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JOURNAL ARTICLE
Samuel D Chauvin, Shoichiro Ando, Joe A Holley, Atsushi Sugie, Fang R Zhao, Subhajit Poddar, Rei Kato, Cathrine A Miner, Yohei Nitta, Siddharth R Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N Artyomov, David C Schultz, P Toby Coates, Elisha D O Roberson, Yasmine Belkaid, Roger A Greenberg, Sara Cherry, Michaela U Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J Miner
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3'-5' DNA exonuclease in mammals. C-terminal TREX1 variants cause an adult-onset SVD known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL or RVCL-S). In RVCL, an aberrant, C-terminally truncated TREX1 mislocalizes to the nucleus due to deletion of its ER-anchoring domain...
June 1, 2024: Nature Communications
#42
JOURNAL ARTICLE
Jixian Mao, Yujie Gao, Zong Meng
In this paper, two emulsion systems with high and low solid fat contents were prepared from 20 % water phase and 80 % oil phase by adjusting the palm oil/palm stearin/soybean oil ratio. Different ultrasonic power and time were used for the pretreatment of emulsion with different solid fat content, and the application characteristics of ultrasonic in W/O emulsions were explored and evaluated. Directly using high-intensity ultrasound to prepare fatty emulsions would weaken the hardness and storage modulus G' of the samples...
July 2024: Food Research International
#43
JOURNAL ARTICLE
Gisela S Costa, Ramon S Rocha, Mônica Q Freitas, Eliane T Mársico, Maria Teresa P S Clerici, Elane S Prudêncio, Tatiana C Pimentel, Erick A Esmerino, Adriano G Cruz
The effect of the substitution of emulsifying salt by the young bamboo flour (BF) (0, 25, 50, 75, 100 % w/w) on requeijão cremoso processed cheese [REQ, REQ 25, REQ 75 REQ 100]) processing was investigated. Gross composition, calcium and sodium values, functional properties (melting rate), color parameters (L, a*, b*, C*, and Whiteness Index, WI), texture profile, fatty acid profile, volatile organic compounds (VOCs), and sensory profiling were evaluated. No effect was observed on the gross composition; however, sodium and melting rate values were decreased, and calcium values presented the opposite behavior...
July 2024: Food Research International
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JOURNAL ARTICLE
Filipa Teixeira, Ana Margarida Silva, Stefania Sut, Stefano Dall'Acqua, Oscar L Ramos, Alessandra B Ribeiro, Ricardo Ferraz, Cristina Delerue-Matos, Francisca Rodrigues
Lycium barbarum L. berries have a remarkable chemical composition and extensive biological activities, being a valuable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extraction (UAE) of goji berries using a Response Surface Methodology approach and establish the intestinal permeation of the principal pro-healthy compounds...
July 2024: Food Research International
#45
JOURNAL ARTICLE
Min-Ji Keem, Beom-Geun Jo, Sang Heon Lee, Tae-Young Kim, Young Suk Jung, Eun-Ju Jeong, Ki Hyun Kim, Su-Nam Kim, Min Hye Yang
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Wikstroemia has been extensively utilized in traditional Chinese medicine (TCM) for the management of conditions such as coughs, edema, arthritis, and bronchitis. Studies have indicated that the crude extracts of Wikstroemia exhibit anti-inflammatory, anti-allergy, anti-aging, skin psoriasis, anti-cancer, and antiviral properties. In addition, these extracts are known to contain bioactive substances, including flavonoids, coumarins, and lignans...
May 30, 2024: Journal of Ethnopharmacology
#46
JOURNAL ARTICLE
Laxman Singh, Basant Singh, Indra Dutt Bhatt
Cyanidin-3-O-galactoside (Cy3-gal) is the most widespread anthocyanin that has been found to be applicable to nutraceutical and pharmaceutical ingredients. Nevertheless, the process of separation and purification, susceptibilities to heat, and pH inactivation present some limitations. In the present study, natural deep eutectic solvents (NADES) with an ultrasonic-assisted extraction method were briefly studied, and the recovery of Cy3-gal from Rhododendron arboreum was highlighted. The NADES, consisting of choline chloride and oxalic acid (1:1), was screened out as an extractant, and single-factor experiments combined with a two-site kinetic model were employed to describe the extraction process...
