Hynek Mergental, Richard W Laing, Amanda J Kirkham, George Clarke, Yuri L Boteon, Darren Barton, Desley A H Neil, John R Isaac, Keith J Roberts, Manuel Abradelo, Andrea Schlegel, Bobby V M Dasari, James W Ferguson, Hentie Cilliers, Chris Morris, Peter J Friend, Christina Yap, Simon C Afford, M Thamara P R Perera, Darius F Mirza
Normothermic machine perfusion (NMP) enables pretransplant assessment of high-risk donor livers. The VITTAL trial demonstrated that 71% of the currently discarded organs could be transplanted with 100% 90-day patient and graft survivals. Here, we report secondary end points and 5-year outcomes of this prospective, open-label, phase 2 adaptive single-arm study. The patient and graft survivals at 60 months were 82% and 72%, respectively. Four patients lost their graft due to nonanastomotic biliary strictures, one caused by hepatic artery thrombosis in a liver donated following brain death, and 3 in elderly livers donated after circulatory death (DCD), which all clinically manifested within 6 months after transplantation...
January 1, 2024: Liver Transplantation