Yufeng Wang, Haiwen Zhou, Wenmei Wang, Ning Duan, Zhixiao Luo, Hongbo Chai, Lu Jiang, Qianming Chen, Jinli Liu, Hong Hua, Zhimin Yan, Yuan Fan, Juanyong Xu, Xiaobing Guan, Hongjian Wang, Hongzhou Lu, Wenhui Lun, Wei Fei, Tong Zhang, Jizhi Zhao, Chunling Jia, Hui Kong, Xuemin Shen, Qing Liu, Weizhi Wang, Guoyao Tang
Oropharyngeal candidiasis (OPC) is an opportunistic infection treated with anti-fungal agents. Herein, we evaluate the efficacy and safety of miconazole buccal tablets (MBT) and itraconazole capsules in the localized treatment of patients with OPC. In this multi-centered, double-blinded, phase III trial (CTR20130414), both males and non-pregnant females (≥18 years) with OPC were randomized (1:1) to MBT plus placebo (experimental group) or itraconazole capsules plus placebo (control group). The primary endpoint was clinical cure at the end-of-treatment period [visit 4 (V4)] while secondary endpoints were clinical remission rates, partial remission rates, mycological cure, clinical relapse, and adverse events (AEs)...
September 23, 2022: Medical Mycology