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Ulcerative colite

Laëtitia Kermarrec, Nour Eissa, Hongxing Wang, Kunal Kapoor, Abdoulaye Diarra, Abdelilah S Gounni, Charles N Bernstein, Jean-Eric Ghia
BACKGROUND AND PURPOSE: Alteration of the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin-3E (SEMA3E), a secreted guidance protein, regulates various immune responses. EXPERIMENTAL APPROACH: We investigated SEMA3E expression in colonic biopsies of active UC patients and its mechanisms in Sema3e-/- mice using a UC model of experimental colitis. KEY-RESULTS: SEMA3E level was decreased in active UC patients and negatively correlated with pro-inflammatory mediators...
February 8, 2019: British Journal of Pharmacology
Dong-Hoon Yang, Jihun Kim, Eun Mi Song, Kiju Chang, Sun-Ho Lee, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
BACKGROUND: The feasibility of endoscopic submucosal dissection (ESD) as a treatment option for dysplasia in ulcerative colitis (UC) has been reported but the associated therapeutic decision-making and clinical outcomes have not been extensively investigated. METHODS: We retrospectively reviewed 25 UC patients who were referred for potential ESD of non-polypoid or sessile dysplasia. We analyzed the treatment decisions and the ESD and colectomy outcomes for this patient group...
February 6, 2019: Journal of Gastroenterology and Hepatology
Satoshi Kinoshita, Toshihiro Nishizawa, Naohisa Yahagi, Toshio Uraoka
Patients with ulcerative colitis have an increased risk of developing colorectal cancer. This risk has been estimated to reach about 7% at 20 years of disease, 7-14% at 25 years, and as high as 30% after 35 years. The guidelines for the management of inflammatory bowel disease recommend endoscopic resection of circumscribed dysplasia and ongoing colonoscopic surveillance as a reasonable strategy in patients with ulcerative colitis. Submucosal fibrosis due to background inflammation could hamper adequate lifting and endoscopic treatment...
2019: Digestion
Vijay L Kumar, Abhimanu Pandey, Sneh Verma, Prasenjit Das
Calotropis procera, a latex producing plant is known to possess medicinal properties including its beneficial effect in gastrointestinal disorders. The anti-inflammatory effect of its latex in various experimental models is noteworthy and in light of this the present study was carried out with an objective to evaluate its efficacy in ulcerative colitis, an inflammatory condition of the colon. Colitis was induced in rats by acetic acid and the rats were divided into four groups where one group served as experimental control and the other groups were treated with two doses of methanol extract of dried latex of C...
January 2019: Biomedicine & Pharmacotherapy
Yuan-Ping Yang, Qiao-Yun Tong, Shi-Hua Zheng, Ming-Dong Zhou, You-Meng Zeng, Ting-Ting Zhou
The anti-inflammatory activities of fucoxanthin, a marine carotenoid derived from the macroalgae and microalgae, have been demonstrated in the previous studies. However, the effect of fucoxanthin on ulcerative colitis (UC), an inflammatory bowel disease, was still unclear. In this study, we evaluated the in vivo anti-inflammatory effect of fucoxanthin on dextran sulfate sodium(DSS)-induced colitis in mice. Fucoxanthin at the doses of 50 and 100 mg/kg/day significantly protected against DSS-induced gradual loss of body weight, exhibited inhibitory effects on the DSS-induced increase of disease activity index and colon shortening...
November 29, 2018: Natural Product Research
Xavier Escoté
In a recent issue of Clinical Science , Prieto-Vicente et al. [ Clin. Sci. (2018) 132 , 985-1001] have smartly demonstrated a potential new use of cardiotrophin-1 (CT-1) to treat and palliate an inflammatory bowel disease such as ulcerative colitis. In that work, authors report that in ulcerative colitic mice, administration of exogenous recombinant CT-1 (rCT-1) promotes lower colon damage and lower disease activity index, reducing systemic levels of tumor necrosis factor α (TNF-α) and also diminishing TNF-α expression in colon together with the reduction in other common inflammation markers...
October 31, 2018: Clinical Science (1979-)
Rajkumar Cheluvappa
The appendix contains copious lymphoid tissue and is constantly exposed to gut flora. Appendicitis followed by appendectomy (AA), when done at a young age, prevents or significantly ameliorates inflammatory bowel diseases (IBDs) in later life. Inflammatory bowel disease comprises Crohn's disease and ulcerative colitis. Our unique murine AA model is the only existing experimental model of AA. Herein, the appendiceal pathology closely resembles the pathological features of human appendicitis. Our AA model protects against experimental colitis in an age-, bacteria- and antigen-dependent manner...
