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https://read.qxmd.com/read/30723851/ph-responsive-polymeric-nanocarriers-for-efficient-killing-of-cariogenic-bacteria-in-biofilms
#1
Zhouxiang Zhao, Chunmei Ding, Yaqin Wang, Hong Tan, Jianshu Li
Traditional antibacterial treatments, such as chlorhexidine (CHX), destroy cariogenic biofilms. However, they exert negative effects in clinical applications, for example, teeth staining, taste disturbance and harm to oral tissue after a long-term exposure. Therefore, biocompatible strategies for efficient antibacterial drug delivery are in high demand. In this study, aimed at dental caries therapy enhancement, we designed a pH-responsive nanocarrier system, capable of releasing CHX in an acidic environment within cariogenic biofilms...
February 6, 2019: Biomaterials Science
https://read.qxmd.com/read/30717480/carminic-acid-stabilized-with-aluminum-magnesium-hydroxycarbonate-as-new-colorant-reducing-flammability-of-polymer-composites
#2
Anna Marzec, Bolesław Szadkowski, Jacek Rogowski, Waldemar Maniukiewicz, Dariusz Moszyński, Przemysław Rybiński, Marian Zaborski
In this study, hybrid pigments based on carminic acid (CA) were synthesized and applied in polymer materials. Modification of aluminum-magnesium hydroxycarbonate (LH) with CA transformed the soluble chromophore into an organic-inorganic hybrid colorant. Secondary ion mass spectroscopy (TOF-SIMS), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and UV-Vis spectroscopy were used to study the structure, composition, and morphology of the insoluble LH/CA colorant...
February 3, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30693519/influence-of-the-ethylene-related-signal-inhibiting-octapeptide-nop-1-on-postharvest-ripening-and-quality-of-golden-delicious-apples
#3
Simone Klein, Antje Fiebig, Daniel Neuwald, Dominik Dluhosch, Lena Müller, Georg Groth, Georg Noga, Mauricio Hunsche
BACKGROUND: Processes extending shelf-life of climacteric fruit play an important role in terms of a sustainable global food supply. In a previous study, a synthetic octapeptide (NOP-1) was shown to inhibit the interaction between ETR (ethylene receptor) and EIN2 (ethylene insensitive-2), and in consequence delay tomato ripening. We investigated for the first time the effect of NOP-1 to inhibit the ripening of apples (Golden Delicious) during postharvest. RESULTS: Using purified recombinant proteins from a bacterial expression system, we demonstrate here that EIN2 also interacts tightly (Kd = 136 +/- 29 nM) with the corresponding apple ethylene receptor MdETR1...
January 29, 2019: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/30668991/silver-nanoparticle-impregnated-chitosan-peg-hydrogel-enhances-wound-healing-in-diabetes-induced-rabbits
#4
Nosheen Masood, Rashid Ahmed, Muhammad Tariq, Zahoor Ahmed, Muhammad Shareef Masoud, Imran Ali, Rehana Asghar, Anisa Andleeb, Anwarul Hasan
Non-healing wounds are among the serious complications of type-2-diabetes around the globe, associated with high incidence of bacterial infection, chronic nerve and blood vessel damage, and eventually repeated amputation of limbs and organs. Silver nanoparticles offer strong wound healing potential due to their well-known antibacterial activities. The present study reports the development of silver nanoparticle impregnated chitosan-poly ethylene glycol (PEG) hydrogel to accelerate wound healing in diabetic patients...
