Leetah Senkpeil, Jyoti Bhardwaj, Morgan R Little, Prasida Holla, Aditi Upadhye, Elizabeth M Fusco, Phillip A Swanson Ii, Ryan E Wiegand, Michael D Macklin, Kevin Bi, Barbara J Flynn, Ayako Yamamoto, Erik L Gaskin, D Noah Sather, Adrian L Oblak, Edward Simpson, Hongyu Gao, W Nicholas Haining, Kathleen B Yates, Xiaowen Liu, Tooba Murshedkar, Thomas L Richie, B Kim Lee Sim, Kephas Otieno, Simon Kariuki, Xiaoling Xuei, Yunlong Liu, Rafael B Polidoro, Stephen L Hoffman, Martina Oneko, Laura C Steinhardt, Nathan W Schmidt, Robert A Seder, Tuan M Tran
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole sporozoite PfSPZ Vaccine in African infants. Innate immune activation and myeloid signatures at pre-vaccination baseline correlated with protection from Pf parasitemia in placebo controls. These same signatures were associated with susceptibility to parasitemia among infants who received the highest and most protective PfSPZ Vaccine dose...
April 30, 2024: JCI Insight