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atrial fibrillation GERD

Toru Maruyama, Mitsuhiro Fukata, Koichi Akashi
Atrial fibrillation (AF) is a common arrhythmia and gastroesophageal reflux disease (GERD) is popular in Japan. The two common diseases share several predisposing factors such as lifestyle and senescence, and inflammation and oxidative stress play an important role in their development and progression. Incidental cases of AF treated successfully by proton pump inhibitor (PPI) applied for coexisting GERD have been sporadically reported. An increasing evidence indicates that GERD induces the initiation and the perpetuation of AF...
February 2019: Journal of Arrhythmia
Charlotte Eitel, Hueseyin Ince, Johannes Brachmann, Karl-Heinz Kuck, Stephan Willems, Jin-Hong Gerds-Li, Juergen Tebbenjohanns, Gert Richardt, Matthias Hochadel, Jochen Senges, Roland R Tilz
BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare. METHODS AND RESULTS: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188)...
February 20, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Kathleen Nolte, Christoph Herrmann-Lingen, Lars Platschek, Volker Holzendorf, Stefan Pilz, Andreas Tomaschitz, Hans-Dirk Düngen, Christiane E Angermann, Gerd Hasenfuß, Burkert Pieske, Rolf Wachter, Frank Edelmann
AIMS: Vitamin D deficiency is prevalent in heart failure (HF), but its relevance in early stages of heart failure with preserved ejection fraction (HFpEF) is unknown. We tested the association of 25-hydroxyvitamin D [25(OH)D] serum levels with mortality, hospitalizations, cardiovascular risk factors, and echocardiographic parameters in patients with asymptomatic diastolic dysfunction (DD) or newly diagnosed HFpEF. METHODS AND RESULTS: We measured 25(OH)D serum levels in outpatients with risk factors for DD or history of HF derived from the DIAST-CHF study...
February 19, 2019: ESC Heart Failure
Marlena Schnieder, Tariq Siddiqui, André Karch, Mathias Bähr, Gerd Hasenfuß, Marco R Schroeter, Jan Liman
BACKGROUND: About 25% of strokes are thought to be cryptogenic. There is growing evidence that most of these cryptogenic strokes are thromboembolic and caused by an undetected atrial fibrillation. Measured slow flow in the left atrial appendage has been proposed to be an indicator for the thromboembolic risk since it is possibly associated with undetected atrial fibrillation. METHODS: We evaluated all patients (n = 909; mean of 62 years, 39% female) admitted with an ischemic stroke (84%) or transient ischemic attack to our university medical center who underwent transesophageal echocardiography examination 2012-2014...
November 27, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Tobias Tichelbäcker, Leonard Bergau, Miriam Puls, Tim Friede, Tobias Mütze, Lars Siegfried Maier, Norbert Frey, Gerd Hasenfuß, Markus Zabel, Claudius Jacobshagen, Samuel Sossalla
BACKGROUND: Permanent pacemaker implantation (PPI) following TAVR is a frequent post interventional complication and its management remains controversial. OBJECTIVE: We sought to elucidate the electrophysiological, procedural, and clinical baseline parameters that are associated with and perhaps predict the need for PPI after TAVR in a heterogeneous-valve-type real-world cohort. METHODS: Overall, 494 patients receiving TAVR at our center from April 2009 to August 2015 were screened...
2018: PloS One
Johannes T Kowallick, Wieland Staab, Andreas Schuster, Sören J Backhaus, Mark Weber-Krüger, Lukas Bauer, Christian Sohns, Joachim Lotz, Gerd Hasenfuß, Lars Lüthje, Markus Zabel, Leonard Bergau
BACKGROUND: Catheter ablation of atrial fibrillation (AF) improves left ventricular (LV) function in patients with LV systolic dysfunction, suggestive of underlying arrhythmia-induced adverse remodeling. OBJECTIVES: The objectives of this study were to evaluate whether arrhythmia-induced LV remodeling occurs in patients with AF and preserved LV systolic function and to assess whether this remodeling is reversible after restoration of sinus rhythm by catheter ablation...
September 21, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Troels H Jørgensen, Ole De Backer, Thomas A Gerds, Gintautas Bieliauskas, Jesper H Svendsen, Lars Søndergaard
OBJECTIVES: The aim of this study was to use a 12-lead electrocardiogram obtained immediately post-transcatheter aortic valve replacement (TAVR) to identify predictors of late high-degree conduction defect (HD-CD) within 30 days after TAVR. BACKGROUND: There are limited data on risk factors for the development of late HD-CD and the need to retain the temporary pacemaker after TAVR. METHODS: A single-center study was conducted including 467 consecutive patients, without pre-procedural pacemakers, undergoing TAVR...
