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Zhen-Zhong Zheng, Zhiming Tu, Yawei Li, Yuliang Dai, Peng-Fei Wu, Bing Jiang, Jietao Xu, Shipeng Xiao, Lei Li, Guo-Hua Lv, Bing Wang
OBJECTIVE: This retrospective study attempted to evaluate the clinical results of full-endoscopic lumbar discectomy (FELD) for the treatment of lumbar disc herniation (LDH) with lumbar posterior ring apophysis fracture (PRAF) via the interlaminar (IL) or transforaminal(TF) approach. STUDY DESIGN: Retrospective study. SETTING: Inpatient surgery center METHODS: A series of single-level LDH with Type III PRAF patients who underwent FELD via an IL or TF approach between January 2010 and December 2015 was enrolled...
December 24, 2018: World Neurosurgery
Rahul Garg, Pankaj Dixit, Taruna Khosla, Palak Gupta, Hiten Kalra, Prafful Kumar
AIM: To compare effects of three different burs, i.e., tungsten carbide bur, composite bur, and fiber glass bur on the surface roughness of enamel after debonding evaluated by means of profilometry. MATERIALS AND METHODS: The present study was conducted in the Department of Orthodontics and Dentofacial Orthopedics, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India, from August 2011 to December 2012 on 36 extracted premolars. After mounting the samples in acrylic blocks with their buccal surfaces exposed, initial measurement of the surface roughness was made using profilometry...
May 1, 2018: Journal of Contemporary Dental Practice
T V Sukhacheva, V A Vaskovsky, A Sh Revishvili, R A Serov
AIM: to analyze the morphological features of the myocardium of the atrial appendages in patients with different forms of atrial fibrillation (AF) and to compare the findings with the clinical parameters of patients. MATERIAL AND METHODS: Light and electron microscopies were used to examine the myocardium of the atrial appendages in adult patients with paroxysmal (PAF), persistent (PrAF), or long-standing persistent atrial fibrillation (LPAF) and in comparison group patients with sinus rhythm without history of AF...
2017: Arkhiv Patologii
Narendra Parkash Rai, Prafful Kumar, Shabil M Mustafa, Darshan D Divakar, Abdulaziz Al Kheraif, Ravikumar Ramakrishnaiah, Sajith Vellapally, M H N Dalati, Narashimha Reddy Parine, Sukumaran Anil
BACKGROUND: Oral lichen planus (OLP) is a common chronic mucocutaneous disease mostly seen in middle aged and elderly females. Oral lichen planus can occur in different oral sites such as gingiva, labial, buccal mucosa and on the tongue. And can have an indirect effect on initiating periodontitis. OBJECTIVES: The purpose of the study was to evaluate the periodontal status of OLP patients and compare it with that of healthy controls. The presence of erosive lesions among gingival tissues makes oral hygiene procedures difficult to perform for obvious reasons...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Trevor Deleo, Samuel Merotto, Colyn Smith, Kevin D'Angelo
OBJECTIVE: To describe the diagnosis and management of a competitive male basketball player with discogenic low back pain and presence of an old posterior ring apophyseal fracture (PRAF). This case will highlight the importance of early recognition and considerations regarding patient management for this differential of radiating low back pain. CLINICAL FEATURES: A 21-year-old provincial basketball player presented with recurrent radiating low back pain into the left groin and lower limb...
December 2015: Journal of the Canadian Chiropractic Association
Priya Nagar, Yogesh L Tandil, Chandru T P, Anamika Gupta, Devendra Kalaria, Prafful Kumar
BACKGROUND: Over the years, it has been known that 34% phosphoric acid is the benchmark in etchants with the best shear bond strength shown with composites in primary teeth. However, with latest technological advancements and innovations, in order to reduce the number of steps and less damage to the tooth structure, non-rinse conditioner (NRC) & Single-Etch and various other etchants have been tried and tested. These etchants have been found to have shear bond strength comparable to phosphoric acid...
