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JOURNAL ARTICLE
Sydney Timmer-Murillo, Andrew T Schramm, Timothy J Geier, Emilie Mcleod, Christine L Larson, Terri A deRoon-Cassini
Background: Emotion dysregulation is a hallmark characteristic of psychopathology following trauma. Yet, emotion dysregulation is multifaceted, and little is known about which aspects of emotion dysregulation predict depression and posttraumatic stress disorder (PTSD) symptom severity following traumatic injury. Objective: The aim of this longitudinal study was to evaluate how facets of dysregulation differentially predicted the severity of PTSD symptom clusters and depressive symptoms six months after a traumatic injury requiring medical treatment...
2023: European Journal of Psychotraumatology
#42
REVIEW
Marco Cavicchioli, Anna Ogliari, Cesare Maffei, Clara Mucci, Georg Northoff, Andrea Scalabrini
AIM: Departing from existing neurobiological models of dissociation, the current study aims at conducting a quantitative meta-analytic review of neural responses to emotional stimuli among individuals ascribed to the dissociative spectrum (DS). Accordingly, the study explored common and specific brain mechanisms across borderline personality disorder, conversion/somatoform disorders, posttraumatic stress disorder, posttraumatic stress disorder related to repeated interpersonal traumatic experiences, and dissociative disorders...
June 2023: Psychiatry and Clinical Neurosciences
#43
JOURNAL ARTICLE
Knockdown of adenosine A2A receptors in hippocampal neurons prevents post-TBI fear memory retrieval.
Xiao-Qing Cen, Ping Li, Bo Wang, Xing Chen, Yan Zhao, Nan Yang, Yan Peng, Chang-Hong Li, Ya-Lei Ning, Yuan-Guo Zhou
The formation of fear memory is crucial in emotional disorders such as PTSD and anxiety. Traumatic brain injury (TBI) can cause emotional disorders with dysregulated fear memory formation; however, their cross-interaction remains unclear and hurdled the treatment against TBI-related emotional disorders. While adenosine A2A receptor(A2AR) contributes to the physiological regulation of fear memory, this study aimed to evaluate the A2AR role and possible mechanisms in post-TBI fear memory formation using a craniocerebral trauma model, genetically modified A2AR mutant mice, and pharmacological A2AR agonist CGS21680 and antagonist ZM241385...
March 11, 2023: Experimental Neurology
#44
JOURNAL ARTICLE
Graham Gee, Carol Hulbert, Helen Kennedy, Yin Paradies
In addition to resilience and resistance, collective and personal experiences of trauma are commonly cited within the context of Aboriginal and Torres Strait Islander and other Indigenous First People's experiences of colonisation. This study investigated whether a range of risk and protective factors, including cultural determinants of social and emotional wellbeing, were associated with posttraumatic stress outcomes among 81 Aboriginal help-seeking clients from an Aboriginal community-controlled counselling service in Melbourne, Australia...
March 10, 2023: BMC Psychiatry
#45
REVIEW
Cassandra G Modrak, Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knackstedt
Stress and trauma exposure contribute to the development of psychiatric disorders such as post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) in a subset of people. A large body of preclinical work has found that the metabotropic glutamate (mGlu) family of G protein-coupled receptors regulate several behaviors that are part of the symptom clusters for both PTSD and MDD, including anhedonia, anxiety, and fear. Here, we review this literature, beginning with a summary of the wide variety of preclinical models used to assess these behaviors...
2023: International Review of Neurobiology
#46
JOURNAL ARTICLE
Steffany J Fredman, Melanie S Fischer, Donald H Baucom, Yunying Le, Emily C Taverna, Sy-Miin Chow, Nilam Ram, Amy D Marshall
This study investigated the associations between momentary emotion dynamics and posttraumatic stress disorder (PTSD) symptoms. Using a sample of 61 couples (N = 122 individuals) in which all individuals were trauma exposed and at least one partner screened positive for PTSD, we examined the intra- and interpersonal regulation of vocally encoded emotional arousal (fundamental frequency [f0 ]) and how these momentary emotion regulatory patterns relate to specific PTSD symptoms during two couple conversations: one designed to elicit conflict and one to elicit intimacy...
March 2023: Behavior Therapy
#47
REVIEW
Sedigh Khademi, Christine Mary Hallinan, Mike Conway, Yvonne Bonomo
BACKGROUND: The use and acceptance of medicinal cannabis is on the rise across the globe. To support the interests of public health, evidence relating to its use, effects, and safety is required to match this community demand. Web-based user-generated data are often used by researchers and public health organizations for the investigation of consumer perceptions, market forces, population behaviors, and for pharmacoepidemiology. OBJECTIVE: In this review, we aimed to summarize the findings of studies that have used user-generated text as a data source to study medicinal cannabis or the use of cannabis as medicine...
February 27, 2023: Journal of Medical Internet Research
#48
JOURNAL ARTICLE
Association between traumatic life events and vaccine hesitancy: A cross-sectional Australian study.