August 13, 2018: JACC. Cardiovascular Interventions
Laura P B Elbers, Alessandro Squizzato, Victor E A Gerdes
Lower levels of free thyroxine (whether this is endogenous or exogenous) lead to a hypocoagulable state, and higher levels of free thyroxine lead to a hypercoagulable state. In this narrative review, the effects of different levels of thyroid hormones on clinical end points are described. Hypothyroidism is associated with an increased bleeding risk, whereas hyperthyroidism leads to an increased risk of venous thrombosis. Besides, effects of thyroid hormone on the heart may indirectly influence hemostasis. Hyperthyroidism leads to a higher incidence of atrial fibrillation and atrial flutter, and, at least partly by that mechanism, a higher risk of cerebral arterial thrombosis...
October 2018: Seminars in Thrombosis and Hemostasis
Leonard Bergau, Rik Willems, David J Sprenkeler, Thomas H Fischer, Panayota Flevari, Gerd Hasenfuß, Dimitrios Katsaras, Aleksandra Kirova, Stephan E Lehnart, Lars Lüthje, Christian Röver, Joachim Seegers, Samuel Sossalla, Albert Dunnink, Rajevaa Sritharan, Anton E Tuinenburg, Bert Vandenberk, Marc A Vos, Sofieke C Wijers, Tim Friede, Markus Zabel
BACKGROUND AND OBJECTIVE: We prospectively investigated combinations of risk stratifiers including multiple EP diagnostics in a cohort study of ICD patients. METHODS: For 672 enrolled patients, we collected history, LVEF, EP study and T-wave alternans testing, 24-h Holter, NT-proBNP, and the eGFR. All-cause mortality and first appropriate ICD shock were predefined endpoints. RESULTS: The 635 patients included in the final analyses were 63 ± 13 years old, 81% were male, LVEF averaged 40 ± 14%, 20% were inducible at EP study, 63% had a primary prophylactic ICD...
December 1, 2018: International Journal of Cardiology
Christina Ji-Young Lee, Thomas Alexander Gerds, Nicholas Carlson, Anders Nissen Bonde, Gunnar Hilmar Gislason, Morten Lamberts, Jonas Bjerring Olesen, Jannik Langtved Pallisgaard, Morten Lock Hansen, Christian Torp-Pedersen
BACKGROUND: Evidence is conflicting as to the efficacy of direct oral anticoagulation (DOAC) and vitamin K antagonist (VKA) for prevention of myocardial infarction (MI). OBJECTIVES: This study aimed to investigate the risk of MI associated with the use of apixaban, dabigatran, rivaroxaban, and VKA in patients with atrial fibrillation. METHODS: Patients with atrial fibrillation were identified using Danish health care registers and stratified by initial oral anticoagulant treatment...
July 3, 2018: Journal of the American College of Cardiology
Morten W Skov, Jonas Ghouse, Jørgen T Kühl, Pyotr G Platonov, Claus Graff, Andreas Fuchs, Peter V Rasmussen, Adrian Pietersen, Børge G Nordestgaard, Christian Torp-Pedersen, Steen M Hansen, Morten S Olesen, Stig Haunsø, Lars Køber, Thomas A Gerds, Klaus F Kofoed, Jesper H Svendsen, Anders G Holst, Jonas B Nielsen
BACKGROUND: The electrocardiographic interatrial block (IAB) has been associated with atrial fibrillation (AF). We aimed to test whether IAB can improve risk prediction of AF for the individual person. METHODS AND RESULTS: Digital ECGs of 152 759 primary care patients aged 50 to 90 years were collected from 2001 to 2011. We identified individuals with P-wave ≥120 ms and the presence of none, 1, 2, or 3 biphasic P-waves in inferior leads. Data on comorbidity, medication, and outcomes were obtained from nationwide registries...
May 30, 2018: Journal of the American Heart Association
Helmut Lieder, Günter Breithardt, Gerd Heusch
Atrial fibrillation and coronary artery disease are highly prevalent diseases in an aging population. They share risk factors and are frequently associated. Beyond their mere association, they impact on each other. The positive feed-back between atrial fibrillation and acute myocardial ischemia involves sympathetic activation and may result in sudden death.
March 1, 2018: International Journal of Cardiology
Bawer Jalal Tofig, Peter Lukac, Rune Borregaard, Jan Møller Nielsen, Henrik Kjærulf Jensen, Christian Gerdes, Jens Kristensen, Jens Cosedis Nielsen, Steen Buus Kristiansen
OBJECTIVES: Recurrent arrhythmia after pulmonary vein isolation (PVI) by radiofrequency (RF) ablation in patients with atrial fibrillation (AFIB) remains a significant challenge. Using contact force (CF) sensing ablation catheters, we aimed to identify procedure related parameters associated with recurrence after de-novo PVI in patients with AFIB. METHODS: Consecutive patients undergoing a de-novo PVI procedure (n = 120, 63% paroxysmal and 37% persistent AFIB) employing a force-sensing ablation catheter were included...
