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JOURNAL ARTICLE
Wenyu Yang, Guanghui Li, Jie Liu
BACKGROUND: Hip fracture is commonly in the elderly as a consequence of osteoporsis. Currently, China is entering an aging society and there is a lack of studies about the epidemiology and health burden of hip fracturs there. METHODS: We used data from the Global Burden of Disease study 2019 (GBD 2019) to estimate the incidence, prevalence and disease burden of hip fractures in China and the temporal trends from 1990 to 2019. These estimates were produced by DisMod-MR 2...
February 2024: Preventive Medicine Reports
#42
JOURNAL ARTICLE
Fatos Ramadani, Daniele Valsecchi, Cristina Goga, Philippe Otten, Gianluca Maestretti
Compression fractures of thoracolumbar vertebra are the most common vertebral fracture.1 Associated with osteoporosis, the compression can progress until reach vertebra plana and cause a kyphosis.2 The reduction of the fresh fracture and restoration of the height are the purposes of the kyphoplasty.3 We present a modified technique adapted for the treatment of vertebral plana using a mechanical flexible lamellar vertebral body reduction device (Tektona, Spinart).4 We present the case of a 77-year-old woman with back pain after a fall...
February 14, 2024: Operative Neurosurgery (Hagerstown, Md.)
#43
REVIEW
Ruili Jia, Yanhao Sun, Chong Liu, Rui-Chao Liu, Yubin Long
INTRODUCTION: Electrical injuries rarely result in fractures, such as long bone fractures and spinal fractures. A few articles have reported osteoporosis vertebral compression fractures (OVCFs) caused by electrical injuries. Here, we present a rare case of 37-year-old male suffering from the 9th thoracic (T9) and 5th lumbar (L5) OVCFs after receiving a electric shock. CASE PRESENTATION: A 37-year-old Han male experienced an electric shock (480 V direct current) at the working time and felt immediately serious back pain...
February 14, 2024: Journal of Medical Case Reports
#44
JOURNAL ARTICLE
Garrett S Bullock, Pamela Duncan, Alison M Chandler, Aylin A Aguilar, Nancy Latham, Tom Storer, Neil Alexander, Christine M McDonough
BACKGROUND: The purpose of this study was to develop a clinical support tool for osteoporosis clinic providers to support risk assessment and referrals for evidence-based exercise therapy programs. METHODS: A sequential Delphi method was used with a multidisciplinary group of national falls experts, to provide consensus on referral to exercise therapy for patients at risk for falls. The Delphi study included a primary research team, expert panel, and clinical partners to answer the questions: (1) "What patient characteristics are needed to develop a clinical support tool?"; (2) "What are the recommended exercise referrals for patients with osteoporosis at risk for falls?" The consensus process consisted of two rounds with 8 weeks between meetings...
February 12, 2024: Journal of the American Geriatrics Society
#45
JOURNAL ARTICLE
Gregorio Bevilacqua, Leo D Westbury, Ilse Bloom, Jean Zhang, Wendy T Lawrence, Mary E Barker, Kate A Ward, Elaine M Dennison
BACKGROUND: Social isolation and loneliness are prevalent among older adults. This study investigated factors influencing worsening social isolation and loneliness in community-dwelling older adults during the COVID-19 pandemic, focusing on musculoskeletal conditions, falls, and fractures. METHODS: We studied 153 participants from the Hertfordshire Cohort Study. Baseline assessments (2019-20) included osteoporosis, clinical osteoarthritis, fractures after age 45 years, falls in previous year, and lifestyle factors...
February 3, 2024: Aging Clinical and Experimental Research
#46
J Anthony Parker, Runhua Hou
BACKGROUND/OBJECTIVE: Patients with systemic mastocytosis are at high risk of developing osteoporosis and fractures. Herein, we report a case of hip fragility fracture in a patient with indolent systemic mastocytosis and normal bone density. CASE REPORT: A 48-year-old man experienced a left femoral neck fracture after a fall. After a dose of oxycodone/hydromorphone postoperatively, he developed an anaphylactic reaction. Previously, he experienced a few other episodes of flushing, dizziness, and syncope precipitated by stress and alcohol...
