-experience-in-a-tertiary-referral-unit-of-india
#9
Pratima Mittal, Jyotsna Suri, Neha Pruthi, Divya Pandey, Rekha Bharti
OBJECTIVE: To determine the frequency of placenta accreta spectrum (PAS) disorders and to study the demographic profile, risk factors and maternal and fetal outcomes in women with antepartum diagnosis of PAS as compared to women with diagnosis made in the intrapartum period. STUDY DESIGN: Retrospective analysis over a 3-year period of all patients who delivered with PAS. The cases were divided into 2 groups. Group 1 consisted of the patients who were diagnosed during the intra partum period and Group 2 was those diagnosed as PAS by ultrasound in the antepartum period...
March 6, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30878705/verification-of-the-kramers-kronig-relations-between-ultrasonic-attenuation-and-phase-velocity-in-a-finite-spectral-range-for-cfrp-composites
#10
Yu G Sokolovskaya, N B Podymova, A A Karabutov
The aim of this work is to verify applicability of the Kramers-Kronig relations between the attenuation coefficient and phase velocity of longitudinal acoustic waves in carbon fiber reinforced plastic (CFRP) composites in a finite megahertz frequency range. To measure these characteristics, the method of broadband acoustic spectroscopy with a laser source of ultrasound is used. We have experimentally shown that absolute attenuation in CFRPs is determined by both absorption in a polymer matrix and scattering on carbon fibers and gas pores of several tenths of microns in size...
March 5, 2019: Ultrasonics
https://read.qxmd.com/read/30878692/oocyte-quality-and-heat-shock-proteins-in-oocytes-from-bovine-breeds-adapted-to-the-tropics-under-different-conditions-of-environmental-thermal-stress
#11
M B Souza-Cácares, A L L Fialho, W A L Silva, C J T Cardoso, R Pöhland, M I M Martins, F A Melo-Sterza
In order to evaluate the influence of thermal stress on physiological parameters, and the oocyte quality of Girolando (n = 12) and adapted Pantaneira (n = 12) cattle, twelve sessions of ultrasound guided follicular aspiration (OPU) were performed, between January and November 2014 (during dry (May-September) and rainy season (October-April) in Brazil). The recovered cumulus-oocyte complexes (COCs) were selected and classified, according to quality, immediately after OPU. The oocytes were then stored in 3% paraformaldehyd before conducting immunofluorescence analysis under confocal microscopy to identify HSP70 and 90 proteins...
March 7, 2019: Theriogenology
https://read.qxmd.com/read/30878687/diagnostic-d%C3%A2-une-infection-g%C3%A3-nitale-haute-crit%C3%A3-res-cliniques-paracliniques-imagerie-et-c%C3%A5-lioscopie-rpc-infections-g%C3%A3-nitales-hautes-cngof-et-spilf
#12
Amélie Charvériat, Xavier Fritel
The objective of this literature review is to update the recommendations for clinical practice about the diagnosis of Pelvic Inflammatory Disease (PID), microbiologic diagnosis excluded. An adnexal pain or cervical motion tenderness are the signs that allow a positive diagnosis of PID (LE2). Associated signs (fever, leucorrhoea, metrorrhagia) reinforce clinical diagnosis (LE2). In a woman consulting for symptoms compatible with PID, a pelvic clinical examination is recommended (Grade B). In cases of suspected PID, hyperleukocytosis associated with a high C-reactive protein suggests a complicated PID or a differential diagnosis such as acute appendicitis (LE3)...
March 13, 2019: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/30878666/the-4th-st-gallen-eortc-gastrointestinal-cancer-conference-controversial-issues-in-the-multimodal-primary-treatment-of-gastric-junctional-and-oesophageal-adenocarcinoma
#13
REVIEW
Manfred P Lutz, John R Zalcberg, Michel Ducreux, Antoine Adenis, William Allum, Daniela Aust, Fatima Carneiro, Heike I Grabsch, Pierre Laurent-Puig, Florian Lordick, Markus Möhler, Stefan Mönig, Radka Obermannova, Guillaume Piessen, Angela Riddell, Christoph Röcken, Franco Roviello, Paul Magnus Schneider, Stefan Seewald, Elizabeth Smyth, Eric van Cutsem, Marcel Verheij, Anna Dorothea Wagner, Florian Otto
Multimodal primary treatment of localised adenocarcinoma of the stomach, the oesophagus and the oesophagogastric junction (AEG) was reviewed by a multidisciplinary expert panel in a moderated consensus session. Here, we report the key points of the discussion and the resulting recommendations. The exact definition of the tumour location and extent by white light endoscopy in conjunction with computed tomography scans is the backbone for any treatment decision. Their value is limited with respect to the infiltration depth, lymph node involvement and peritoneal involvement...
March 14, 2019: European Journal of Cancer
https://read.qxmd.com/read/30878474/impact-of-intravascular-ultrasound-guided-percutaneous-coronary-intervention-on-long-term-clinical-outcomes-in-patients-undergoing-complex-procedures
#14
Ki Hong Choi, Young Bin Song, Joo Myung Lee, Sang Yoon Lee, Taek Kyu Park, Jeong Hoon Yang, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn
OBJECTIVES: This study sought to determine whether intravascular ultrasound (IVUS) guidance compared with angiographic guidance reduces long-term risk of cardiac death in patients undergoing complex percutaneous coronary intervention (PCI). BACKGROUND: Although IVUS is a useful tool for accurate assessment of lesion profiles and optimal stent implantation, there are limited data on long-term clinical outcomes between IVUS-guided and angiography-guided PCI for patients with complex lesions...