May 21, 2024: Food Chemistry
#47
JOURNAL ARTICLE
Liz E Lescano, Mario O Salazar, Ricardo L E Furlan
The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thiocyanate as a source of bioactive compounds is described. The impact of the reaction on the chemical composition of the mixtures was qualitatively demonstrated through GC-MS, utilizing univariate and multivariate analysis. The reaction transformed most of the components in the natural mixtures, thereby expanding the chemical diversity of the mixtures. Changes in inhibition properties between natural and CEEOs were demonstrated through acetylcholinesterase TLC autography, resulting in a threefold increase in the number of positive events due to the modification process...
June 1, 2024: Natural Products and Bioprospecting
#48
JOURNAL ARTICLE
Gopinadh Konda, Jasti S Chowdary, C Gnanaseelan, Naresh Krishna Vissa, Anant Parekh
India experienced several unprecedented floods in the recent decades. The increase in the extreme rainfall events (EREs) is the primary cause for these floods, manifesting its societal impacts. The daily downscaled and bias corrected (DBC) Coupled Model Intercomparison Project Phase 6 (CMIP6) rainfall and sea surface temperature (SST) are prepared for the Indian region and are utilized to examine the characteristics of EREs. The DBC products capture the characteristic features of EREs for the baseline period, which inspired us to assess the EREs over India in CMIP6 future projections...
May 31, 2024: Scientific Reports
#49
JOURNAL ARTICLE
Yingzhang Shi, Peng Li, Huiling Chen, Zhiwen Wang, Yujie Song, Yu Tang, Sen Lin, Zhiyang Yu, Ling Wu, Jimmy C Yu, Xianzhi Fu
Adsorption and activation of C-H bonds by photocatalysts are crucial for the efficient conversion of C-H bonds to produce high-value chemicals. Nevertheless, the delivery of surface-active oxygen species for C-H bond oxygenation inevitably needs to overcome obstacles due to the separated active centers, which suppresses the catalytic efficiency. Herein, Ni dopants are introduced into a monolayer Bi2 WO6 to create cascaded active units consisting of unsaturated W atoms and Bi/O frustrated Lewis pairs. Experimental characterizations and density functional theory calculations reveal that these special sites can establish an efficient and controllable C-H bond oxidation process...
May 31, 2024: Nature Communications
#50
JOURNAL ARTICLE
Sandra T F Tsoi, Cadmon Lim, Ronald C W Ma, Eric S H Lau, Baoqi Fan, Elaine Chow, Alice P S Kong, Juliana C N Chan, Andrea O Y Luk
AIMS: Asians have a high prevalence of young-onset diabetes, but the pattern of monogenic diabetes is unknown. We aimed to determine the prevalence of monogenic diabetes in Chinese patients with young-onset diabetes and compare the clinical characteristics and outcome between patients with and without monogenic diabetes. MATERIALS AND METHODS: We sequenced a targeted panel of 33 genes related to monogenic diabetes in 1021 Chinese patients with non-type 1 diabetes diagnosed at age ≤40 years...
July 2024: Diabetes/metabolism Research and Reviews
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JOURNAL ARTICLE
Xiaoming Wen, Jingke Fu, Yue Tian, Jianyong Gao, Yingchun Zhu
Sonography with its non-invasive and deep tissue-penetrating characteristics, not only contributes to promising developments in clinical disease diagnosis but also obtains acknowledgments as a prospective therapeutic approach in the field of tumor treatment. However, it remains a challenge for sonography simultaneously to achieve efficient imaging and therapeutic functionality. Here, we present an innovative integrated diagnosis and treatment paradigm by developing the nanomedicine of percarbamide-bromide-mesoporous organosilica spheres (MOS) with RGD peptide modification (PBMR) by loading percarbamide and bromide in MOS which were prepared by a one-step O/W microemulsion method...
May 31, 2024: Journal of Biomaterials Applications
#52
EDITORIAL
Mikel Gray
No abstract text is available yet for this article.
