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Hepatitis c and organ donor

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https://read.qxmd.com/read/30773693/renal-transplantation-from-seropositive-hepatitis-c-virus-donors-to-seronegative-recipients-in-spain-a-prospective-study
#1
A Franco, F Moreso, E Merino, A Sancho, J Kanter, A Gimeno, N Balibrea, M Rodriguez, J Perez Contreras
BACKGROUND: Hepatitis C virus (HCV) positive donors are identified in Spain by antibody detection (HCV-Ab) techniques while and HCV nuclear acid-testing (HCV-NAT) is not mandatory. Since it has been shown that HCV-Ab positive HCV-NAT negative donors do not universally transmit the infection, we designed a protocol based on the identification of viremia in HCV-Ab positive donors to start treatment if needed. METHODS: HCV-Ab-positive donors were identified and we performed...
February 17, 2019: Transplant International: Official Journal of the European Society for Organ Transplantation
https://read.qxmd.com/read/30773688/solid-organ-transplantation-in-the-hiv-infected-patient-guidelines-from-the-american-society-of-transplantation-infectious-diseases-community-of-practice
#2
Emily A Blumberg, Christin C Rogers
These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the management of transplantation in HIV infected individuals. Transplantation has become the standard of care for patients with HIV and end stage kidney or liver disease. Although less data exist for thoracic organ and pancreas transplantation, it is likely that transplantation is also safe and effective for these recipients as well. Despite what is typically a transient decline in CD4+ T lymphocytes, HIV remains well-controlled and infection risks are similar to those of HIV uninfected transplant recipients...
February 17, 2019: Clinical Transplantation
https://read.qxmd.com/read/30768838/transplanting-hepatitis-c-virus-infected-hearts-into-uninfected-recipients-a-single-arm-trial
#3
Rhondalyn C McLean, Peter P Reese, Michael Acker, Pavan Atluri, Christian Bermudez, Lee Goldberg, Peter L Abt, Emily A Blumberg, Vivianna M Van Deerlin, K Rajender Reddy, Roy D Bloom, Richard Hasz, Lawrence Suplee, Anna Sicilia, Ashley Woodards, Muhammad Nauman Zahid, Katharine J Bar, Paige Porrett, Matthew Levine, Nicole Hornsby, Caren Gentile, Jennifer Smith, David S Goldberg
The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated tremendous interest in transplanting organs from HCV-infected donors. We conducted a single-arm trial of orthotopic heart transplantation (OHT) from HCV-infected donors into uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first detected (NCT03146741; sponsor: Merck). We enrolled OHT candidates aged 40-65 years; LVAD support and liver disease were exclusions. We accepted hearts from HCV-genotype 1 donors...
February 15, 2019: American Journal of Transplantation
https://read.qxmd.com/read/30741534/non-invasive-tracking-and-regenerative-capabilities-of-transplanted-human-umbilical-cord-derived-mesenchymal-stem-cells-labeled-with-i-iii-iv-semiconducting-nanocrystals-in-liver-injured-living-mice
#4
Shashank Shankar Chetty, Selvarasu Praneetha, Kavitha Govarthanan, Rama Shanker Verma, Arumugam Vadivel Murugan
Acute liver injury is a critical syndrome ascribed to prevalent death of hepatocyte and imperatively requires a liver transplantation. Such methodology is certainly hampered due to deficit of healthy donors. In this regard, stem cells-based regenerative therapies are attractive in repairing injured tissues and organs for medical applications. However, it is crucial to understand the migration, engraftment and regeneration capabilities of transplanted stem cells in the living animal models. For the first time, we demonstrate rapid labeling of umbilical cord-derived mesenchymal stem cells (MSCs) with near-infrared (NIR) fluorescent CuInS2-ZnS nanocrystals (CIZS-NCs) to develop an innovative nano-bioconjugates (MSCs-CIZS-NBCs) that exhibit 98% labeling efficiency...