2024: AACE Clinical Case Reports
#47
JOURNAL ARTICLE
Serge Ferrari, Andrea Trombetti, Anne-Cecile Debrach, Sarah Kozycki, Ivan Padlina, Thierry Chevalley, Emmanuel Biver
The sequential effects of romosozumab and denosumab in osteoporosis are shown in real-life, while the mechanisms of post-denosumab rebound are reviewed extensively. A network meta-analysis confirms the superiority of anabolics vs anti-resorptives on fracture reduction, while the latter shown a reduction of mortality in a large population-based study. Fracture risk prediction by FRAXPlus is improved. New meta-analyses confirm the benefits of Vitamin D on fractures and falls. Finally, multiples trials with new molecules for the treatment of rare bone diseases, including osteogenesis imperfecta, fibrous dysplasia and hypoparathyroidism, shown promising results...
January 31, 2024: Revue Médicale Suisse
#48
JOURNAL ARTICLE
Yu-Dong Xia, Rong Zhang, Qiong Liu, Jia-Ru Chen
OBJECTIVE: To investigate the effect of bone cement containing recombinant human basic fibroblast growth factor (rhbFGF) and recombinant human bone morphogenetic protein-2 (rhBMP-2) in percutaneous kyphoplasty(PKP)treatment of osteoporotic vertebral compression fracture(OVCF). METHODS: A total of 103 OVCF patients who underwent PKP from January 2018 to January 2021 were retrospectively analyzed, including 40 males and 63 females, aged from 61 to 78 years old with an average of (65...
January 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
#49
REVIEW
Yesid Hurtado, Odismar Andrea Hernández, Diana Patricia Atencio De Leon, Gustavo Duque
Fragility fractures occur because of low-impact trauma or even spontaneously in individuals with osteoporosis. Caring for older persons with fragility fractures can present several challenges due to the unique needs and vulnerabilities of this population. Older individuals commonly have multiple medical conditions, such as osteoporosis, arthritis, cardiovascular diseases, and diabetes. These comorbidities can complicate fracture management and increase the risk of complications. Fracture repair through surgery may be more complex in older patients due to poor bone quality, decreased tissue elasticity, and higher chances of anesthesia complications...
2024: Clinical Interventions in Aging
#50
REVIEW
Toby O Smith, Oliver Brown, Mark A Baxter
PURPOSE: This systematic review aimed to understand older people's perspectives of associated fear-avoidant beliefs following upper limb fracture. METHODS: Published and unpublished literature databases were systematically searched from inception to 1st April 2023. Qualitative studies reporting the perspectives of fear-avoidant beliefs or behaviours in people who had sustained an upper limb fracture were eligible. Data extracted included characteristics of people interviewed, experiences and perceptions of fear, fear of falling, and fear-avoidant beliefs and behaviours...
January 27, 2024: Osteoporosis International
#51
JOURNAL ARTICLE
Variation, sexual dimorphism, and enlargement of the frontal sinus with age in adult South Africans.
Victoria A Greening, Emily Hernandez, Carrie S Mongle, Brendon K Billings, Victor Mngomezulu, Ian J Wallace, Frederick E Grine
OBJECTIVES: To document frontal sinus volume (FSV) in a sample of sub-Saharan Africans with a view to evaluating claims that such populations exhibit comparatively small sinuses. This study also addresses questions related to sexual dimorphism, incidence of sinus aplasia, and the possibility that FSV continues to increase through adulthood. MATERIALS AND METHODS: FSV was measured from CT scans of adult crania from the Dart Collection. Sex and age were known for each individual...
January 25, 2024: American journal of biological anthropology
#52
JOURNAL ARTICLE
Zixiang Geng, Peige Wang, Guangyue Yang, Yifei Li, Yongfang Zhao
BACKGROUND: Dysmobility syndrome based on osteoporosis (ODS) is a disease characterized by low bone mass and low muscle mass. Its features are high fracture and high fall risk. Falls and fractures are the most important factors affecting the quality of life and lifespan of ODS. However, there is no serum marker for the evaluation of ODS patients.Our previous studies have shown that the expression of circulating miRNA is stable and is a good marker for disease diagnosis. Therefore, this study aims to explore potential serum markers of ODS...