May 2024: Journal of Wound, Ostomy, and Continence Nursing
#53
JOURNAL ARTICLE
Shitong Liu, Jun Wang, Yang Liu, Baojun Yang, Maoxin Hong, Shichao Yu, Guanzhou Qiu
Red mud (RM) is a typical bulk solid waste with Fe/Al/Si/Ca-rich characteristics that has been used to prepare various heterogeneous catalysts such as iron-based catalysts and supported catalysts. Prussian blue analogues (PBA) is a low-cost, environmentally friendly, and active site rich iron-based metal organic framework, but its catalytic properties are adversely affected by their easy aggregation. In this study, nickel-doped RM-based PBA (RM-Ni PBA) was synthesized by acid dissolution-coprecipitation method for the degradation of ciprofloxacin (CIP)...
May 31, 2024: Environmental Science and Pollution Research International
#54
JOURNAL ARTICLE
F Oliveri, M J H Van Oort, I Al Amri, B O Bingen, F Van der Kley, J W Jukema, A Jurado-Roman, J Montero Cabezas
BACKGROUND: Percutaneous coronary intervention (PCI) on severely calcified coronary lesions is challenging. Coronary calcified nodule (CN) refers to an eccentric and protruding coronary calcification associated with plaque vulnerability and adverse clinical events. This study aims to conduct an extensive review of CNs, focusing on its prognostic impact in comparison with nonnodular coronary calcification (N-CN). METHOD: A systematic literature review on PubMed, MEDLINE, and EMBASE databases was conducted for relevant articles...
June 1, 2024: Journal of Cardiovascular Medicine
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JOURNAL ARTICLE
Robert Luke Pecha, Fares Ayoub, Ankur Patel, Abdullah Muftah, Michael W Wright, Mai A Khalaf, Mohamed O Othman
BACKGROUND: Among patients with cirrhosis and pre-malignant or early malignant mucosal lesions, surgical intervention carries a much higher bleeding risk. When such lesions are discovered, endoscopic submucosal dissection (ESD) may offer curative therapy with lower risks than surgery and improved outcomes compared to traditional endoscopic resection. AIM: To evaluate the outcomes of ESD in patients with cirrhosis. METHODS: Patients with cirrhosis undergoing ESD between July 2015 and August 2022 were retrospectively matched in 1:2 fashion to controls based on lesion location, size, and anticoagulation use...
May 27, 2024: World Journal of Hepatology
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JOURNAL ARTICLE
Paul S de Vries, Matthew P Conomos, Kuldeep Singh, Christopher J Nicholson, Deepti Jain, Natalie R Hasbani, Wanlin Jiang, Sujin Lee, Christian L Lino Cardenas, Sharon M Lutz, Doris Wong, Xiuqing Guo, Jie Yao, Erica P Young, Catherine Tcheandjieu, Austin T Hilliard, Joshua C Bis, Lawrence F Bielak, Michael R Brown, Shaila Musharoff, Shoa L Clarke, James G Terry, Nicholette D Palmer, Lisa R Yanek, Huichun Xu, Nancy Heard-Costa, Jennifer Wessel, Margaret Sunitha Selvaraj, Rebecca H Li, Xiao Sun, Adam W Turner, Adrienne M Stilp, Alyna Khan, Anne B Newman, Asif Rasheed, Barry I Freedman, Brian G Kral, Caitlin P McHugh, Chani Hodonsky, Danish Saleheen, David M Herrington, David R Jacobs, Deborah A Nickerson, Eric Boerwinkle, Fei Fei Wang, Gerardo Heiss, Goo Jun, Greg L Kinney, Haakon H Sigurslid, HarshaVardhan Doddapaneni, Ira M Hall, Isabela M Bensenor, Jai Broome, James D Crapo, James G Wilson, Jennifer A Smith, John Blangero, Jose D Vargas, Jose Verdezoto Mosquera, Joshua D Smith, Karine A Viaud-Martinez, Kathleen A Ryan, Kendra A Young, Kent D Taylor, Leslie A Lange, Leslie S Emery, Marcio S Bittencourt, Matthew J Budoff, May E Montasser, Miao Yu, Michael C Mahaney, Mohammed S Mahamdeh, Myriam Fornage, Nora Franceschini, Paulo A Lotufo, Pradeep Natarajan, Quenna Wong, Rasika A Mathias, Richard A Gibbs, Ron Do, Roxana Mehran, Russell P Tracy, Ryan W Kim, Sarah C Nelson, Scott M Damrauer, Sharon L R Kardia, Stephen S Rich, Valentin Fuster, Valerio Napolioni, Wei Zhao, Wenjie Tian, Xianyong Yin, Yuan-I Min, Alisa K Manning, Gina Peloso, Tanika N Kelly, Christopher J O'Donnell, Alanna C Morrison, Joanne E Curran, Warren M Zapol, Donald W Bowden, Lewis C Becker, Adolfo Correa, Braxton D Mitchell, Bruce M Psaty, John Jeffrey Carr, Alexandre C Pereira, Themistocles L Assimes, Nathan O Stitziel, John E Hokanson, Cecelia A Laurie, Jerome I Rotter, Ramachandran S Vasan, Wendy S Post, Patricia A Peyser, Clint L Miller, Rajeev Malhotra
Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC ( ARSE and MMP16 ), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying or osteogenic phenotype...