January 19, 2019: International Journal of Pharmaceutics
https://read.qxmd.com/read/30606517/targeted-delivery-of-etoposide-carmustine-and-doxorubicin-to-human-glioblastoma-cells-using-methoxy-poly-ethylene-glycol-%C3%A2-poly-%C3%AE%C2%B5%C3%A2-caprolactone-nanoparticles-conjugated-with-wheat-germ-agglutinin-and-folic-acid
#5
Yung-Chih Kuo, Yu-Hsuan Chang, Rajendiran Rajesh
Wheat germ agglutinin (WGA) and folic acid (FA)-grafted methoxy poly(ethylene glycol) (MPEG)‑poly(ε‑caprolactone) (PCL) nanoparticles (WFNPs) were applied to transport anticancer drugs across the blood-brain barrier and treat glioblastoma multiforme (GBM). PCL was copolymerized with MPEG, and MPEG-PCL NPs were stabilized with pluronic F127 using a microemulsion-solvent evaporation technique and crosslinked with WGA and FA. The targeting ability of WFNPs loaded with etoposide (ETO), carmustine (BCNU) and doxorubicin (DOX) was investigated via the binding affinity of drug-loaded NP formulations to N‑acetylglucosamine expressed in human brain microvascular endothelial cells and to folate receptor in malignant U87MG cells...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30557680/methotrexate-loaded-biodegradable-polymeric-micelles-for-lymphoma-therapy
#6
MengYao Wang, Ying Qu, DanRong Hu, LiJuan Chen, Kun Shi, YanPeng Jia, YuYao Yi, Qing Wei, Ting Niu, ZhiYong Qian
Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive subtypes of lymphoma, such as Burkitt's lymphoma, in order to overcome drug resistance. But poor solubility of the free drug and severe side effects of HD MTX limit its clinical application. Polymeric micelle, as an ideal nano delivery system, provides effective solutions to these problems. In this work, monomethyl poly (ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) was employed to load MTX through a one-step solid dispersion method...
December 14, 2018: International Journal of Pharmaceutics
https://read.qxmd.com/read/30538447/enhanced-photo-chemo-combination-efficiency-against-bladder-tumor-by-encapsulation-of-dox-and-znpc-into-in-situ-formed-thermosensitive-polymer-hydrogel
#7
Zhongming Huang, He Xiao, Xiangyun Lu, Weigang Yan, Zhigang Ji
Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. This study reports the combination of doxorubicin (DOX)-based chemotherapy and zinc phthalocyanine (ZnPC)-based PDT using in situ-formed thermal-responsive copolymer hydrogel...
2018: International Journal of Nanomedicine
https://read.qxmd.com/read/30529658/can-drug-release-rate-from-implants-be-tailored-using-poly-urethane-mixtures
#8
Michael B Lowinger, Yongchao Su, Xingyu Lu, Robert O Williams, Feng Zhang
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic TPU ratio relative to varying ethylene vinyl acetate (EVA) crystallinity; (2) investigate the effect of mixture ratio on permeability of emtricitabine; and (3) investigate the impact of the extrusion process on mixing of the two TPUs and the resulting impact on drug diffusion...
December 6, 2018: International Journal of Pharmaceutics
https://read.qxmd.com/read/30529294/hydroxycamptothecin-nanoparticles-based-on-poly-oligo-ethylene-glycol-architecture-effects-of-nanocarriers-on-antitumor-efficacy
#9
Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong, Xiangtao Wang, Yanhong Wang
Nanoparticles decorated with hydrophilic PEG chains had been emerged as effective drug delivery system due to their biocompatibility and biodegradability, while, the influence of their architecture on antitumor efficacy remained challenging. In this study, the linear poly(ethylene glycol) (PEG45 ), brush oligo(triethylene glycol) (TEG10 ), and oligo(ethylene glycol) dendron (G2), which showed the similar molar mass but different architecture, were utilized as nanocarriers to prepare 10-hydroxycamptothecin (HCPT) nanoparticles...
December 5, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/30509181/preharvest-application-of-ethephon-and-postharvest-uv-b-radiation-improve-quality-traits-of-beetroot-beta-vulgaris-l-ssp-vulgaris-as-source-of-colourant
#10
Gregorio Barba-Espin, Stephan Glied-Olsen, Tsaneta Dzhanfezova, Bjarne Joernsgaard, Henrik Lütken, Renate Müller
BACKGROUND: Betanins have become excellent replacers for artificial red-purple food colourants. Red beet (Beta vulgaris L. spp. vulgaris) known as beetroot, is a rich source of betalains, which major forms are betanin (red to purple) and vulgaxanthin (yellow). Betalains and phenolic compounds are secondary metabolites, accumulation of which is often triggered by elicitors during plant stress responses. In the present study, pre-harvest applications of ethephon (an ethylene-releasing compound) and postharvest UV-B radiation were tested as elicitors of betalains and phenolic compounds in two beetroot cultivars...