Maria Christou-Ergos, Kerrie E Wiley, Julie Leask
OBJECTIVES: We sought to identify associations between the experience of traumatic life events and vaccination intention to inform whether trauma-affected individuals require targeted interventions when addressing vaccine hesitancy. STUDY DESIGN: We conducted an online cross-sectional survey to identify whether direct or indirect exposure to various traumatic life events and the presence of post-traumatic stress disorder (PTSD) symptoms are associated with willingness to receive a COVID-19 vaccine in an Australian sample...
January 18, 2023: Public Health
#49
REVIEW
Hagit Cohen, Olusola T Ephraim-Oluwanuga, Orunmuyi T Akintunde, Oye Gureje, Michael A Matar, Doron Todder, Joseph Zohar
Sleep figures in numerous ancient texts, for example, Epic of Gilgamesh, and has been a focus for countless mystical and philosophical texts. Even in the present century, sleep remains one of the most complex behaviors whose function still remains to be further explored. Current hypotheses suggest that among other functions, sleep contributes to memory processes. Memory is a core topic of study in post-traumatic stress disorder (PTSD) and other stress-related phenomena. It is widely accepted that sleep plays a major role in the consolidation of newly encoded hippocampus-dependent memories to pre-existing knowledge networks...
January 9, 2023: Neuropsychopharmacology Reports
#50
JOURNAL ARTICLE
Alison Pellecchia, Minos Kritikos, Jack Guralnik, Isaac Ahuvia, Stephanie Santiago-Michels, Melissa Carr, Roman Kotov, Evelyn J Bromet, Sean A P Clouston, Benjamin J Luft
BACKGROUND AND OBJECTIVES: Posttraumatic stress disorder (PTSD) has been linked to increased risk of cognitive dysfunction and physical functional impairment (PFI). The objective of this prospective cohort study was to examine whether PFI was associated with increased risk of incident mild cognitive impairment (MCI) among World Trade Center (WTC) responders with PTSD. We hypothesized that responders with PTSD would have an elevated risk of incident MCI and that PFI would mediate this increase...
December 2022: Neurology. Clinical Practice
#51
JOURNAL ARTICLE
Phyu Pannu Khin, Keith Burt, Karen Fondacaro
INTRODUCTION: There are 1.3 million refugee survivors of torture living in the United States today. An existing body of research with refugees has largely examined mental health, but few of these studies focused on resilience. OBJECTIVE: Using a clinical sample of refugee survivors of torture, we tested the resiliencepromoting factors of community engagement, employment, English fluency, and psychological flexibility. We conducted moderation and mediation analyses to investigate how these resilience-promoting factors impact the torture-mental health relationship...
2022: Torture: Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture
#52
JOURNAL ARTICLE
Sara Paredes-Echeverri, Andrew J Guthrie, David L Perez
BACKGROUND: As a group, individuals with functional neurological disorder (FND) report an approximately 3-fold increase in adverse life experiences (ALEs) compared to healthy controls. In patients with FND, studies have identified a positive correlation between symptom severity and the magnitude of ALEs. While not all individuals with FND report ALEs, such findings raise the possibility of a trauma-subtype of FND. OBJECTIVE: This study investigated if patients with FND, with or without probable post-traumatic stress disorder (PTSD) and/or significant childhood maltreatment, differed in their symptom severity and physical health...
2022: Frontiers in Psychiatry
#53
JOURNAL ARTICLE
Samuele Laudani, Sebastiano A Torrisi, Silvia Alboni, Thomaz F S Bastiaanssen, Cristina Benatti, Veronica Rivi, Rachel D Moloney, Virginia Fuochi, Pio M Furneri, Filippo Drago, Salvatore Salomone, Fabio Tascedda, John F Cryan, Gian Marco Leggio
Mounting evidence suggests a link between gut microbiota abnormalities and post-traumatic stress disorder (PTSD). However, whether and how the gut microbiota influences PTSD susceptibility is poorly understood. Here using the arousal-based individual screening model we provide evidence for pre-trauma and post-trauma gut microbiota alterations in susceptible mice exhibiting persistent PTSD-related phenotypes. A more in-depth analysis revealed an increased abundance of bacteria affecting brain processes including myelination, and brain systems like the dopaminergic system...
November 15, 2022: Brain, Behavior, and Immunity
#54
JOURNAL ARTICLE
Demelza Smeeth, Fiona S McEwen, Cassandra M Popham, Elie G Karam, John Fayyad, Dahlia Saab, Michael J Rieder, Abdelbaset A Elzagallaai, Stan van Uum, Michael Pluess
Altered secretion of cortisol, the primary effector of the hypothalamus-pituitary-adrenal axis, has been proposed as a means by which traumatic experiences compromise later mental health. However, despite the popularity of cortisol as a potential biomarker for stress and adversity, findings are inconsistent, and little is known about the impact of war-related trauma on stress physiology of children and adolescents. Here we aimed to evaluate the relationships between war exposure, current living conditions, hair cortisol concentrations (HCC) and post-traumatic stress disorder (PTSD) symptoms in a large cohort of Syrian refugee children and adolescents (6-18 years) and their caregiver...
