Tobias Petzold, Manuela Thienel, Lisa Dannenberg, Philipp Mourikis, Carolin Helten, Aysel Ayhan, René M'Pembele, Alina Achilles, Kajetan Trojovky, Daniel Konsek, Zhe Zhang, Ron Regenauer, Joachim Pircher, Andreas Ehrlich, Enzo Lüsebrink, Leo Nicolai, Thomas J Stocker, Richard Brandl, Franz Röschenthaler, Jan Strecker, Inas Saleh, Michael Spannagl, Christoph H Mayr, Herbert B Schiller, Christian Jung, Norbert Gerdes, Till Hoffmann, Bodo Levkau, Thomas Hohlfeld, Tobias Zeus, Christian Schulz, Malte Kelm, Amin Polzin
RATIONALE: A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban compared with vitamin K antagonists. At the same time, low-dose rivaroxaban has been shown to reduce mortality and atherothrombotic events in patients with coronary artery disease. Yet, the mechanisms underlying this reduction remain unknown. OBJECTIVE: In this study, we hypothesized that rivaroxaban's antithrombotic potential is linked to a hitherto unknown rivaroxaban effect that impacts on platelet reactivity and arterial thrombosis...
February 14, 2020: Circulation Research