February 11, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30716208/improved-graft-survival-after-liver-transplantation-for-recipients-with-hepatitis-c-in-the-direct-acting-antiviral-era
#5
Thomas G Cotter, Sonali Paul, Burhaneddin Sandıkçı, Thomas Couri, Adam S Bodzin, Ester C Little, Vinay Sundaram, Michael Charlton
BACKGROUND: Highly effective direct acting antiviral (DAA) therapy has transformed outcomes of liver transplantation in HCV patients. We examined longer-term outcomes in HCV-positive recipients in the DAA era. METHODS: We analyzed the Scientific Registry of Transplant Recipients (SRTR) for primary adult, single organ, non-fulminant liver transplant recipients in the US from January 1, 2008, to June 30, 2018. Graft loss was compared among HCV-positive liver transplant recipients that received an HCV-negative and -positive donors (D-/R+) (D+/R+) and HCV-negative liver transplant recipients that received an HCV-negative donor (D-/R-)...
February 4, 2019: Liver Transplantation
https://read.qxmd.com/read/30706517/increasing-utilization-and-excellent-initial-outcomes-following-liver-transplant-of-hcv-viremic-donors-into-hcv-negative-recipients
#6
Thomas G Cotter, Sonali Paul, Burhaneddin Sandıkçı, Thomas Couri, Adam S Bodzin, Ester C Little, Vinay Sundaram, Michael Charlton
BACKGROUND & AIMS: Direct-acting antiviral (DAA) therapy has altered the frequency and outcome of liver transplantation for hepatitis C virus (HCV). The high efficacy and tolerability of DAA therapy has also created a rationale for utilizing HCV-viremic (HCV-RNA-positive) donors, including into HCV-negative recipients. We examined trends in the frequency of organ utilization and graft survival in recipients of HCV-viremic donors (HCV-RNA-positive as measured by Nucleic Acid Testing, NAT)...
January 31, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30704882/mortality-and-kidney-transplantation-outcomes-among-hepatitis-c-virus-seropositive-maintenance-dialysis-patients-a-retrospective-cohort-study
#7
Deirdre Sawinski, Kimberly A Forde, Vincent Lo Re, David S Goldberg, Jordana B Cohen, Jayme E Locke, Roy D Bloom, Colleen Brensinger, Joe Weldon, Justine Shults, Peter P Reese
RATIONALE & OBJECTIVE: Hepatitis C virus (HCV) infection is common among maintenance dialysis patients. Few studies have examined both dialysis survival and transplantation outcomes for HCV-seropositive patients because registry data sets lack information for HCV serostatus. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adult long-term dialysis patients treated by a US national dialysis provider between January 1, 2004, and December 31, 2014...
January 29, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://read.qxmd.com/read/30696822/inactivating-hepatitis-c-virus-in-donor-lungs-using-light-therapies-during-normothermic-ex-vivo-lung-perfusion
#8
Marcos Galasso, Jordan J Feld, Yui Watanabe, Mauricio Pipkin, Cara Summers, Aadil Ali, Robert Qaqish, Manyin Chen, Rafaela V P Ribeiro, Khaled Ramadan, Layla Pires, Vanderlei S Bagnato, Cristina Kurachi, Vera Cherepanov, Gray Moonen, Anajara Gazzalle, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee, Brian C Wilson, Atul Humar, Marcelo Cypel
Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time...
January 29, 2019: Nature Communications
https://read.qxmd.com/read/30693636/infections-and-associated-behaviours-among-deceased-organ-donors-informing-the-assessment-of-risk
#9
Katy L Davison, Ines Ushiro-Lumb, Marcus Lawrance, Patrick Trotter, James J Powell, Susan R Brailsford
BACKGROUND: For infectious disease risk assessment among deceased organ donors, pre-donation clinical, microbiological and behavioural information are reviewed, however, uncertainty may arise due to false negative screening results of recently acquired infections. METHOD: The burden of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), and residual risks (RR) of undetected virus was estimated, with the impact of more sensitive screening...
January 29, 2019: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30677008/characteristics-of-deceased-solid-organ-donors-and-screening-results-for-hepatitis-b-c-and-human-immunodeficiency-viruses-united-states-2010-2017
#10
Winston E Abara, Melissa G Collier, Anne Moorman, Danae Bixler, Jefferson Jones, Pallavi Annambhotla, James Bowman, Marilyn E Levi, John T Brooks, Sridhar V Basavaraju
The ongoing U.S. opioid crisis has resulted in an increase in drug overdose deaths and acute hepatitis C virus (HCV) infections, with young persons (who might be eligible organ donors) most affected.*, † In 2013, the Public Health Service released a revised guideline to reduce the risk for unintended organ transplantation-associated hepatitis B virus (HBV), HCV, and human immunodeficiency virus (HIV) transmission (1). The guideline describes criteria to categorize donors at increased risk (increased risk donors [IRDs]) for transmitting these viruses to recipients (1)...