March 9, 2019: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/30878471/intravascular-ultrasound-for-complex-percutaneous-coronary-intervention-a-far-too-complex-way-to-recognition
#15
EDITORIAL
Jose M de la Torre Hernandez
No abstract text is available yet for this article.
March 9, 2019: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/30878375/diagnostic-performance-of-optic-nerve-sheath-diameter-for-predicting-neurologic-outcome-in-post-cardiac-arrest-patients-a-systematic-review-and-meta-analysis
#16
REVIEW
Sun Hwa Lee, Seong Jong Yun
AIMS: We evaluated the diagnostic performance of optic nerve sheath diameter (ONSD) for prediction of neurologic outcome in post-cardiac arrest patients and relative prediction performance according to ONSD measurement modality. DATA SOURCES: PubMed and EMBASE databases were searched for diagnostic accuracy studies that used ocular ultrasound or brain computed tomography (CT) for prediction of neurologic outcome. Bivariate modelling and hierarchical-summary and receiver-operating-characteristic modelling were performed to evaluate diagnostic performance...
March 13, 2019: Resuscitation
https://read.qxmd.com/read/30878348/standardized-magnetic-resonance-imaging-reporting-using-the-prostate-cancer-radiological-estimation-of-change-in-sequential-evaluation-criteria-and-magnetic-resonance-imaging-transrectal-ultrasound-fusion-with-transperineal-saturation-biopsy-to-select-men-on
#17
Svenja Dieffenbacher, Joanne Nyarangi-Dix, Francesco Giganti, David Bonekamp, Claudia Kesch, Maya B Müller-Wolf, Viktoria Schütz, Claudia Gasch, Gencay Hatiboglu, Marcus Hauffe, Albrecht Stenzinger, Stefan Duensing, Heinz-Peter Schlemmer, Caroline M Moore, Markus Hohenfellner, Jan Philipp Radtke
BACKGROUND: Contemporary selection criteria for men with prostate cancer (PC) suitable for active surveillance (AS) are unsatisfactory, leading to high disqualification rates based on tumor misclassification. Conventional biopsy protocols are based on standard 12-core transrectal ultrasound (TRUS) biopsy. OBJECTIVE: To assess the value of magnetic resonance imaging (MRI)/TRUS fusion biopsy over 4-yr follow-up in men on AS for low-risk PC. DESIGN, SETTING, AND PARTICIPANTS: Between 2010 and 2018, a total of 273 men were included...
March 13, 2019: European Urology Focus
https://read.qxmd.com/read/30878322/routine-assessment-of-cerebroplacental-ratio-at-35-37-weeks-gestation-in-the-prediction-of-adverse-perinatal-outcome
#18
Ranjit Akolekar, Anca Ciobanu, Emilie Zingler, Argyro Syngelaki, Kypros H Nicolaides
BACKGROUND: Third trimester studies in selected high-risk pregnancies have reported that low cerebroplacental ratio (CPR), due to high pulsatility index (PI) in the umbilical artery (UA), and or decreased PI in the fetal middle cerebral artery (MCA), is associated with increased risk of adverse perinatal outcomes. OBJECTIVE: To investigate the predictive performance of screening for adverse perinatal outcome by the cerebroplacental ratio (CPR) measured routinely at 35 - 37 weeks' gestation...
March 13, 2019: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/30878275/extracraniofacial-anomalies-in-craniofacial-microsomia-retrospective-analysis-of-991-patients
#19
R W Renkema, C J J M Caron, E Pauws, E B Wolvius, J A M Schipper, W Rooijers, D J Dunaway, C R Forrest, B L Padwa, M J Koudstaal
Craniofacial microsomia (CFM) is characterized by unilateral or bilateral underdevelopment of the facial structures arising from the first and second pharyngeal arches, but extracraniofacial anomalies may also be present. This retrospective study provides an overview of the prevalence, types, and characteristics of extracraniofacial anomalies in patients with CFM. All patients diagnosed with CFM seen at four craniofacial centres were included. The patient charts were reviewed and data on patient characteristics and extracraniofacial anomalies were extracted...
March 13, 2019: International Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/30878165/vitality-tests-for-pulp-diagnosis-of-traumatized-teeth-a-systematic-review
#20
REVIEW
Thiago Farias Rocha Lima, Samara Luize Dos Santos, Tatiana Kelly da Silva Fidalgo, Emmanuel João Nogueira Leal Silva
INTRODUCTION: The objective of this systematic review was to evaluate the efficacy of vitality tests (pulse oximetry and flowmetry) in the pulpal diagnosis of traumatized teeth in comparison with sensibility tests. METHODS: This review was registered in the PROSPERO database (CRD42018097361) and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. An electronic systematic search of the literature was performed in the PubMed (Medline), Scopus, Web of Science, Cochrane Library, Lilacs, and Gray Literature databases and the reference lists of articles published until May 2018...
March 13, 2019: Journal of Endodontics
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