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JOURNAL ARTICLE
Katarzyna Wątor, Piotr Rusiniak, Ewa Kmiecik, Ryszard Bugno, Vesna Ristić Vakanjac
Bottled mineral and spring water constitute one of the main sources of drinking water. Relevant legal acts in each country individually regulate the highest permitted concentrations of harmful substances in these waters. However, current regulations do not take into account newly emerging contaminants such as BPA. Analysis of the chemical composition of 72 bottled waters from the Polish market showed that undesirable elements occur in quantities that do not exceed the maximum permissible concentrations. Special attention should be paid to bottled therapeutic water, which may contain elevated concentrations of some micronutrients, such as Al, B, Ba, Fe, Mn, or Sr contributing to the pattern of health risk with excessive consumption of this type of water...
May 2, 2024: Environmental Geochemistry and Health
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JOURNAL ARTICLE
A U Bugubayeva, V N Chashkov, K K Valiev, S B Kuanyshbayev, A N Kupriyanov, S V Mamikhin, A B Nugmanov, A V Shcheglov, A G Bulaev, T A Paramonova, A Joldassov, M Uxikbayeva
Due to the need to achieve the principles of sustainable development and to understand the processes of formation of phytocenoses in areas that were adversely affected by the industrial impact, this study assessed the condition of the Grachevsky uranium mine (Kazakhstan), which underwent conservation procedures about 25 years ago. The purpose is to determine the level of water quality and phytocenosis of the shores of the reservoir accumulating natural effluents from reclaimed dumps and anthropogenic sites of a uranium mine, as well as quality indicators and toxicology...
2024: Brazilian Journal of Biology
#23
JOURNAL ARTICLE
Tina R Goldstein, John Merranko, Danella Hafeman, Mary Kay Gill, Fangzi Liao, Craig Sewall, Heather Hower, Lauren Weinstock, Shirley Yen, Benjamin Goldstein, Martin Keller, Michael Strober, Neal Ryan, Boris Birmaher
OBJECTIVES: To build a one-year risk calculator (RC) to predict individualized risk for suicide attempt in early-onset bipolar disorder. METHODS: Youth numbering 394 with bipolar disorder who completed ≥2 follow-up assessments (median follow-up length = 13.1 years) in the longitudinal Course and Outcome of Bipolar Youth (COBY) study were included. Suicide attempt over follow-up was assessed via the A-LIFE Self-Injurious/Suicidal Behavior scale. Predictors from the literature on suicidal behavior in bipolar disorder that are readily assessed in clinical practice were selected and trichotomized as appropriate (presence past 6 months/lifetime history only/no lifetime history)...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#24
JOURNAL ARTICLE
Lori L Altshuler, Trisha Suppes, David O Black, Willem A Nolen, Gabriele Leverich, Paul E Keck, Mark A Frye, Ralph Kupka, Susan L McElroy, Heinz Grunze, Christina M R Kitchen, Robert Post
OBJECTIVES: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. METHODS: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with bipolar II disorder, two with bipolar disorder not otherwise specified) were treated with one of three antidepressants as an adjunct to mood stabilizers. The patients' switch rates were assessed...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#25
JOURNAL ARTICLE
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Excess mortality is a critical hallmark of bipolar disorder (BD) due to co-occurring general medical disorders and especially from suicide. It is timely to review of the status of suicide in BD and to consider the possibility of limiting suicidal risk. METHODS: We carried out a semi-systematic review of recent research reports pertaining to suicide in BD. FINDINGS: Suicide risk in BD is greater than with most other psychiatric disorders...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#26
JOURNAL ARTICLE
Farhan Fancy, Nelson B Rodrigues, Joshua D Di Vincenzo, Edmond H Chau, Rickinder Sethi, Muhammad I Husain, Hartej Gill, Aniqa Tabassum, Andrea Mckenzie, Lee Phan, Roger S McIntyre, Joshua D Rosenblat
BACKGROUND: Clinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression. METHODS: This study was conducted in a community clinic in Mississauga, Ontario (Canadian Rapid Treatment Centre of Excellence; Braxia Health)...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#27
JOURNAL ARTICLE
Katherine E Burdick, Caitlin E Millett, Anastasia K Yocum, Cara M Altimus, Ole A Andreassen, Valerie Aubin, Raoul Belzeaux, Michael Berk, Joanna M Biernacka, Hilary P Blumberg, Anthony J Cleare, Claudia Diaz-Byrd, Caroline Dubertret, Bruno Etain, Lisa T Eyler, Brent P Forester, Janice M Fullerton, Mark A Frye, Sébastien Gard, Ophelia Godin, Emmanuel Haffen, Federica Klaus, Trine Vik Lagerberg, Marion Leboyer, Anabel Martinez-Aran, Susan McElroy, Philip B Mitchell, Emilie Olie, Phebe Olorunfemi, Christine Passerieux, Amy T Peters, Daniel L Pham, Mircea Polosan, Julia R Potter, Martha Sajatovic, Ludovic Samalin, Raymund Schwan, Megan Shanahan, Brisa Solé, Rebecca Strawbridge, Amanda L Stuart, Ivan Torres, Torrill Ueland, Eduard Vieta, Lana J Williams, Anna L Wrobel, Lakshmi N Yatham, Allan H Young, Andrew A Nierenberg, Melvin G McInnis
OBJECTIVES: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. METHODS: Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#28
REVIEW
Hamid Fatemisough, Azam Moradi, Mahboubeh Vahid Dastgerdi, Rouholah Fatemi
BACKGROUND: Various factors are involved in the initiation of drug abuse, such as genetic and social factors. Among the factors that can be mentioned in associated with the tendency to addiction in children is the role of family prediction. This study aimed to explore the relationship between parenting styles and addiction tendency in Iran. METHODS: We searched Persian database included Magiran, SID, IranDoc and Noormagz for articles from 2007- 2022 in Iran. Seven articles with 1734 subjects were ultimately included in the qualitative and quantitative syntheses...