January 25, 2019: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/30656214/infectious-disease-transmission-in-solid-organ-transplantation-donor-evaluation-recipient-risk-and-outcomes-of-transmission
#11
Sarah L White, William Rawlinson, Peter Boan, Vicky Sheppeard, Germaine Wong, Karen Waller, Helen Opdam, John Kaldor, Michael Fink, Deborah Verran, Angela Webster, Kate Wyburn, Lindsay Grayson, Allan Glanville, Nick Cross, Ashley Irish, Toby Coates, Anthony Griffin, Greg Snell, Stephen I Alexander, Scott Campbell, Steven Chadban, Peter Macdonald, Paul Manley, Eva Mehakovic, Vidya Ramachandran, Alicia Mitchell, Michael Ison
In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management...
January 2019: Transplantation Direct
https://read.qxmd.com/read/30614634/survival-benefit-of-accepting-livers-from-deceased-donors-over-70-years-old
#12
Christine E Haugen, Mary G Bowring, Courtenay M Holscher, Kyle R Jackson, Jacqueline Garonzik-Wang, Andrew M Cameron, Benjamin Philosophe, Mara McAdams-DeMarco, Dorry L Segev
Livers from older donors (OLD; age≥70) are risky and often declined; however, it is likely that some candidates will benefit from OLDs versus waiting for younger ones. To characterize the survival benefit of accepting OLD grafts, we used 2009-2017 SRTR data to identify 24,431 adult liver transplant (LT) candidates who were offered OLD grafts eventually accepted by someone. Outcomes from the time-of-offer were compared between candidates who accepted an OLD graft and matched controls within MELD±2 who declined the same offer...
January 7, 2019: American Journal of Transplantation
https://read.qxmd.com/read/30599173/in-vivo-combination-of-human-anti-envelope-glycoprotein-e2-and-claudin-1-monoclonal-antibodies-for-prevention-of-hepatitis-c-virus-infection
#13
Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B Zeisel, Patrick Pessaux, Zhen-Yong Keck, Catherine Schuster, Thomas R Fuerst, Steven K H Foung, Thomas F Baumert
Despite the development of direct-acting antivirals (DAAs), hepatitis C virus (HCV) infection remains a major cause for liver disease and cancer worldwide. Entry inhibitors block virus host cell entry and, therefore, prevent establishment of chronic infection and liver disease. Due to their unique mechanism of action, entry inhibitors provide an attractive antiviral strategy in organ transplantation. In this study, we developed an innovative approach in preventing HCV infection using a synergistic combination of a broadly neutralizing human monoclonal antibody (HMAb) targeting the HCV E2 protein and a host-targeting anti-claudin 1 (CLDN1) humanized monoclonal antibody...