January 23, 2024: Postgraduate Medical Journal
#53
JOURNAL ARTICLE
Liesbeth Vandenput, Helena Johansson, Eugene V McCloskey, Enwu Liu, Marian Schini, Kristina E Åkesson, Fred A Anderson, Rafael Azagra, Cecilie L Bager, Charlotte Beaudart, Heike A Bischoff-Ferrari, Emmanuel Biver, Olivier Bruyère, Jane A Cauley, Jacqueline R Center, Roland Chapurlat, Claus Christiansen, Cyrus Cooper, Carolyn J Crandall, Steven R Cummings, José A P da Silva, Bess Dawson-Hughes, Adolfo Diez-Perez, Alyssa B Dufour, John A Eisman, Petra J M Elders, Serge Ferrari, Yuki Fujita, Saeko Fujiwara, Claus-Christian Glüer, Inbal Goldshtein, David Goltzman, Vilmundur Gudnason, Jill Hall, Didier Hans, Mari Hoff, Rosemary J Hollick, Martijn Huisman, Masayuki Iki, Sophia Ish-Shalom, Graeme Jones, Magnus K Karlsson, Sundeep Khosla, Douglas P Kiel, Woon-Puay Koh, Fjorda Koromani, Mark A Kotowicz, Heikki Kröger, Timothy Kwok, Olivier Lamy, Arnulf Langhammer, Bagher Larijani, Kurt Lippuner, Fiona E A McGuigan, Dan Mellström, Thomas Merlijn, Tuan V Nguyen, Anna Nordström, Peter Nordström, Terence W O'Neill, Barbara Obermayer-Pietsch, Claes Ohlsson, Eric S Orwoll, Julie A Pasco, Fernando Rivadeneira, Anne-Marie Schott, Eric J Shiroma, Kristin Siggeirsdottir, Eleanor M Simonsick, Elisabeth Sornay-Rendu, Reijo Sund, Karin M A Swart, Pawel Szulc, Junko Tamaki, David J Torgerson, Natasja M van Schoor, Tjeerd P van Staa, Joan Vila, Nicholas J Wareham, Nicole C Wright, Noriko Yoshimura, MCarola Zillikens, Marta Zwart, Nicholas C Harvey, Mattias Lorentzon, William D Leslie, John A Kanis
UNLABELLED: The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. INTRODUCTION: Previous falls are a well-documented risk factor for subsequent fracture but have not yet been incorporated into the FRAX algorithm...
January 17, 2024: Osteoporosis International
#54
JOURNAL ARTICLE
Bernardo Abel Cedeno-Veloz, Irache Casadamon-Munarriz, Alba Rodríguez-García, Lucia Lozano-Vicario, Fabricio Zambom-Ferraresi, María Gonzalo-Lázaro, Ángel María Hidalgo-Ovejero, Mikel Izquierdo, Nicolás Martínez-Velilla
INTRODUCTION: Hip fractures are the most common fracture leading to hospitalization and are associated with high costs, mortality rates and functional decline. Although several guidelines exist for preventing new fractures and promoting functional recovery, they tend to focus on osteoporosis treatment and do not take into account the complexity of frailty in older adults and geriatric syndromes, which are important factors in individuals at risk of suffering from frailty fractures. Moreover, most health systems are fragmented and are incapable of providing appropriate management for frail and vulnerable individuals who are at risk of experiencing fragility fractures...
December 23, 2023: Journal of Clinical Medicine
#55
JOURNAL ARTICLE
Miriam T Y Leung, Justin P Turner, Clara Marquina, Jenni Ilomaki, Tim Tran, J Simon Bell
UNLABELLED: Bisphosphonates prevent future hip fractures. However, we found that one in six patients with hip fractures had a delay in bisphosphonate initiation and another one-sixth discontinued treatment within 12 months after discharge. Our results highlight the need to address hesitancy in treatment initiation and continuous monitoring. PURPOSE: Suboptimal antiresorptive use is not well understood. This study investigated trajectories of oral bisphosphonate use following first hip fractures and factors associated with different adherence and persistence trajectories...
