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JOURNAL ARTICLE
Kexin Wang, Licheng Ju, Yulu Song, Lindsay Blair, Kevin Xie, Claire Liu, Anna M Li, Dan Zhu, Feng Xu, Guanshu Liu, Hye-Young Heo, Nirbhay Narayan Yadav, Georg Oeltzschner, Richard A E Edden, Qin Qin, David Olayinka Kamson, Jiadi Xu
PURPOSE: To develop a 3D, high-sensitivity CEST mapping technique based on the 3D stack-of-spirals (SOS) gradient echo readout, the proposed approach was compared with conventional acquisition techniques and evaluated for its efficacy in concurrently mapping of guanidino (Guan) and amide CEST in human brain at 3 T, leveraging the polynomial Lorentzian line-shape fitting (PLOF) method. METHODS: Saturation time and recovery delay were optimized to achieve maximum CEST time efficiency...
May 15, 2024: Magnetic Resonance in Medicine
#2
JOURNAL ARTICLE
Christopher Brown, Sandhitsu Das, Long Xie, Ilya Nasrallah, John Detre, Alice Chen-Plotkin, Leslie Shaw, Corey McMillan, Paul Yushkevich, David Wolk
INTRODUCTION: Typical MRI measures of neurodegeneration have limited sensitivity in early disease stages. Diffusion MRI (dMRI) microstructural measures may allow for detection in preclinical stages. METHODS: Participants had dMRI and either beta-amyloid PET or plasma biomarkers of Alzheimer's pathology within 18 months of MRI. Microstructure was measured in portions of the medial temporal lobe (MTL) with high neurofibrillary tangle (NFT) burden based on a previously developed post mortem 3D-map...
May 15, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#3
JOURNAL ARTICLE
Anna Scholz, Carolyn B McNabb, Laura Bloomfield, Raghav Bhargava, Charlotte Hales, Colin M Dayan, Peter N Taylor, John H Lazarus, Onyebuchi Okosieme, Marian Ludgate, Derek K Jones, D Aled Rees
CONTEXT: Children born to mothers with gestational hypo- or hyperthyroidism may have increased risk of adverse neurodevelopmental outcomes. However, the effects of maternal thyroid status on offspring brain development are unclear. OBJECTIVE: To establish whether adolescent brain morphology is affected by suboptimal gestational thyroid function (SGTF). DESIGN AND SETTING: The Controlled Antenatal Thyroid Screening (CATS) study randomized mothers with SGTF to levothyroxine or no supplementation from ∼12 weeks' gestation...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
#4
JOURNAL ARTICLE
Xiaoshuai Li, Jie Xing, Ying Hui, Huijing Shi, Rui Li, Shun Zhang, Shuohua Chen, Jing Li, Xiaoliang Liang, Yuntao Wu, Pengfei Zhao, Shouling Wu, Zhenchang Wang
OBJECTIVES: To investigate the association of arterial stiffness with brain perfusion, brain tissue volume and cognitive impairment in the general adult population. MATERIALS AND METHODS: This prospective study included 1488 adult participants (age range: 22.8-83.9 years) from the Kailuan study. All participants underwent brachial-ankle pulse wave velocity (PWV) measurement, brain MRI, and Montreal Cognitive Assessment (MoCA). The association of PWV with cerebral blood flow (CBF), brain tissue volume and MoCA score was investigated...
May 2, 2024: Journal of Hypertension
#5
JOURNAL ARTICLE
Aishwarya Ghosh, Sadhana Singh, Monisha S, Tejaswini Jagtap, Thomas Gregor Issac
OBJECTIVES: Aging is a natural process and is often associated with an increased incidence of cognitive impairment. Physical exercise, diet, and leisure activities (music, dance, and art) are some of the lifestyle factors that contribute to healthy aging. The present study aims to explore the differences in cognitive functioning between aging individuals involved in musical activity throughout their lifetime and the ones who were not. MATERIALS AND METHODS: Fifty-one healthy elderly individuals (50-80 years of age) residing in an urban locality were selected for the study from the Tata Longitudinal Study of Aging cohort...
