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Wang Zhang, Yuntao Zhang, Yuxian He, Xiying Wang, Qiang Fang
Macrophages are dynamic cells whose phenotypes and functions are regulated by surrounding inflammatory mediators after pathogenic infection. Imbalanced polarization of classically activated (M1) and alternatively activated (M2) macrophages is closely associated with infection-related complications and their severity. The pathway of T-cell immunoglobulin mucin 3 (Tim-3) / galectin-9 (Gal-9) plays an important role in infection by regulating macrophage function. However, the effects of Tim-3/Gal-9 signalling on M1/M2 macrophage polarization are unclear...
February 11, 2019: Experimental Cell Research
Mohammad Najarian, Gino J Lim
By providing objective measures, resilience metrics (RMs) help planners, designers, and decisionmakers to have a grasp of the resilience status of a system. Conceptual frameworks establish a sound basis for RM development. However, a significant challenge that has yet to be addressed is the assessment of the validity of RMs, whether they reflect all abilities of a resilient system, and whether or not they overrate/underrate these abilities. This article covers this gap by introducing a methodology that can show the validity of an RM against its conceptual framework...
February 14, 2019: Risk Analysis: An Official Publication of the Society for Risk Analysis
Norikazu Sato, Jiafeng Yao, Daisuke Kawashima, Masahiro Takei
Enhancement of positive dielectrophoresis (pDEP) particle trapping by a co-occurring fluid flow under an AC electric field in an electrode-multilayered microfluidic device is investigated by three-dimensional particle-fluid flow simulations. The particle motion near one cross-section of the microfluidic device is simulated under a zero flow condition by the Eulerian- Lagrangian method incorporating the AC electrothermal effect, thermal buoyancy and dielectrophoresis. The mean trapping rate under the steady state Rm is evaluated from the simulated number of trapped particles Nt rap for 54 cases with four parameters: electrode excitation pattern, medium conductivity σ, applied voltage ϕe and the real part of the Clausius-Mossotti factor Re[K( ω)]...
February 12, 2019: IEEE Transactions on Bio-medical Engineering
Hala S Abdel-Ghaffar, Hamdy A Youseff, Fatma A Abdelal, Mohamed A Osman, Jehan A Sayed, Mohamed Amir Fathy Riad, Marwa M Abdel-Rady
BACKGROUND: Effects of intraoperative recruitment maneuvers (RMs) on oxygenation and pulmonary compliance are lost during recovery if high inspired oxygen and airway suctioning are used. We investigated the effect of post-extubation noninvasive CPAP mask application on the alveolar arterial oxygen difference [(A-a) DO2 ] after pediatric laparoscopic surgery. METHODS: Sixty patients (1-6 years) were randomly allocated to three groups of 20 patients, to receive zero end-expiratory pressure (ZEEP group), RM with decremental PEEP titration only (RM group), or followed with post-extubation CPAP for 5 minutes (RM-CPAP group)...
February 14, 2019: Acta Anaesthesiologica Scandinavica
Mingkui Zhou, Michael Humbert, Muhammad M Mukhtar, Hanna B Scinto, Hemant K Vyas, Samir K Lakhashe, Siddappa N Byrareddy, Gregor Maurer, Swati Thorat, Joshua Owuor, Zhao Lai, Yidong Chen, Anthony Griffiths, Agnès-Laurence Chenine, Sanjeev Gumber, François Villinger, David Montefiori, Ruth M Ruprecht
Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. HIV-1 clade A (HIV-A) predominates in parts of Africa. We constructed an R5 clade A SHIV (SHIV-A; strain SHIV-KNH1144) carrying env from a Kenyan HIV-A. SHIV-A underwent rapid serial passage through six RMs. To allow unbridled replication without adaptive immunity, we simultaneously ablated CD8+ and B cells with cytotoxic monoclonal antibodies in the next RM, resulting in extremely high viremia and CD4+ T-cell loss...