December 2023: Nat Cardiovasc Res
#57
JOURNAL ARTICLE
L C Chow, B S Lee, S O Tang, E W Loh, S C Ng, X Y Tan, M N Ahmad Noordin, G B Ong, L C Chew
INTRODUCTION: Thalassaemia is one of the major health problems in Malaysia. With safe blood transfusion regime, the lifespan of patients with transfusion-dependent thalassaemia (TDT) has improved but at the cost of a higher risk of developing endocrine disorders. It is crucial for us to monitor the iron overload to prevent end organ damage. This study aims to evaluate the iron burden and prevalence of endocrinopathies in patients with TDT in Sarawak. MATERIALS AND METHODS: This retrospective cohort study was conducted between January 2020 to June 2020 in six government hospitals in Sarawak...
May 2024: Medical Journal of Malaysia
#58
JOURNAL ARTICLE
Heping Liu, Naliang Jing, Fengfeng Li, Keyue Wang, Jing Tang, Qin Zhao, Yipeng Zhang, Hamza Armghan Noushahi, Ran Xu, Xuekui Wang, Wenjun Zhu, Shengqiu Feng, Shaohua Shu, Zhinan Mei
Wolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with therapies. Nowadays, the unknown PA biosynthesis leads to difficulties in increasing its content in W. cocos. Herein, we report sequencing, assembling, and characterization of the genome and several transcriptomes of W. cocos. Sequence mining determined candidate genes that encode lanosterol synthase, sterol O-acyltransferase, and sterol C-24 methyltransferase likely involved in the steps from lanosterol to PA...
May 30, 2024: Communications Biology
#59
JOURNAL ARTICLE
Jin Li, Dan Cai, Lei Chen, Lijie Zhu, Shilin Liu, Jie Cai, Guozhen Wang, Bowen Wang, Wenping Ding
The hydrophilicity of gelatin films obviously limits their application. In this work, novel protonated chitin nanofiber was prepared with green methods, surficial deacetylation combined with acidic and mechanical treatment. Composite films with excellent water and oxygen barrier properties were successfully prepared by blending O/W Pickering emulsions stabilized by chitin nanofibers with gelatin substrates. The films were characterized by Fourier-transform infrared, X-ray diffraction, mechanical properties, water and oxygen permeability, moisture content, water solubility, water contact angle and optical properties...
May 28, 2024: International Journal of Biological Macromolecules
#60
JOURNAL ARTICLE
Rong Zheng, Mikayla Dunlap, Georg O M Bobkov, Carlos Gonzalez-Figueroa, Khushali J Patel, Jingyi Lyu, Samuel E Harvey, Tracey W Chan, Giovanni Quinones-Valdez, Mudra Choudhury, Charlotte A Le Roux, Mason D Bartels, Amy Vuong, Ryan A Flynn, Howard Y Chang, Eric L Van Nostrand, Xinshu Xiao, Chonghui Cheng
RNA splicing is pivotal in post-transcriptional gene regulation, yet the exponential expansion of intron length in humans poses a challenge for accurate splicing. Here, we identify hnRNPM as an essential RNA-binding protein that suppresses cryptic splicing through binding to deep introns, maintaining human transcriptome integrity. Long interspersed nuclear elements (LINEs) in introns harbor numerous pseudo splice sites. hnRNPM preferentially binds at intronic LINEs to repress pseudo splice site usage for cryptic splicing...
May 22, 2024: Molecular Cell
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