November 16, 2022: Molecular Psychiatry
#55
JOURNAL ARTICLE
John R Keefe, Benjamin Suarez-Jimenez, Xi Zhu, Amit Lazarov, Ariel Durosky, Sara Such, Caroline Marohasy, Shmuel Lissek, Yuval Neria
BACKGROUND: Patients with posttraumatic stress disorder (PTSD) tend to overgeneralize threat to safe stimuli, potentially reflecting aberrant stimuli discrimination. Yet, it is not clear whether threat overgeneralization reflects general discrimination deficits, or rather a specific bias related to aversive stimuli. Here we tested this question and characterized the neural correlates of threat discrimination. METHODS: One-hundred and eight participants (33 PTSD; 43 trauma-exposed controls; 32 healthy controls) completed an emotionally neutral complex shape discrimination task involving identifying in 42 similar pairs the previously observed shape; and an emotionally aversive discrimination task, involving providing risk ratings for an aversive conditioned stimulus (CS+), and for several stimuli gradually differing in size from the original CS+...
November 6, 2022: Depression and Anxiety
#56
JOURNAL ARTICLE
Christopher S Stauffer, Melanie R Brown, Dee Adams, Marca Cassity, Jae Sevelius
Introduction: Transgender and gender diverse (TGD) people experience stigma, discrimination, trauma, and post-traumatic stress disorder (PTSD) at higher rates compared to the general population; however, TGD people have been underrepresented in PTSD research. Clinical trials of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy demonstrate promising safety and efficacy for the treatment of PTSD. Issues related to equitable access, power imbalances in the therapeutic relationship, and vulnerable states of consciousness occasioned by MDMA are magnified when working with people affected by structural vulnerabilities and health disparities, and community engagement in research planning and implementation is essential...
2022: Frontiers in Psychiatry
#57
JOURNAL ARTICLE
Renato Polimanti, Frank R Wendt, Gita A Pathak, Daniel S Tylee, Catherine Tcheandjieu, Austin T Hilliard, Daniel F Levey, Keyrun Adhikari, J Michael Gaziano, Christopher J O'Donnell, Themistocles L Assimes, Murray B Stein, Joel Gelernter
The association between coronary artery disease (CAD) and posttraumatic stress disorder (PTSD) contributes to the high morbidity and mortality observed for these conditions. To understand the dynamics underlying PTSD-CAD comorbidity, we investigated large-scale genome-wide association (GWA) statistics from the Million Veteran Program (MVP), the UK Biobank (UKB), the Psychiatric Genomics Consortium, and the CARDIoGRAMplusC4D Consortium. We observed a genetic correlation of CAD with PTSD case-control and quantitative outcomes, ranging from 0...
August 19, 2022: Molecular Psychiatry
#58
JOURNAL ARTICLE
Ryan Freshman, Jacob F Oeding, Christopher Anigwe, Alan Zhang, Brian Feeley, C Benjamin Ma, Drew A Lansdown
PURPOSE: To investigate the association between pre-operative mental health disorders and post-operative complications, readmissions, and ipsilateral revision procedures amongst patients undergoing arthroscopic rotator cuff repair (RCR). METHODS: A retrospective cohort study from 2010 to 2020 was performed using the PearlDiver database. Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes were used to compare patients with and without mental health disorders who underwent arthroscopic RCR...
August 12, 2022: Arthroscopy
#59
JOURNAL ARTICLE
Nathaniel G Harnett, Katherine E Finegold, Lauren A M Lebois, Sanne J H van Rooij, Timothy D Ely, Vishnu P Murty, Tanja Jovanovic, Steven E Bruce, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Michael C Kurz, Robert A Swor, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Erica Harris, Anna M Chang, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Mark W Miller, Robert H Pietrzak, Jutta Joormann, Deanna M Barch, Diego A Pizzagalli, John F Sheridan, Steven E Harte, James M Elliott, Ronald C Kessler, Karestan C Koenen, Samuel A McLean, Lisa D Nickerson, Kerry J Ressler, Jennifer S Stevens
Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression...
August 8, 2022: Translational Psychiatry
#60
JOURNAL ARTICLE
Jonathan Jin, Kyle Weiman, Suzette Bremault-Phillips, Eric Vermetten
Introduction: In the course of service, military members, leaders, and uniformed professionals are at risk of exposure to potentially morally injurious events (PMIEs). Serious mental health consequences including Moral Injury (MI) and Post-traumatic stress disorder (PTSD) can result. Guilt, shame, spiritual/existential conflict, and loss of trust are described as core symptoms of MI. These can overlap with anxiety, anger, re-experiencing, self-harm, and social problems commonly seen in PTSD...
2022: Frontiers in Psychiatry
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