January 2024: Iranian Journal of Public Health
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JOURNAL ARTICLE
Jia-Nan Chen, Xiao-Jia Yang, Meng Cong, Ling-Jie Zhu, Xia Wu, Li-Ting Wang, Lei Sha, Yan Yu, Qian-Ru He, Fei Ding, Hua Xian, Hai-Yan Shi
Brachial plexus injury (BPI) with motor neurons (MNs) damage still remain poor recovery in preclinical research and clinical therapy, while cell-based therapy approaches emerged as novel strategies. Previous work of rat skin precursor-derived Schwann cells (SKP-SCs) provided substantial foundation for repairing peripheral nerve injury (PNI). Given that, our present work focused on exploring the repair efficacy and possible mechanisms of SKP-SCs implantation on rat BPI combined with neurorrhaphy post-neurotomy...
December 2024: Regenerative Therapy
#30
JOURNAL ARTICLE
Sara V Carlini, Teresa Lanza di Scalea, Stephanie Trentacoste McNally, Janice Lester, Kristina M Deligiannidis
Premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS) refer to physical, cognitive, or affective symptoms that arise in the late luteal phase and remit with menses. The present work is a clinically focused scoping review of the last twenty years of research on treatment for these disorders. A search of key terms using the PubMed/Medline, the Cochrane Library, Embase, and Web of Science databases was performed, and 194 studies of adult women met initial inclusion criteria for review. Research studies concerning medications, pharmacological and non-pharmacological complementary and alternative medicine treatments, and surgical interventions with the most available evidence were appraised and summarized...
January 2024: Focus: Journal of Life Long Learning in Psychiatry
#31
JOURNAL ARTICLE
Chaitra Jairaj, Gertrude Seneviratne, Veerle Bergink, Iris E Sommer, Paola Dazzan
BACKGROUND: Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP is a discrete disorder on the bipolar disorder spectrum with a distinct treatment profile and prognosis. METHODS: We conducted a PubMed database search for various terms involving PPP and its treatment and included peer-reviewed articles published in English...
January 2024: Focus: Journal of Life Long Learning in Psychiatry
#32
JOURNAL ARTICLE
Chloe E Page, Brianna Soreth, Christina A Metcalf, Rachel L Johnson, Korrina A Duffy, Mary D Sammel, James Loughead, C Neill Epperson
OBJECTIVE: The menopause transition is associated with difficulties in executive function. However, it is unclear whether these difficulties persist past perimenopause. This study investigated whether potential confounders, including natural vs. surgical postmenopause and menopause-related psychological symptoms, influence whether executive dysfunction persists into postmenopause. STUDY DESIGN: A cross-sectional sample of women aged 35-65 years (N = 1971) in one of four groups, premenopause, perimenopause, natural postmenopause, and surgical postmenopause, were surveyed...
January 2024: Focus: Journal of Life Long Learning in Psychiatry
#33
JOURNAL ARTICLE
Anya Suppermpool, Declan G Lyons, Elizabeth Broom, Jason Rihel
Sleep is a nearly universal behaviour with unclear functions1 . The synaptic homeostasis hypothesis proposes that sleep is required to renormalize the increases in synaptic number and strength that occur during wakefulness2 . Some studies examining either large neuronal populations3 or small patches of dendrites4 have found evidence consistent with the synaptic homeostasis hypothesis, but whether sleep merely functions as a permissive state or actively promotes synaptic downregulation at the scale of whole neurons is unclear...