October 16, 2018: Inflammatory Bowel Diseases
Mao-Cheng Sun, Fu-Cheng Zhang, Xue Yin, Bi-Jun Cheng, Chang-Hui Zhao, Yan-Ling Wang, Zheng-Zhe Zhang, Hong-Wei Hao, Tie-Hua Zhang, Hai-Qing Ye
Probiotics are considered to be a potential treatment for ulcerative colitis (UC). The aim of this study was to compare the preventive effect of a space flight-induced mutant L. reuteri F-9-35 and its wild type on UC in vivo. Female mice were randomly assigned to five groups: one normal and four colitic. Mice from colitis groups were daily gavaged with 0.2 mL 12% (w/v) skim milk containing the mutant or wild type (1 × 1011 CFU/mL), skim milk alone or distilled water for the whole experiment period, starting 7 days before colitis induction...
October 2018: Journal of Food Science
Huatuo Zhu, Shujun Huang, Min Yue, Wenguo Chen, Chao Lu, Xinhe Lou, Chunxiao Li, Guodong Shan, Hongtan Chen, Xiaowei Xu, Guoqiang Xu, Lihua Chen
BACKGROUND: Ulcerative colitis (UC) is an idiopathic colonic mucosal disease, and its pathogenesis has not been fully understood. Up-frameshift protein 1 (UPF1) is a potential molecule for UC predicted by a computational approach. AIM: The present study aimed to validate the underlying mechanism of UPF1 in UC. METHODS: UPF1 expression was detected by qRT-PCR, western blotting, and immunohistochemistry in dextran sulfate sodium-induced colitis in mice...
October 2018: Digestive Diseases and Sciences
Shraddha Gulati, Andrew Emmanuel, Margaret Burt, Patrick Dubois, Bu'Hussain Hayee, Amyn Haji
Background: The SCENIC consensus statement recommends endoscopic resection of all visible dysplasia in inflammatory bowel disease, but patients with large or complex lesions may still be advised to have colectomy. This article presents outcomes for large nonpolypoid resections associated with colitis at our institution. Methods: Data including demographics, clinical history, lesion characteristics, method of resection, and postresection surveillance were collected prospectively in patients with visible lesions within colitic mucosa from January 2011 to November 2016...
May 18, 2018: Inflammatory Bowel Diseases
Shakeeb A Wazea, Walaa Wadie, Ashraf K Bahgat, Hanan S El-Abhar
Vagal stimulation controls systemic inflammation and modulates the immune response in different inflammatory conditions, including inflammatory bowel diseases (IBD). The released acetylcholine binds to alpha-7 nicotinic acetylcholine receptor (α7 nAChR) to suppress pro-inflammatory cytokines. This provides a new range of potential therapeutic approaches for controlling inflammatory responses. The present study aimed to assess whether galantamine (Galan) anti-inflammatory action involves α7 nAChR in a 2,4,6-trinitrobenzene sulfonic acid (TNBS) model of colitis and to estimate its possible molecular pathways...
March 23, 2018: Scientific Reports
Vanessa Prieto-Vicente, Ana I Sánchez-Garrido, Víctor Blanco-Gozalo, Miguel Arévalo, Enrique García-Sánchez, Daniel López-Montañés, Yaremi Quiros, Francisco J López-Hernández, Antonio Rodríguez-Pérez, José M López-Novoa
Cardiotrophin-1 (CT-1) holds potent anti-inflammatory, cytoprotective, and anti-apoptotic effects in the liver, kidneys, and heart. In the present study, the role of endogenous CT-1 and the effect of exogenous CT-1 were evaluated in experimental ulcerative colitis. Colitis was induced in CT-1 knockout and wild-type (WT) mice by administration of dextran sulphate sodium (DSS) in the drinking water during 7 days. CT-1 knockout mice showed higher colon damage and disease severity than WT mice. In addition, CT-1 (200 µg/kg/day, iv) or vehicle (as control) was administered during 3 days to WT, colitic mice, starting on day 4 after initiation of DSS...
May 23, 2018: Clinical Science (1979-)
Baoren Zhang, Yi Liu, Xu Lan, Xiaoxi Xu, Xiaoning Zhang, Xiang Li, Yiming Zhao, Guang Li, Caigan Du, Shanzheng Lu, Hao Wang
BACKGROUND: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of colon. It is commonly believed that the imbalance of immune system and overwhelming production of cytokines are involved in the pathogenesis of UC. Recent studies demonstrated that interleukin-35 (IL-35), a key player in the regulation of inflammation, has been identified as potential therapeutic target to treat UC. However, conventional intravenous administration is costly and inconvenient...
