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forced oscillation technique

Emiri Miura, Naho Tsuchiya, Yu Igarashi, Ritsuko Arakawa, Etsuhiro Nikkuni, Tokiwa Tamai, Masao Tabata, Shinya Ohkouchi, Toshiya Irokawa, Hiromasa Ogawa, Takako Takai-Igarashi, Yoichi Suzuki, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto, Hajime Kurosawa
BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data...
February 12, 2019: Respiratory Investigation
Stephen Milne, Kanika Jetmalani, David G Chapman, Joseph M Duncan, Claude S Farah, Cindy Thamrin, Gregory G King
Respiratory system reactance (Xrs) measured by the forced oscillation technique (FOT) is theoretically and experimentally related to lung volume. In chronic obstructive pulmonary disease (COPD), the absolute volume measured by body plethysmography includes a proportion which is inaccessible to pressure oscillations applied via the mouth - that is, a 'non-communicating' lung volume. We hypothesized that, in COPD, the presence of non-communicating lung would disrupt the expected Xrs-volume relationship when compared to plethysmographic functional residual capacity (FRCpleth )...
February 14, 2019: Journal of Applied Physiology
Omur E Dagdeviren, Yoichi Miyahara, Aaron Mascaro, Peter Grütter
Atomic force microscopy (AFM) is an analytical surface characterization tool which can reveal a sample's topography with high spatial resolution while simultaneously probing tip-sample interactions. Local measurement of chemical properties with high-resolution has gained much popularity in recent years with advances in dynamic AFM methodologies. A calibration factor is required to convert the electrical readout to a mechanical oscillation amplitude in order to extract quantitative information about the surface...
January 2019: Review of Scientific Instruments
Franz J Giessibl
Atomic force microscopy (AFM) was introduced in 1986 and has since made its way into surface science, nanoscience, chemistry, biology, and material science as an imaging and manipulating tool with a rising number of applications. AFM can be employed in ambient and liquid environments as well as in vacuum and at low and ultralow temperatures. The technique is an offspring of scanning tunneling microscopy (STM), where the tunneling tip of the STM is replaced by using a force sensor with an attached tip. Measuring the tiny chemical forces that act between the tip and the sample is more difficult than measuring the tunneling current in STM...
January 2019: Review of Scientific Instruments
Kris Nilsen, Frank Thien, Cindy Thamrin, Matthew J Ellis, Gordon Kim Prisk, Gregory G King, Bruce R Thompson
De-recruitment of airspaces in the lung occurs when airways close during exhalation, and is related to ventilation heterogeneity and symptoms in asthma. The forced oscillation technique has been used to identify surrogate measures of airway closure via the reactance (Xrs) versus lung volume relationship. This study, used a new algorithm to identify de-recruitment from the Xrs versus lung volume relationship from a slow vital capacity maneuver. We aimed to compare two de-recruitment markers on the Xrs versus volume curve; the onset reduction of Xrs (DR1vol ) and onset of more rapid reduction of Xrs (DR2vol ), between control and asthmatic subjects...
January 31, 2019: Journal of Applied Physiology
Peng Jiang, Boyuan Huang, Liyu Wei, Fei Yan, Xiaowei Huang, Yuhao Li, Shuhong Xie, Kai Pan, Yunya Liu, Jiangyu Li
Collagen is the main protein in extracellular matrix that is found in many connective tissues, and it exhibits piezoelectricity that is expected to correlate with its hierarchical microstructure. Resolving fine electromechanical structure of collagen, however, is challenging, due to its weak piezoresponse, rough topography, and microstructural hierarchy. Here we adopt the newly developed sequential excitation (SE) strategy in combination with piezoresponse force microscopy (PFM) to overcome these difficulties...
January 30, 2019: Nanotechnology
Lisa M Wilson, Lisa Morrison, Karen A Robinson
BACKGROUND: Cystic fibrosis is a life-limiting genetic condition in which thick mucus builds up in the lungs, leading to infections, inflammation, and eventually, deterioration in lung function. To clear their lungs of mucus, people with cystic fibrosis perform airway clearance techniques daily. There are various airway clearance techniques, which differ in terms of the need for assistance or equipment, and cost. OBJECTIVES: To summarise the evidence from Cochrane Reviews on the effectiveness and safety of various airway clearance techniques in people with cystic fibrosis...