January 10, 2024: Osteoporosis International
#56
Fahad Alhelal, Sami Alissa, Majed Abaalkhail, Abdullah Alshehri, Abdullah Alsaeed, Joud Bindekhayel
The role of vision in maintaining postural stability is crucial, and its loss, whether congenital or acquired, can significantly impact sensory-motor interactions, leading to musculoskeletal abnormalities and defective gait patterns. This case report discusses the complex interplay between visual impairment, post-traumatic kyphosis, and the development of spinal deformity in a 79-year-old blind patient. The patient sustained a simple fall resulting in an L1 compression fracture in 2016. Despite conservative treatment for the fracture, progressive spinal deformity became evident both clinically and radiographically...
December 2023: Curēus
#57
REVIEW
James Webster, Jack Dalla Via, Christina Langley, Cassandra Smith, Craig Sale, Marc Sim
Falls and osteoporotic fractures are a major public health problem, particularly among older adults. A third of individuals aged 65 years and over fall at least once each year, with up to 20 % of these resulting in serious injury, including fracture. In conjunction with regular exercise, the importance of diet for musculoskeletal health has largely focused upon calcium, vitamin D, and protein, particularly in the context of preventing falls and fractures. Whilst there is evidence for the benefits of these nutrients for musculoskeletal health, other aspects of the diet remain largely underexplored...
December 2023: Bone Reports
#58
JOURNAL ARTICLE
Ahmad Delbari, Amirali Azimi, Morvarid Najafi, Mohammad Saatchi, Mohammad Bidkhori, Mohammad Ebrahim Mousavi, Fatemeh-Sadat Tabatabaei, Elham Hooshmand
INTRODUCTION: The objective of this study was to assess the prevalence of falls, fear of falling (FOF), complications arising from falls, and identify possible sociodemographic and health-related factors associated with these outcomes among older adults. METHODS: This cross-sectional study was based on the first wave of the Ardakan Cohort Study on Aging (ACSA), which includes participants over 50 years of age residing in Ardakan, Iran. Fall history, number of fall events, FOF, hospitalizations, and fractures in the past 12 months were assessed through a face-to-face interview...
2024: Archives of Academic Emergency Medicine
#59
JOURNAL ARTICLE
Perry Lim, Aaron J Clark, Vedat Deviren, Sigurd H Berven, Shane Burch, Christopher P Ames, Alekos A Theologis
PURPOSE: To define the prevalence, characteristics, and treatment approach for proximal junction failure secondary to odontoid fractures in patients with prior C2-pelvis posterior instrumented fusions (PSF). METHODS: A single institution's database was queried for multi-level fusions (6+ levels), including a cervical component. Posterior instrumentation from C2-pelvis and minimum 6-month follow-up was inclusion criteria. Patients who sustained dens fractures were identified; each fracture was subdivided based on Anderson & D'Alonzo and Grauer's classifications...
December 29, 2023: Spine Deformity
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JOURNAL ARTICLE
Zhenqi Sang, Zhixia Jiang, Sha Liu, Pingyu Ye, Sijing Hu, Qiaoyan Zhang, Yan Zhu, Luping Qin, Qiming Zhao
Compared with traditional tedious organic solvent-assisted separation process in natural medicinal chemistry, cytomembrane (CM) fishing technique became a more appealing and greener choice for screening bioactive components from natural products. However, its large-scale practical value was greatly weakened by the easy fall-off of CMs from magnetic supports, rooted in the instability of common Fe3 O4 particles and their insufficient interaction with CMs. In this research, a new green biostable platform was developed for drug screening through the integration of hyperbranched quaternized hydrothermal magnetic carbon spheres (HQ-HMCSs) and CMs...
December 26, 2023: International Journal of Biological Macromolecules
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