March 20, 2018: Journal of Translational Medicine
Jordi Gordillo, Yamile Zabana, Esther Garcia-Planella, Míriam Mañosa, Jordina Llaó, Ignasi Gich, Laura Marín, Justyna Szafranska, Sergio Sáinz, Xavier Bessa, Eduard Cabré, Eugeni Domènech
Background: Patients with ulcerative colitis (UC) have an increased risk of colorectal cancer. Scarce data regarding the development of adenomas in these patients are available both for normal and colitic mucosa. Objective: The objective of this article is to evaluate the prevalence of adenomatous polyps and associated risk factors in patients with UC. Methods: Patients with UC were identified from the databases of two tertiary referral centers...
March 2018: United European Gastroenterology Journal
Masumi Kumakura, Toshiro Ogura, Yu Muta, Tetsuya Ito, Azusa Yamamoto, Kunihiko Amano, Toru Ishiguro, Minoru Fukuchi, Erito Mochiki, Hideyuki Ishida
We report the case of a 55-year-old man who successfully underwent resection of a recurrence of ulcerative colitis(UC)- associated colon cancer located in the pancreatic body and left kidney. The patient had undergone an emergency laparotomy (total proctocolectomy with stapled ileal-pouch anal anastomosis)for the treatment of a descending colon cancer with retroperitoneal penetration associated with UC at the age of 50 years. At that time, histological examinations revealed a mucinous carcinoma that was classified as Stage II colon cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Cynthia Reinoso Webb, Hendrik den Bakker, Iurii Koboziev, Yava Jones-Hall, Kameswara Rao Kottapalli, Dmitry Ostanin, Kathryn L Furr, Qinghui Mu, Xin M Luo, Matthew B Grisham
One of the best characterized mouse models of the inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) is the CD4+CD45RBhigh T cell transfer model of chronic colitis. Following our relocation to Texas Tech University Health Sciences Center (TTUHSC), we observed a dramatic reduction in the incidence of moderate-to-severe colitis from a 16-year historical average of 90% at Louisiana State University Health Sciences Center (LSUHSC) to <30% at TTUHSC. We hypothesized that differences in the commensal microbiota at the 2 institutions may account for the differences in susceptibility to T cell-induced colitis...
January 18, 2018: Inflammatory Bowel Diseases
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
Atsushi Irie, Takahisa Imamura, Yayoi Michibata, Ttatsuko Kubo, Naoki Takeda, Isao Shibuya, Shinji Sogo, Kimi Araki, Yasuharu Nishimura
BACKGROUND: Homozygous HLA-DR4/I-E transgenic mice (tgm) spontaneously developed colitis similar to human ulcerative colitis. We explored whether endoplasmic reticulum stress in colonic epithelial cells due to overexpression of HLA-DR4/I-E was involved in the pathogenesis of colitis. METHODS: Major histocompatibility complex class II transactivator-knockout (CIITAKO) background tgm were established to test the involvement of HLA-DR4/I-E expression in the pathogenesis of colitis...
December 2017: Inflammatory Bowel Diseases
Toshiaki Tanaka, Takashi Kobunai, Yoko Yamamoto, Shigenobu Emoto, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Kazushige Kawai, Keisuke Hata, Hiroaki Nozawa, Toshiaki Watanabe
BACKGROUND: Patients with ulcerative colitis (UC) are at risk of UC-associated colorectal cancer (CRC); however, little is known about genetic alterations occurring during UC carcinogenesis. We examined mutational changes in patients with colitic cancer and the features that differed between the carcinogenesis of UC and sporadic CRC. MATERIAL AND METHODS: Specimens were obtained from the non-neoplastic mucosa and cancer cells of 12 patients with colitic cancer. The mutational rate of oncogenes in colitic cancer was analyzed and compared to that of oncogenes in sporadic CRC...
September 2017: Cancer Genomics & Proteomics
Iosif Beintaris, Matt Rutter
Inflammatory bowel disease (IBD) (ulcerative colitis (UC) and Crohn's disease (CD)) is a chronic relapsing/remitting condition characterised by intestinal inflammation. One of the main concerns in patients with longstanding ulcerative and Crohn's colitis is development of colonic dysplasia and colorectal cancer (CRC), a risk higher than that of the general population. Colonoscopy surveillance programmes have been developed by major societies worldwide to improve early dysplasia detection and treatment, thus preventing progression to colorectal cancer...
October 2016: Frontline Gastroenterology
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