February 13, 2019: Journal of Virology
Nicholas J Lobb, AuraLea C Fain, Kayla D Seymore, Tyler N Brown
This study quantified leg stiffness and vGRF measures for males and females using different stride lengths to run with four body borne loads (20, 25, 30, and 35 kg). Thirty-six participants (20 males and 16 females) ran at 4.0 m/s using either: their preferred stride length (PSL), or strides 15% longer (LSL) and shorter (SSL) than PSL. Leg stiffness and vGRF measures, including peak vGRF, impact peak and loading rate, were submitted to a RM ANOVA to test the main effect and interactions of load, stride length, and sex...
February 2, 2019: Journal of Biomechanics
Anna Sarnelli, Maria Luisa Belli, Valentina Di Iorio, Emilio Mezzenga, Monica Celli, Stefano Severi, Elisa Tardelli, Silvia Nicolini, Devil Oboldi, Licia Uccelli, Corrado Cittanti, Manuela Monti, Mahila Ferrari, Giovanni Paganelli
Radio-ligand therapy (RLT) with177 Lu-PSMA-617 is a promising option for patients with metastatic castration-resistant prostate-cancer (mCRPC). A prospective phase-II study (EUDRACT/RSO,2016-002732-32) on mCRPC is ongoing at IRST (Meldola, Italy). A total of 9 patients (median age: 68 y, range: 53⁻85) were enrolled for dosimetry evaluation of parotid glands (PGs), kidneys, red marrow (RM) and whole body (WB). Folic polyglutamate tablets were orally administered as PGs protectors and 500 mL of a 10% mannitol solution was intravenously infused to reduce kidney uptake...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Qingqing Dai, Shujuan Li, Ting Liu, Jiayin Zheng, Song Han, Aijuan Qu, Junfa Li
We previously reported that astrocytes are the main sources of interleukin (IL)-17A production that could aggravate neuronal injuries in ischemic stroke. However, the effects of IL-17A on ischemic astrocytes themselves and the underlying molecular mechanism are still unclear. In this study, we found that recombinant mouse (rm) IL-17A could significantly (P < 0.05 or <0.001) alleviate 1-hour oxygen-glucose deprivation (OGD)/reoxygenation (R) 24-hour-induced ischemic injuries in cortical astrocytes with a dose-dependent manner (n = 6 per group)...
February 11, 2019: Journal of Cellular Biochemistry
Xin-Ru Li, Yue Li, Wei Wang, Ning He, Xiao-Ling Tan, Xue-Qing Yang
Lambda-cyhalothrin has long been recommended as an effective insecticide to control the oriental armyworm, Mythimna separata (Walker), a notorious migratory pest of agricultural plants. Previous researches have suggested that survival, development, and reproduction of insects are influenced by sublethal concentrations of insecticides. However, the effects of sublethal concentrations of lambda-cyhalothrin on M. separata are less known. In this study, we determined the toxicity and effects of LC20 and LC50 concentration of lambda-cyhalothrin on development and reproduction of M...
January 2019: Pesticide Biochemistry and Physiology
Lisa W S Leung, Abdul Roudsari, Alex Kuo, Karen L Courtney
This methodological paper describes how system dynamics was applied in evaluating the effect of remote monitoring (RM) of cardiovascular implantable electronic device (CIED) workload on clinical resource utilization. The development of a causal loop diagram and a stock and flow diagram and the construction of the simulation model for comparison of an in-person clinic group and RM clinic group are described.
2019: Studies in Health Technology and Informatics
Hua Wang, Donglan Yuan, Saili Wang, Li Luo, Yu Zhang, Jun Ye, Kuichun Zhu
OBJECTIVE: Recurrent miscarriage (RM) affects about 5% of pregnancies. Etiology of 30-50% RM cases remains unknown. Advanced highly sensitive detection and analysis methods may help solve some of the cases. METHODS: Products of conception from 1155 RM cases were analyzed using classic karyotyping. Some cases without abnormal findings were subjected to next generation DNA sequencing (NGS) and chromosome copy number variation (CNV) analysis. RESULTS: Classic karyotyping identified abnormalities in 56...