2024: Journal of Neurosciences in Rural Practice
#6
René Labounek, Monica T Bondy, Amy L Paulson, Sandrine Bédard, Mihael Abramovic, Eva Alonso-Ortiz, Nicole T Atcheson, Laura R Barlow, Robert L Barry, Markus Barth, Marco Battiston, Christian Büchel, Matthew D Budde, Virginie Callot, Anna Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostál, Julien Doyon, Adam V Dvorak, Falk Eippert, Karla R Epperson, Kevin S Epperson, Patrick Freund, Jürgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A M Gandini Wheeler-Kingshott, GianCarlo Germani, Guillaume Gilbert, Federico Giove, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomáš Horák, Masaaki Hori, James M Joers, Kouhei Kamiya, Haleh Karbasforoushan, Miloš Keřkovský, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlička, Paul Kuntke, Nyoman D Kurniawan, Slawomir Kusmia, Maria Marcella Laganà, Cornelia Laule, Christine S W Law, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Allan R Martin, Eloy Martinez-Heras, Loan Mattera, Kristin P O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B Parrish, Anna Pichiecchio, Ferran Prados, Àlex Rovira, Marc J Ruitenberg, Rebecca S Samson, Giovanni Savini, Maryam Seif, Alan C Seifert, Alex K Smith, Seth A Smith, Zachary A Smith, Elisabeth Solana, Yuichi Suzuki, George W Tackley, Alexandra Tinnermann, Jan Valošek, Dimitri Van De Ville, Marios C Yiannakas, Kenneth A Weber, Nikolaus Weiskopf, Richard G Wise, Patrik O Wyss, Junqian Xu, Julien Cohen-Adad, Christophe Lenglet, Igor Nestrašil
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e. height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30...
May 1, 2024: bioRxiv
#7
Samantha G Malone, Christal N Davis, Zachary Piserchia, Michael R Setzer, Sylvanus Toikumo, Hang Zhou, Emma L Winterlind, Joel Gelernter, Amy Justice, Lorenzo Leggio, Christopher T Rentsch, Henry R Kranzler, Joshua C Gray
BACKGROUND: The prevalence of co-occurring heavy alcohol consumption and obesity is increasing in the United States. Despite neurobiological overlap in the regulation of alcohol consumption and eating behavior, alcohol- and body mass index (BMI)-related phenotypes show no or minimal genetic correlation. We hypothesized that the lack of genetic correlation is due to mixed effect directions of variants shared by AUD and BMI. METHODS: We applied MiXeR, to investigate shared genetic architecture between AUD and BMI in individuals of European ancestry...
May 5, 2024: medRxiv
#8
JOURNAL ARTICLE
Esra Sefik, Kuaikuai Duan, Yiheng Li, Brittney Sholar, Lindsey Evans, Jordan Pincus, Zeena Ammar, Melissa M Murphy, Cheryl Klaiman, Celine A Saulnier, Stormi L Pulver, Adam E Goldman-Yassen, Ying Guo, Elaine F Walker, Longchuan Li, Jennifer G Mulle, Sarah Shultz
High-impact genetic variants associated with neurodevelopmental disorders provide biologically-defined entry points for mechanistic investigation. The 3q29 deletion (3q29Del) is one such variant, conferring a 40-100-fold increased risk for schizophrenia, as well as high risk for autism and intellectual disability. However, the mechanisms leading to neurodevelopmental disability remain largely unknown. Here, we report the first in vivo quantitative neuroimaging study in individuals with 3q29Del (N = 24) and neurotypical controls (N = 1608) using structural MRI...
May 14, 2024: Molecular Psychiatry
#9
JOURNAL ARTICLE
Nils D Forkert, Sarah J MacEachern, Allison K Duh, Peter Moon, Sarah Lee, Kristen W Yeom
BACKGROUND AND OBJECTIVES: Children with congenital heart diseases (CHDs) have an increased risk of developing neurologic deficits, even in the absence of apparent brain pathology. The aim of this work was to compare quantitative macro- and microstructural properties of subcortical gray matter structures of pediatric CHD patients with normal appearing brain magnetic resonance imaging to healthy controls. METHODS: We retrospectively reviewed children with coarctation of the aorta (COA) and hypoplastic left heart syndrome (HLHS) admitted to our hospital...