August 2015: Journal of International Oral Health: JIOH
Ravi Kumar T V, Raghavendra Rao, Daksh Gadi, Amit Grover
Posterior apophyseal ring fracture is a rare condition typically seen in adolescent age group because the ring apophysis and the adjacent vertebral body does not fuse completely and may separate at the cephalad or caudal edge. It usually simulates disc herniation in adolescents and children but disc lesion is very commonly associated with PRAF. The condition although is rare but a high index of suspicion should be there during evaluation of any adolescent patient with low back ache as it is often missed on conventional radiography...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
George Galea, Mariana G Bexiga, Angela Panarella, Elaine D O'Neill, Jeremy C Simpson
Here, we describe a high-content microscopy-based screen that allowed us to systematically assess and rank proteins involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport in mammalian cells. Using a cell line stably expressing a GFP-tagged Golgi enzyme, we used brefeldin A treatment to stimulate the production of Golgi-to-ER carriers and then quantitatively analysed populations of cells for changes in this trafficking event. Systematic RNA interference (RNAi)-based depletion of 58 Rab GTPase proteins and 12 Rab accessory proteins of the PRAF, YIPF and YIF protein families revealed that nine of these were strong regulators...
July 1, 2015: Journal of Cell Science
Ameya D Puranik, Nilendu C Purandare, Sheela Sawant, Archi Agrawal, Sneha Shah, Prafful Jatale, Venkatesh Rangarajan
Metastatic involvement of the heart is a rare occurrence and remains undiagnosed until autopsy. In some instances, patients may have cardiac symptoms, leading to ante-mortem diagnosis. Although most primary cancers have been documented to metastasize to heart, the existing literature on cancers of upper aero-digestive tract is an exception, with only a few reports. We report four cases of upper aero-digestive tract cancers, three of which arise from oral cavity, one from lower esophagus, metastasising to the myocardium, detected on 18 F - Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) study , in the absence of related symptoms...
April 28, 2014: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Harish M C Saluja, Bhimmapa Mallapa Rudagi, Uma Rajan Mahindra, Prafful T Gaikwad, Vipin V Dehane
Though reported cases of foreign bodies left intraoperatively in the oral cavity are very few, there is no case mentioned in the literature where foreign body was left behind during follow-up visits. Here, we present an operated case of unicystic ameloblastoma of mandibular ramus region, in which a needle hub was left at the operated site (cavity created because of wound dehiscence) during some of the follow-up visits, which was detected accidently by radiograph and later on retrieved. The case reported was because of negligence of trainee surgeons, might be because of overburden or because of minimal interest in these repeated follow ups...
January 2014: National Journal of Maxillofacial Surgery
Rangadham Nagarakanti, April Slee, Sanjeev Saksena
INTRODUCTION: Dual-site right atrial pacing (DAP) produces electrical atrial resynchronization but its long-term effect on the atrial mechanical function in patients with refractory atrial fibrillation (AF) has not been studied. METHODS: Drug-refractory paroxysmal (PAF) and persistent AF (PRAF) patients previously implanted with a dual-site right atrial pacemaker (DAP) with minimal ventricular pacing modes (AAIR or DDDR mode with long AV delay) were studied. Echocardiographic structural (left atrial diameter [LAD] and left ventricular [LV] end diastolic diameter [EDD], end systolic diameter [ESD]) and functional (ejection fraction [EF]) parameters were serially assessed prior to, after medium-term (n = 39) and long-term (n = 34) exposure to DAP...
September 2014: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Chin Yi Cheng, Jaung Geng Lin, Shan Yu Su, Nou Ying Tang, Shung Te Kao, Ching Liang Hsieh
BACKGROUND: This study was designed to evaluate the effects of electroacupuncture-like stimulation at Baihui (GV20) and Dazhui (GV14) acupoints (EA at acupoints) following mild cerebral ischemia-reperfusion (I/R) injury. Furthermore, we investigated whether brain-derived neurotrophic factor (BDNF)-mediated activation of extracellular signal-regulated kinase (ERK)1/2 signaling pathway is involved in the neuroprotection induced by EA at acupoints. METHODS: Rats were subjected to middle cerebral artery occlusion (MCAo) for 15 min followed by reperfusion for 3 d...
2014: BMC Complementary and Alternative Medicine
Harish Saluja, Vipin Dehane, Yogesh Kini, Uma Mahindra, Prafful Gaikwad
Aim of the study was to find out the number of miniplates used by Indian Oral and Maxillofacial Surgeons for parasymphysis fractures. A survey was done among Oral and Maxillofacial Surgeons of India at the 34th annual meeting of Association of Oral and Maxillofacial Surgeons of India. Four questions were given to each individual to find out their opinion regarding use of miniplates in parasymphysis fractures. Eighty-eight per cent of Indian surgeons were in favour of using intra-operative or post-operative intermaxillary fixation...