December 29, 2018: Antiviral Research
https://read.qxmd.com/read/30590666/clinical-vignettes-donor-derived-infections
#14
Tanvi S Sharma, Marian G Michaels, Lara Danziger-Isakov, Betsy C Herold
Patients undergoing solid organ transplantation (SOT) may acquire infections from the transplanted organ. Routine screening for common infections are an established part of the pretransplant evaluation of donors and recipients. Likewise, strategies exist for prophylaxis and surveillance for common donorassociated infections including hepatitis B, CMV and EBV. However, despite advances in diagnostic testing to evaluate the infectious risk of donors, unanticipated transmission of pathogens occurs, particularly when donors are asymptomatic or have subtle or unusual manifestations of a transmissible Infection...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590657/clinical-vignettes-donor-derived-infections
#15
Tanvi S Sharma, Marian G Michaels, Lara Danziger-Isakov, Betsy C Herold
Patients undergoing solid organ transplantation (SOT) may acquire infections from the transplanted organ. Routine screening for common infections are an established part of the pretransplant evaluation of donors and recipients. Likewise, strategies exist for prophylaxis and surveillance for common donorassociated infections including hepatitis B, CMV and EBV. However, despite advances in diagnostic testing to evaluate the infectious risk of donors, unanticipated transmission of pathogens occurs, particularly when donors are asymptomatic or have subtle or unusual manifestations of a transmissible Infection...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590644/clinical-vignettes-donor-derived-infections
#16
Tanvi S Sharma, Marian G Michaels, Lara Danziger-Isakov, Betsy C Herold
Patients undergoing solid organ transplantation (SOT) may acquire infections from the transplanted organ. Routine screening for common infections are an established part of the pretransplant evaluation of donors and recipients. Likewise, strategies exist for prophylaxis and surveillance for common donorassociated infections including hepatitis B, CMV and EBV. However, despite advances in diagnostic testing to evaluate the infectious risk of donors, unanticipated transmission of pathogens occurs, particularly when donors are asymptomatic or have subtle or unusual manifestations of a transmissible Infection...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590635/clinical-vignettes-donor-derived-infections
#17
Tanvi S Sharma, Marian G Michaels, Lara Danziger-Isakov, Betsy C Herold
Patients undergoing solid organ transplantation (SOT) may acquire infections from the transplanted organ. Routine screening for common infections are an established part of the pretransplant evaluation of donors and recipients. Likewise, strategies exist for prophylaxis and surveillance for common donorassociated infections including hepatitis B, CMV and EBV. However, despite advances in diagnostic testing to evaluate the infectious risk of donors, unanticipated transmission of pathogens occurs, particularly when donors are asymptomatic or have subtle or unusual manifestations of a transmissible Infection...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30590624/clinical-vignettes-donor-derived-infections
#18
Tanvi S Sharma, Marian G Michaels, Lara Danziger-Isakov, Betsy C Herold
Patients undergoing solid organ transplantation (SOT) may acquire infections from the transplanted organ. Routine screening for common infections are an established part of the pretransplant evaluation of donors and recipients. Likewise, strategies exist for prophylaxis and surveillance for common donorassociated infections including hepatitis B, CMV and EBV. However, despite advances in diagnostic testing to evaluate the infectious risk of donors, unanticipated transmission of pathogens occurs, particularly when donors are asymptomatic or have subtle or unusual manifestations of a transmissible Infection...
December 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/30586641/use-of-hepatitis-c-ab-positive-donor-liver-in-hepatitis-c-nonviremic-liver-transplant-recipients
#19
Keith Luckett, Tiffany Kaiser, Khurram Bari, Kamran Safdar, Michael R Schoech, Senu Apewokin, Tayyab Diwan, Madison C Cuffy, Nadeem Anwar, Shimul A Shah
INTRO: Given the shortage of available liver grafts, transplantation (LTx) of Hepatitis C antibody positive, nucleic acid test negative (HCV Ab+/NAT-) livers into non-viremic HCV recipients may expand the donor pool. Having previously described the sentinel experience of HCV Ab+/NAT- allografts in non-viremic recipients, we report the growth and extended follow-up of this program for 55 patients compared to recipients of PHS increased risk donor (IRD) HCV Ab-/NAT- allografts. STUDY DESIGN: A prospective review of all HCV non-viremic LTx recipients transplanted with an HCV Ab+/NAT- organs between 3/2016 and 8/2018 was performed...
December 23, 2018: Journal of the American College of Surgeons
https://read.qxmd.com/read/30577239/liver-transplant-waitlist-outcomes-and-the-allocation-of-hepatocellular-carcinoma-model-for-end-stage-liver-disease-exception-points-at-a-low-volume-center
#20
E K Tan, B K P Goh, S Y Lee, T L Krishnamoorthy, C K Tan, P R Jeyaraj
BACKGROUND: Organ scarcity continues to be the main problem limiting the number of liver transplants performed. Outcomes of patients waitlisted for an organ in an Asian country with low organ donation rate have not been well evaluated. Our current policy of allocating 15 exception points to patients with hepatocellular carcinoma (HCC) to render them competitive for a transplant also requires review. METHODS: The waiting list registry and the organ transplant registry of a single institution in Asia were reviewed from December 2005 to June 2016 for all patients who underwent liver transplantation...
December 2018: Transplantation Proceedings
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