February 2018: Scandinavian Cardiovascular Journal: SCJ
Laila Staerk, Emil Loldrup Fosbøl, Morten Lamberts, Anders Nissen Bonde, Kasper Gadsbøll, Caroline Sindet-Pedersen, Ellen A Holm, Thomas Alexander Gerds, Brice Ozenne, Gregory Y H Lip, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Jonas Bjerring Olesen
Aims: We examined the risks of all-cause mortality, stroke, major bleeding, and recurrent traumatic injury associated with resumption of vitamin K antagonists (VKAs) and non-VKAs oral anticoagulants (NOACs) following traumatic injury in atrial fibrillation (AF) patients. Methods and results: This was a Danish nationwide registry-based study (2005-16), including 4541 oral anticoagulant (OAC)-treated AF patients experiencing traumatic injury (defined as traumatic brain injury, hip fracture, or traumatic torso or abdominal injury)...
May 14, 2018: European Heart Journal
Enia Lucia Coutinho, Fernando A M Herbella, Carlos Alexandre Volponi Lovato, Marco G Patti, Francisco Schlottmann, Angelo Amato Vincenzo de Paola
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Some evidence shows that gastroesophageal reflux disease (GERD) may be a trigger for paroxysmal AF (PAF). Most of the previous studies that correlated GERD and AF used questionnaires to diagnose GERD, not an objective evaluation. This study aims to evaluate in patients with PAF: (a) accuracy of symptoms to diagnose GERD; (b) prevalence of GERD; and (c) temporal correlation between cardiac arrhythmia and reflux...
May 2018: World Journal of Surgery
Caroline Sindet-Pedersen, Laila Staerk, Morten Lamberts, Thomas Alexander Gerds, Jeffrey S Berger, Anders Nissen Bonde, Jannik Langtved Pallisgaard, Morten Lock Hansen, Christian Torp-Pedersen, Gunnar H Gislason, Jonas Bjerring Olesen
OBJECTIVES: To investigate temporal trends in the use of non-vitamin K oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in combination with aspirin and/or clopidogrel in patients with atrial fibrillation (AF) following acute myocardial infarction (MI) and/or percutaneous coronary intervention (PCI). METHODS: Using Danish nationwide registries, all patients with AF who survived 30 days after discharge from MI and/or PCI between 22 August 2011 and 30 September 2016 were identified...
June 2018: Heart: Official Journal of the British Cardiac Society
Mark Weber-Krüger, Constanze Lutz, Antonia Zapf, Raoul Stahrenberg, Joachim Seegers, Janin Witzenhausen, Katrin Wasser, Gerd Hasenfuß, Klaus Gröschel, Rolf Wachter
OBJECTIVE: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. METHODS: Analysis is from the prospective Find-AF trial (ISRCTN46104198)...
October 10, 2017: Neurology
L Staerk, T A Gerds, G Y H Lip, B Ozenne, A N Bonde, M Lamberts, E L Fosbøl, C Torp-Pedersen, G H Gislason, J B Olesen
BACKGROUND: Comparative data of non-vitamin K antagonist oral anticoagulants (NOAC) are lacking in patients with atrial fibrillation (AF). OBJECTIVE: We compared effectiveness and safety of standard and reduced dose NOAC in AF patients. METHODS: Using Danish nationwide registries, we included all oral anticoagulant-naïve AF patients who initiated NOAC treatment (2012-2016). Outcome-specific and mortality-specific multiple Cox regressions were combined to compute average treatment effects as 1-year standardized differences in stroke and bleeding risks (g-formula)...
January 2018: Journal of Internal Medicine
Gijs E de Maat, Hendyke Z R Gerds-Ploeger, Massimo A Mariani, Isabelle C Van Gelder, Johan Brügemann, Michiel Rienstra
No abstract text is available yet for this article.
September 2015: HeartRhythm Case Reports
Rune Borregaard, Henrik Kjærulf Jensen, Bawer Jalal Tofig, Samuel Alberg Thrysøe, Christian Gerdes, Jens Cosedis Nielsen, Peter Lukac
OBJECTIVE: To investigate the effect of the operator knowing the real-time contact force (CF) on the efficacy of pulmonary vein antrum isolation (PVAI). METHODS: Fifty patients with paroxysmal atrial fibrillation (AF) or short lasting persistent AF were randomized to CF guided PVAI (n = 25) or conventional PVAI (n = 25). In the CF guided group, CF between 10 and 40 g was aimed at. Efficacy of PVAI was measured as reduction in AF burden (AFB) and time to AF recurrence detected by implantable cardiac monitor (ICM), inserted three months before PVAI...
June 2017: Scandinavian Cardiovascular Journal: SCJ
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