September 2013: Journal of Maxillofacial and Oral Surgery
Julie Hopkins, Olivier Pierre, Théophile Kazmierczak, Véronique Gruber, Florian Frugier, Mathilde Clement, Pierre Frendo, Didier Herouart, Eric Boncompagni
PRAF proteins are present in all plants, but their functions remain unclear. We investigated the role of one member of the PRAF family, MtZR1, on the development of roots and nitrogen-fixing nodules in Medicago truncatula. We found that MtZR1 was expressed in all M. truncatula organs. Spatiotemporal analysis showed that MtZR1 expression in M. truncatula roots was mostly limited to the root meristem and the vascular bundles of mature nodules. MtZR1 expression in root nodules was down-regulated in response to various abiotic stresses known to affect nitrogen fixation efficiency...
March 2014: Plant, Cell & Environment
Lisette P Yco, Dirk Geerts, Jan Koster, André S Bachmann
Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is a novel 19-kDa protein with four transmembrane-spanning domains that belongs to the PRAF protein family. Neuroblastoma (NB) is the most common malignant extracranial solid tumor of childhood that originates in primitive cells of the developing sympathetic nervous system. We investigated the correlation of PRAF2 mRNA expression to NB clinical and genetic parameters using Affymetrix expression analysis of a series of 88 NB tumors and examined the functional role of PRAF2 in an NB cell line using RNA interference...
April 2013: International Journal of Oncology
J Lindahl, L Handolin, T Söderlund, M Porras, E Hirvensalo
PURPOSE: The control of arterial bleeding associated with pelvic ring and acetabular fractures (PRAF) remains a challenge for emergency trauma care. The aim of the present study was to uncover early prognostic mortality-related factors in PRAF-related arterial bleedings treated with transcatheter angiographic embolization (TAE). METHODS: Forty-nine PRAF patients (46 pelvic ring and three acetabular fractures) with arterial pelvic bleeding controlled with TAE (within 24 h) were evaluated...
February 2013: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Xueyuan Wu, Wei Ma, Heng Du, Kiran Gurung
PURPOSE: Lumbar posterior ring apophysis fracture (PRAF) is an uncommon disorder frequently accompanied by lumbar disc herniation (LDH). Over the years, there have constantly been published studies concerning this disorder. Due to its rarity, there is lack of an agreed treatment strategy, and lots of different opinions exist, including the choice of decompressive modalities, whether removal of apophyseal fragments or/and disc material, and the necessity of additional spinal fusion. The purpose of this review is to provide a collective opinion on the treatment of PRAF with LDH...
March 2013: European Spine Journal
Cem Ozel, Jeanette Seidel, Sönke Meyer-Staeckling, Burkhard H Brandt, Bernd Niggemann, Kurt S Zänker, Thomas Dittmar
BACKGROUND: The biological phenomenon of cell fusion has been linked to several characteristics of tumour progression, including an enhanced metastatogenic capacity and an enhanced drug resistance of hybrid cells. We demonstrated recently that M13SV1-EGFP-Neo breast epithelial cells exhibiting stem cell characteristics spontaneously fused with MDA-MB-435-Hyg breast cancer cells, thereby giving rise to stable M13MDA435 hybrid cells, which are characterised by a unique gene expression profile and migratory behaviour...
2012: Cell Communication and Signaling: CCS
Lauy Al-Anati, Ebtisam Essid, Ulla Stenius, Knut Beuerlein, Klaus Schuh, Ernst Petzinger
The release of tumor necrosis factor α (TNF-α) by ochratoxin A (OTA) was studied in various macrophage and non-macrophage cell lines and compared with E. coli lipopolysaccharide (LPS) as a standard TNF-α release agent. Cells were exposed either to 0, 2.5 or 12.5 µmol/L OTA, or to 0.1 µg/mL LPS, for up to 24 h. OTA at 2.5 µmol/L and LPS at 0.1 µg/mL were not toxic to the tested cells as indicated by viability markers. TNF-α was detected in the incubated cell medium of rat Kupffer cells, peritoneal rat macrophages, and the mouse monocyte macrophage cell line J774A...
June 2010: Toxins
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