December 3, 2018: BMC Plant Biology
https://read.qxmd.com/read/30497010/immunofunctional-photodegradable-poly-ethylene-glycol-hydrogel-surfaces-for-the-capture-and-release-of-rare-cells
#11
Paige J LeValley, Mark W Tibbitt, Ben Noren, Prathamesh Kharkar, April M Kloxin, Kristi S Anseth, Mehmet Toner, John Oakey
Circulating tumor cells (CTCs) play a central role in cancer metastasis and represent a rich source of data for cancer prognostics and therapeutic guidance. Reliable CTC recovery from whole blood therefore promises a less invasive and more sensitive approach to cancer diagnosis and progression tracking. CTCs, however, are exceedingly rare in whole blood, making their quantitative recovery challenging. Several techniques capable of isolating these rare cells have been introduced and validated, yet most suffer from low CTC purity or viability, both of which are essential to develop a clinically viable CTC isolation platform...
November 20, 2018: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/30479928/development-of-biocompatible-ha-hydrogels-embedded-with-a-new-synthetic-peptide-promoting-cellular-migration-for-advanced-wound-care-management
#12
Sun Young Wang, Hyosuk Kim, Gijung Kwak, Hong Yeol Yoon, Sung Duk Jo, Ji Eun Lee, Daeho Cho, Ick Chan Kwon, Sun Hwa Kim
In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide...
November 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/30477300/microfluidic-manufacturing-of-sn-38-loaded-polymer-nanoparticles-with-shear-processing-control-of-drug-delivery-properties
#13
Yi-Meng Cao, Lisa K Silverman, Changhai Lu, Rebecca Hof, Jeremy E Wulff, Matthew G Moffitt
Two-phase gas-liquid microfluidic reactors provide shear processing control of SN-38-loaded polymer nanoparticles (SN-38-PNPs). We prepare SN-38-PNPs from the block copolymer poly(methyl caprolactone-co-caprolactone)-block-poly(ethylene oxides) (P(MCL-co-CL)-b-PEO) using bulk and microfluidic methods and at different drug-to-polymer loading ratios and on-chip flow rates. We show that as the microfluidic flow rate (Q) increases, encapsulation efficiency and drug loading increase and release half times increase...
November 26, 2018: Molecular Pharmaceutics
https://read.qxmd.com/read/30362476/acid-active-supramolecular-anticancer-nanoparticles-based-on-cyclodextrin-polyrotaxanes-damaging-both-mitochondria-and-nuclei-of-tumor-cells
#14
Shuang Bai, Xiaoli Zhang, Xiaoqian Ma, Jiucun Chen, Qiubing Chen, Xiaoxiao Shi, Meili Hou, Peng Xue, Yuejun Kang, Zhigang Xu
As a supramolecular macrocyclic polymer, cyclodextrin (CD) polyrotaxanes (PRs) have many advantages for developing nanomedicines, such as stable chemical composition, abundant functionalized hydroxyl groups, moving across biological barriers, adjustable nanoparticle size and good biocompatibility. Herein, we synthesized a class of acid-active therapeutic nanoparticles comprising a α-CD-based PR polymeric prodrug of PRs-poly(doxorubicin)-co-poly[(ethylene glycol) methyl ether methacrylate] (PR-PDOX-co-POEGMA, denoted as PRMO@DOX) to reduce drug leakage and selectively deliver drugs into tumor cells, aiming to achieve maximal treatment efficacy of supramolecular therapeutics...
November 20, 2018: Biomaterials Science
https://read.qxmd.com/read/30360105/cascade-cytosol-delivery-of-dual-sensitive-micelle-tailored-vaccine-for-enhancing-cancer-immunotherapy
#15
Dandan Jiang, Weiwei Mu, Xiuping Pang, Yongjun Liu, Na Zhang, Yunmei Song, Sanjay Garg
Enhancing cytosol delivery of exogenous antigens in antigen presenting cells can improve cross-presentation and CD8+ T cell-mediated immune response. The antigen cytosol delivery speed, which has great importance on the rate of MHC class I molecules (MHC I) antigen presentation pathway and cytotoxic T lymphocytes (CTLs) induction, has not been well studied. We hypothesized that micelle-tailored vaccine with multiple cascaded lysosomal responsive capabilities could accelerate lysosomal escape and enhance cancer immunotherapy...