January 24, 2019: Cochrane Database of Systematic Reviews
Kanokporn Udomittipong, Jurairut Triwatanawong, Akarin Nimmannit, Chulaluk Komoltri
BACKGROUND: Forced oscillation technique (FOT) requires minimal patient cooperation and is particularly useful in young children. Bronchodilator test is a valuable tool for wheezy and asthmatic patients. The cut-off value for bronchodilator response by FOT in healthy Thai children has not been reported. OBJECTIVE: To determine the cut-off values for positive bronchodilator response in healthy Thai preschool children using pseudorandom FOT. METHODS: FOT was used to measure respiratory function at baseline and after 400 mcg MDI salbutamol in healthy Thai children aged 3-6 years...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Xiaohe K Xu, Brian P Harvey, Kenneth R Lutchen, Brian D Gelbman, Stephen L Monfre, Robert E Coifman, Charles E Forbes
Purpose: This study supports the use of thin-film micro-electro-mechanical system (MEMS) airflow sensors in the forced oscillation technique. Materials and methods: The study employed static testing using air flow standards and computer-controlled sound attenuations at 8 Hz. Human feasibility studies were conducted with a testing apparatus consisting of a pneumotach and thin-film MEMS air flow sensors in series. Short-time Fourier transform spectra were obtained using SIGVIEW software...
2018: Medical Devices: Evidence and Research
Yoshitaka Isobe, Satoru Ito, Toshiaki Matsuda, Shingo Iwano, Akemi Uchida, Nobunori Takahashi, Toshihisa Kojima, Keiko Wakahara, Etsuro Yamaguchi, Yoshinori Hasegawa
The aim of this study was to examine long-term changes in pulmonary function and respiratory impedance (Zrs) as assessed by forced oscillation technique (FOT) of rheumatoid arthritis (RA)-related pulmonary disorders. Data of 42 RA patients who underwent pulmonary function tests and Zrs measurements at least twice at a >900-day interval were retrospectively reviewed. Zrs, respiratory resistance (Rrs) and reactance (Xrs), were measured as a function of oscillatory frequency from 4 to 36 Hz. The Rrs and difference between inspiratory and expiratory phases of Xrs were significantly decreased...
December 21, 2018: Respiratory Physiology & Neurobiology
Yoo Jin Oh, Melanie Koehler, Yoonhee Lee, Sourav Mishra, Joon Won Park, Peter Hinterdorfer
Reliable quantification of binding affinity is important in biotechnology and pharmacology, and increasingly coupled with a demand for ultra-sensitivity, nano-scale resolution, and minute sample amounts. Standard techniques are not able to meet these criteria. This study provides a new platform based on atomic force microscopy (AFM) derived recognition imaging to determine affinity by visualizing single molecular bindings on nano-sized dendrons. Using DNA hybridization as a demonstrator, an AFM sensor adorned with a cognate binding strand senses and localizes target DNAs at nanometer resolution...
December 18, 2018: Nano Letters
Gary W Hoyle, Connie F Schlueter, Sadiatu Musah
Nanoparticles possess a number of useful properties that make them useful for a variety of industrial and commercial applications. The small size of nanoparticles means that they are respirable and can penetrate deep into the lung when inhaled. Because of this, there is interest in assessing possible toxic effects of nanoparticles on the respiratory system. Measurement of respiratory mechanics and pulmonary function represents a sensitive way of detecting pathological effects of inhaled substances on the lungs...
2019: Methods in Molecular Biology
Tatiana Drevytska, Roman Morhachov, Lesya Tumanovska, Georgiy Portnichenko, Vasyl Nagibin, Oleksiy Boldyriev, Tatiana Lapikova-Bryhinska, Veronika Gurianova, Borys Dons'koi, Maxim Freidin, Vladimir Ivanisenko, Elena Yu Bragina, Ralf Hofestädt, Victor Dosenko
One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma. Rats were randomly divided into three groups: control group, OVA-induced asthma group; OVA-induced asthma + IL10 shRNA interference group. Target gene (IL10) was predicted by ANDSystem. We have demonstrated that RNA-interference of IL10 affected cardiovascular (tested using Millar microcatheter system) as well as respiratory functions (tested using force-oscillation technique, Flexivent) in rats...