May 14, 2024: Clinical Neuroradiology
#10
JOURNAL ARTICLE
Zhongyu Chang, Liping Liu, Liyuan Lin, Gang Wang, Chen Zhang, Hongjun Tian, Wei Liu, Lina Wang, Bin Zhang, Juanjuan Ren, Yu Zhang, Yingying Xie, Xiaotong Du, Xiaotong Wei, Luli Wei, Yun Luo, Haoyang Dong, Xin Li, Zhen Zhao, Meng Liang, Congpei Zhang, Xijin Wang, Chunshui Yu, Wen Qin, Huaigui Liu
OBJECTIVE: Although extensive structural and functional abnormalities have been reported in schizophrenia, the gray matter volume (GMV) covariance of the amygdala remain unknown. The amygdala contains several subregions with different connection patterns and functions, but it is unclear whether the GMV covariance of these subregions are selectively affected in schizophrenia. METHODS: To address this issue, we compared the GMV covariance of each amygdala subregion between 807 schizophrenia patients and 845 healthy controls from 11 centers...
2024: Frontiers in Psychiatry
#11
JOURNAL ARTICLE
Viktoriya Vitkova, Dominique Ristori, Guy Cheron, Ariane Bazan, Ana Maria Cebolla
In this study, we investigated the electrical brain responses in a high-density EEG array (64 electrodes) elicited specifically by the word memory cue in the Think/No-Think paradigm in 46 participants. In a first step, we corroborated previous findings demonstrating sustained and reduced brain electrical frontal and parietal late potentials elicited by memory cues following the No-Think (NT) instructions as compared to the Think (T) instructions. The topographical analysis revealed that such reduction was significant 1000 ms after memory cue onset and that it was long-lasting for 1000 ms...
May 13, 2024: Scientific Reports
#12
JOURNAL ARTICLE
Zaineb Amor, Philippe Ciuciu, Chaithya G R, Guillaume Daval-Frérot, Franck Mauconduit, Bertrand Thirion, Alexandre Vignaud
The quest for higher spatial and/or temporal resolution in functional MRI (fMRI) while preserving a sufficient temporal signal-to-noise ratio (tSNR) has generated a tremendous amount of methodological contributions in the last decade ranging from Cartesian vs. non-Cartesian readouts, 2D vs. 3D acquisition strategies, parallel imaging and/or compressed sensing (CS) accelerations and simultaneous multi-slice acquisitions to cite a few. In this paper, we investigate the use of a finely tuned version of 3D-SPARKLING...
2024: PloS One
#13
EDITORIAL
Donato Liloia, Tommaso Costa, Franco Cauda, Jordi Manuello
The advent of structural magnetic resonance imaging (sMRI) at the end of the 20th century opened the way toward a deeper understanding of the neurophysiology of psychiatric disorders, substantiating regional structural abnormalities underlying this group of clinical conditions. However, despite abundant and flourishing scientific research, sMRI methodologies are not currently integrated into daily diagnostic practice. One reason behind this failed translation may be the prevailing approach to logical reasoning in neuroimaging: The forward inference via frequentist-based statistics...
May 13, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
#14
JOURNAL ARTICLE
Nathaniel E Anderson, J Michael Maurer, David Stephenson, Keith Harenski, Michael Caldwell, Greg Van Rybroek, Kent A Kiehl
Substance use disorders among juveniles are a major public health concern and are often intertwined with other psychosocial risk factors including antisocial behavior. Identifying etiological risks and mechanisms promoting substance use disorders remains a high priority for informing more focused interventions in high-risk populations. The present study examined brain gray matter structure in relation to substance use severity among n = 152 high-risk, incarcerated boys (aged 14-20). Substance use severity was positively associated with gray matter volume across several frontal/striatal brain regions including amygdala, pallidum, putamen, insula, and orbitofrontal cortex...