October 15, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30321641/peptide-functionalized-and-high-drug-loaded-novel-nanoparticles-as-dual-targeting-drug-delivery-system-for-modulated-and-controlled-release-of-paclitaxel-to-brain-glioma
#16
Primiano Pio Di Mauro, Anna Cascante, Pau Brugada Vilà, Vanessa Gómez-Vallejo, Jordi Llop, Salvador Borrós
A dual-targeting drug delivery system for paclitaxel (PTX) was developed by functionalizing novel polyester-based nanoparticles (NPs) with peptides possessing special affinity for low-density lipoprotein receptor (LDLR), overcoming the limitations of the current chemotherapeutics, to transport drug from blood to brain, and then target glioma cells. Employing novel biodegradable block co-polymers (P and 2P), PTX loaded and peptide-functionalized nanoparticles were prepared by a modified nano-co-precipitation method, carried out in one step only without emulsifier, allowing to obtain spherical nanometric (<200 nm), monodisperse (PDI ∼ 0...
October 12, 2018: International Journal of Pharmaceutics
https://read.qxmd.com/read/30295090/biodegradable-microsphere-hydrogel-ocular-drug-delivery-system-for-controlled-and-extended-release-of-bioactive-aflibercept-in-vitro
#17
Wenqiang Liu, Bao-Shiang Lee, William F Mieler, Jennifer J Kang-Mieler
PURPOSE: Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive aflibercept in a controlled and extended manner for 6 months. MATERIALS AND METHODS: The DDS was fabricated by suspending aflibercept-loaded poly(lactic-co-glycolic acid) microspheres within a biodegradable poly(ethylene glycol)-co-(l-lactic acid) diacrylate/N-isopropylacrylamide (PEG-PLLA-DA/NIPAAm) thermoresponsive hydrogel...
October 7, 2018: Current Eye Research
https://read.qxmd.com/read/30248847/effect-of-hydrolyzed-protein-based-mulching-coatings-on-the-soil-properties-and-productivity-in-a-tunnel-greenhouse-crop-system
#18
Luciana Sartore, Evelia Schettini, Laura de Palma, Gennaro Brunetti, Claudio Cocozza, Giuliano Vox
Polymeric protein-based biocomposites were used in this work as water dispersions to generate, in situ, biobased mulching coatings by spray technique, as alternative to low density polyethylene films for soil mulching. At the end of their lifetime, these biodegradable coatings degrade in soil thank to the microbial community that mineralizes them. Protein hydrolysates (PH) were derived from waste products of the leather industry, while poly(ethylene glycol) diglycidyl ether (PEG) and epoxidized soybean oil (ESO) were used to make the biodegradable spray coatings...
December 15, 2018: Science of the Total Environment
https://read.qxmd.com/read/30226512/phosphonium-hydrogels-for-controlled-release-of-ionic-cargo
#19
Tristan D Harrison, Paul J Ragogna, Elizabeth R Gillies
We describe the synthesis of three different phosphonium salts and their reaction with poly(ethylene glycol) dimethacrylate to create cationic hydrogels. The hydrogels were loaded with an anionic dye and an anionic anti-inflammatory drug through ionic interactions and compared with an analogous ammonium gel. The release rates of these anions depended on their structure and pKa values, as well as the pH and ionic strength of the release medium.
October 2, 2018: Chemical Communications: Chem Comm
https://read.qxmd.com/read/30184758/synthesis-and-characterization-of-paclitaxel-imprinted-microparticles-for-controlled-release-of-an-anticancer-drug
#20
Jianwei Bai, Yunan Zhang, Longqi Chen, Huijun Yan, Chunhong Zhang, Lijia Liu, Xiaodong Xu
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
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