December 10, 2018: Journal of Integrative Bioinformatics
Pinyapa Mukdjindapa, Wiparat Manuyakorn, Potjanee Kiewngam, Cherapat Sasisakulporn, Pisut Pongchaikul, Wasu Kamchaisatian, Suwat Benjaponpitak
BACKGROUND: The reference values of Forced Oscillation Technique (FOT) parameters of the inspiratory and expiratory phase for preschool children have not yet been established. OBJECTIVE: To evaluate FOT measures in Thai healthy preschool children. METHODS: Preschool children, aged 3-6 years, were screened. Children who were positive for the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for asthma, positive family history of allergic diseases, recent lower respiratory tract infections, and environmental tobacco smoke were excluded...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Behrouz Mostafavi, Sandra Diaz, Eeva Piitulainen, Berend C Stoel, Per Wollmer, Hanan A Tanash
Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to emphysema. A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was identified by the Swedish national neonatal AAT screening program in 1972-1974 and has been followed-up since birth. Our aim was to study whether the cohort has signs of emphysema in pulmonary function tests (PFTs) and computed tomography (CT) densitometry at 38 years of age in comparison with an age-matched control group, randomly selected from the population registry...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Ryan P Butzko, Anays M Sotolongo, Drew A Helmer, Jacquelyn C Klein-Adams, Omowunmi Y Osinubi, Andrew R Berman, Ronaldo Ortiz-Pacheco, Michael J Falvo
PURPOSE: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. METHODS: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV1 /FVC, FEV1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal...
November 30, 2018: Respiratory Physiology & Neurobiology
Gene T Yocum, Jose F Perez-Zoghbi, Jennifer Danielsson, Aisha S Kuforiji, Yi Zhang, Guanguan Li, M S Rashid Roni, Revathi Kodali, Douglas C Stafford, Leggy A Arnold, James M Cook, Charles W Emala
Airway smooth muscle cells express GABAA receptors, and previous reports have demonstrated that GABAA receptor activators relax airway smooth muscle. However, given the activity of GABAA receptors in central nervous system inhibitory neurotransmission, concern exists that these activators may lead to undesirable sedation. MIDD0301 is a novel imidazobenzodiazepine and positive allosteric modulator of the GABAA receptor with limited brain distribution, thus eliminating the potential for sedation. Here we demonstrate that MIDD0301 relaxes histamine-contracted guinea pig (p<0...
November 29, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Diane M Gray, Dorottya Czovek, Lauren McMillan, Lidija Turkovic, Jacob A M Stadler, Anessa Vanker, Bence L Radics, Zoltan Gingl, Graham L Hall, Peter D Sly, Heather J Zar, Zoltán Hantos
RATIONALE: Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and non-invasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. OBJECTIVE: To investigate whether lung function derived from the intra-breath forced oscillation technique (FOT), was able to identify healthy infants at risk of LRTI in the first year. METHODS AND MEASUREMENTS: Lung function was measured with the novel intra-breath FOT, in six-week infants in a South African birth cohort (Drakenstein Child Health Study)...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Genny Raffaeli, Chiara Veneroni, Stefano Ghirardello, Anna Lavizzari, Sofia Passera, Fabio Mosca, Giacomo Cavallaro, Raffaele L Dellacà
Respiratory management during extracorporeal membrane oxygenation (ECMO) is complex. Assessment of lung mechanics might support a patient-tailored ventilatory strategy. We report, for the first time, the use of the forced oscillation technique (FOT) to evaluate lung function during neonatal ECMO to improve the individualization of respiratory support. The patient was a formerly preterm infant at a corrected age of 40 weeks (gestational age 32 weeks) undergoing veno-arterial ECMO for refractory respiratory failure secondary to influenza A (H1N1) pneumonia...
2018: Frontiers in Pediatrics
Mattia Iannella, Paola D'Alessandro, Maurizio Biondi
The so-called glacial refugia, formed during the Pleistocene climatic oscillations, played a major role in shaping the distribution of European species, triggering migrations or isolating populations. Many of these events were recently investigated by genetic data, mainly for the European Last Glacial stage, in the Iberic, Italian and Greek-Balkan peninsulas. The amphibian genus Salamandrina, the most ancient living salamandrid lineage, was widespread in Europe until the climatic oscillations of Miocene probably forced it to shelter in the only suitable territory at that time, the Apennines...
November 7, 2018: Scientific Reports
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