May 13, 2024: Development and Psychopathology
#15
COMMENT
Karel Scheepstra, Mark Mizee, Dennis Wever, Cheng-Chih Hsiao, Lin Zhang, Dick Swaab, Jörg Hamann, Inge Huitinga
Inflammation is a prominent hypothesis in the neurobiology of depression. In our transcriptomic profiling study of microglia in chronic major depressive disorder (MDD), we revealed a distinct disease-associated microglia (DAM) transcriptomic profile exclusively found in cortical gray matter, that we have designated DepDAM. These DepDAM revealed an immune-suppressed state, with a possible upstream mechanism for microglial suppression, by upregulation of CD200 and CD47 ("don't eat me signals") located on synapses...
2024: Neuroscience insights
#16
JOURNAL ARTICLE
Fenglin Xiao, Lili Zhou, Yan Li, Chaoyang Zhang, Ying Liu, Huan Yu, Xiaoping Li, Chunyu Wang, Xinxin Yin, Xin Gao
OBJECTIVE: This study aims to compare gray matter volume changes in patients with chronic kidney disease (CKD) undergoing peritoneal dialysis (PD) and hemodialysis (HD) using voxel-based morphometry (VBM). METHODS: A total of 27 PD patients, 25 HD patients, and 42 healthy controls were included. VBM analysis was performed, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment Scale (MoCA). The correlation between cognitive function and changes in brain gray matter volume was analyzed...
2024: Frontiers in Neuroscience
#17
JOURNAL ARTICLE
Victor Fritz, Sabine Eisele, Petros Martirosian, Jürgen Machann, Fritz Schick
OBJECTIVE: To prepare and analyze soy-lecithin-agar gels for non-toxic relaxometry phantoms with tissue-like relaxation times at 3T. METHODS: Phantoms mimicking the relaxation times of various tissues (gray and white matter, kidney cortex and medulla, spleen, muscle, liver) were built and tested with a clinical 3T whole-body MR scanner. Simple equations were derived to calculate the appropriate concentrations of soy lecithin and agar in aqueous solutions to achieve the desired relaxation times...
May 11, 2024: Magma
#18
JOURNAL ARTICLE
Andrey Mikhailov, Yoshiyuki Sankai
Growing demand for therapeutic tissue repair recurrently focusses scientists' attention on critical assessment of postmortal collection of live cells, especially stem cells. Our study aimed to assess the survival of neuronal progenitors in postmortal spinal cord and their differentiation potential. Postmortal samples of spinal cords were obtained from human-sized animals (goats) at 6, 12, 24, 36, and 54 h after slaughter. Samples were studied by immunohistology, differentiation assay, Western blot and flow cytometry for the presence and location of GD2-positive neural progenitors and their susceptibility to cell death...
April 25, 2024: International Journal of Molecular Sciences
#19
JOURNAL ARTICLE
Irina Chadaeva, Rimma Kozhemyakina, Svetlana Shikhevich, Anton Bogomolov, Ekaterina Kondratyuk, Dmitry Oshchepkov, Yuriy L Orlov, Arcady L Markel
The process of domestication, despite its short duration as it compared with the time scale of the natural evolutionary process, has caused rapid and substantial changes in the phenotype of domestic animal species. Nonetheless, the genetic mechanisms underlying these changes remain poorly understood. The present study deals with an analysis of the transcriptomes from four brain regions of gray rats ( Rattus norvegicus ), serving as an experimental model object of domestication. We compared gene expression profiles in the hypothalamus, hippocampus, periaqueductal gray matter, and the midbrain tegmental region between tame domesticated and aggressive gray rats and revealed subdivisions of differentially expressed genes by principal components analysis that explain the main part of differentially gene expression variance...
April 23, 2024: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
PURPOSE: The objective of this research was to examine changes in the neural networks of both gray and white matter in individuals with obstructive sleep apnea (OSA) in comparison to those without the condition, employing a comprehensive multilayer network analysis. METHODS: Patients meeting the criteria for OSA were recruited through polysomnography, while a control group of healthy individuals matched for age and sex was also assembled. Utilizing T1-weighted imaging, a morphometric similarity network was crafted to represent gray matter, while diffusion tensor imaging provided structural connectivity for constructing a white matter network...
May 11, 2024: Sleep & Breathing
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