May 1, 2024: Nature
#34
JOURNAL ARTICLE
Joshua Jackson, Christian Hoffmann, Enzo Scifo, Han Wang, Lena Wischhof, Antonia Piazzesi, Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B Ryan, Hermann Döring, Jochen H M Prehn, Klemens Rottner, Gregory Giannone, Pierluigi Nicotera, Dan Ehninger, Dragomir Milovanovic, Daniele Bano
Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson's disease (PD). It has been well documented that the reversible liquid-liquid phase separation of α-Syn can modulate synaptic vesicle condensates at the presynaptic terminals. However, α-Syn can also form liquid-like droplets that may convert into amyloid-enriched hydrogels or fibrillar polymorphs under stressful conditions...
April 30, 2024: Cell Death & Disease
#35
JOURNAL ARTICLE
Gerald T Nepom
Failures in peripheral immune tolerance mechanisms create a permissive environment for autoimmune diabetes initiation and disease progression. Biomarker analyses provide tools that allow recognition of this loss of tolerance, reflecting a serial acquisition of pathogenic characteristics causally linked to islet β-cell dysfunction and death. Autoimmune effector cell activation and expansion, ineffective immune regulation, and tissue response to injury during active disease each represent challenges to homeostasis; however, they also represent targets for therapeutic intervention, with the potential for restoration of tolerance...
May 1, 2024: Cold Spring Harbor Perspectives in Medicine
#36
JOURNAL ARTICLE
Corey Commins, Margot Bolster, Linda Mulligan
UNLABELLED: The pattern of neck injuries sustained in fatal cases of external compression to the neck is recorded during Post Mortem Examinations (PME), to assist in the interpretation of the circumstances that led to death. In this study, the PMEs performed for 298 cases of hanging and strangulation occurring between 2016 and 2020 in Ireland were retrospectively reviewed for the purpose of recording and collating the external and internal neck injuries observed during each PME, as well as the toxicology results for each decedent...
April 28, 2024: Journal of Forensic and Legal Medicine
#37
JOURNAL ARTICLE
Luciana Massi, Carolyn Lewis, Skye Stewart, Diana Jans, Rupesh Gautam, Lina Jalloub, Anneka Bowman, Philippa Middleton, Sue Vlack, Frances M Boyle, Carrington Shepherd, Vicki Flenady, Deanna Stuart-Butler, Kym M Rae
The stillbirth rate among Aboriginal and Torres Strait Islander women and communities in Australia is around double that of non-Indigenous women. While the development of effective prevention strategies during pregnancy and improving care following stillbirth for women and families in communities has become a national priority, there has been limited progress in stillbirth disparities. With community permission, this study aimed to gain a better understanding of community experiences, perceptions, and priorities around stillbirth...
2024: Frontiers in Public Health
#38
JOURNAL ARTICLE
Qiu E Yang, Xiaodan Ma, Minchun Li, Mengshi Zhao, Lingshuang Zeng, Minzhen He, Hui Deng, Hanpeng Liao, Christopher Rensing, Ville-Petri Friman, Shungui Zhou, Timothy R Walsh
The horizontal transfer of plasmids has been recognized as one of the key drivers for the worldwide spread of antimicrobial resistance (AMR) across bacterial pathogens. However, knowledge remain limited about the contribution made by environmental stress on the evolution of bacterial AMR by modulating horizontal acquisition of AMR plasmids and other mobile genetic elements. Here we combined experimental evolution, whole genome sequencing, reverse genetic engineering, and transcriptomics to examine if the evolution of chromosomal AMR to triclosan (TCS) disinfectant has correlated effects on modulating bacterial pathogen (Klebsiella pneumoniae) permissiveness to AMR plasmids and phage susceptibility...
April 30, 2024: Nature Communications
#39
JOURNAL ARTICLE
Rahel Paloots, Michael Baudis
Cancer cell lines are an important component in biological and medical research, enabling studies of cellular mechanisms as well as the development and testing of pharmaceuticals. Genomic alterations in cancer cell lines are widely studied as models for oncogenetic events and are represented in a wide range of primary resources. We have created a comprehensive, curated knowledge resource-cancercelllines.org-with the aim to enable easy access to genomic profiling data in cancer cell lines, curated from a variety of resources and integrating both copy number and single nucleotide variants data...
April 30, 2024: Database: the Journal of Biological Databases and Curation
#40
REVIEW
Samuel Watts, John Coutsouvelis, Joanne Wickens, Susan Poole, Mia Percival, John R Zalcberg
A proportion of returned medications may potentially meet quality standards to be reused safely. In Australia, there is no regulatory guidance available to facilitate such medication reuse. This narrative review aimed to identify and review international literature describing medication reuse programs to provide insight into their implementation and potential barriers. Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) -based guidelines, a literature search was conducted in Medline, Scopus, and Embase using key words such as 'medication' and 'reuse' to identify relevant articles...
April 30, 2024: International Journal for Quality in Health Care
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