February 10, 2019: Journal of Maternal-fetal & Neonatal Medicine
Yuko Tada, Shahriar Heidary, Atsushi Tachibana, Junaid Zaman, Evgenios Neofytou, Rajesh Dash, Joseph C Wu, Phillip C Yang
BACKGROUND: Manganese-enhanced MRI (MEMRI) detects viable cardiomyocytes based on the intracellular manganese uptake via L-type calcium-channels. This study aimed to quantify myocardial viability based on manganese uptake by viable myocardium in the infarct core (IC), peri-infarct region (PIR) and remote myocardium (RM) using T1 mapping before and after MEMRI and assess their association with cardiac function and arrhythmogenesis. METHODS: Fifteen female swine had a 60-minute balloon ischemia-reperfusion injury in the LAD...
January 31, 2019: International Journal of Cardiology
Jing Li, Jing-Ren Zhang
Streptococcus pneumoniae undergoes phase variation or spontaneous, reversible phenotypic variation in colony opacity, encapsulation, and pilus expression. The variation in colony opacity appears to occur in all strains, whereas the switches in the production of the capsule and pilus have been observed in several strains. This chapter elaborates on the variation in colony opacity since this phenomenon has been extensively characterized. S. pneumoniae produces opaque and transparent colonies on the translucent agar medium...
January 2019: Microbiology Spectrum
Aline Ms Farias, Simone Appenzeller, Marcondes C França, Alberto Rm Martinez, Elba E Etchebehere, Thiago F Souza, Allan O Santos
OBJECTIVE: Machado-Joseph disease (MJD) is a spinocerebellar ataxia, and osteoporosis is a multifactor disease that may affect patients with neurologic conditions. The frequency of osteoporosis among MJD patients, however, has not been studied. The purpose of this study is to evaluate bone mineral density (BMD) and identify correlations between clinical factors and frequency of vertebral fractures in patients with MJD. METHODS: Clinical data, lumbar X-rays and BMD data were obtained in 30 patients with MJD...
January 2019: Journal of Movement Disorders
Kexian Chen, Ling Feng, Shuyi Feng, Yuhua Yan, Zhen Ge, Zuguang Li, Zhongxiu Chen
The comprehensive mechanistic understanding of pungency and the binding interactions between pungent capsaicinoids from foods and their receptors have attracted increasing attention in food sensory and pharmaceutical fields. In this study, linear and quadratic statistically significant quantitative structure-pungency correlations have firstly been established for capsaicinoids by combining genetic function approximation and brute force approach and subsequently validated by the tests of cross validation, randomization, external prediction, Roy's rm 2 metrics and Golbraikh-Tropsha's criteria...
June 15, 2019: Food Chemistry
Hong Xiao, Yanan Zhao, Liu Liu, Minqin Xiao, Wei Qiu, Yin Liu
Multiple patientreported outcome measures (PROMs) are available to assess patient satisfaction after rhinoplasty. These selfassessment measures can be divided into 3 categories: measures for functional outcomes, aesthetic outcomes, and both. Although Barone et al have discussed this classification, a recently developed scale was not featured. We performed a PubMed search for publications in English that described patient satisfaction post-rhinoplasty, using PROMs that facilitate both functional and aesthetic selfassessment...
February 5, 2019: Aesthetic Surgery Journal
Sayantika Bhowal, Shreemoyee Ganguly, Indra Dasgupta
In the present paper, we have carried out a comparative first principles as well as model Hamiltonian study to understand novel magnetism in 6H perovskite iridates Ba$_3$IrTi$_2$O$_9$ and Ba$_3$TiIr$_2$O$_9$ resulting from an unusual combination of geometrical as well as exchange frustration owing to their unique crystal geometry. Our model calculations corroborated with multipolar analysis provides a comprehensive understanding of the spin-orbit entangled $j_{\rm eff}$~=~1/2 pseudo-spin states in both the materials...
February 5, 2019: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Jun Han, Zhen-Li Li, Hao Xing, Han Wu, Peng Zhu, Wan Yee Lau, Ya-Hao Zhou, Wei-Min Gu, Hong Wang, Ting-Hao Chen, Yong-Yi Zeng, Meng-Chao Wu, Feng Shen, Tian Yang
BACKGROUND: The resection margin (RM) status and microscopic vascular invasion (MVI) are known prognostic factors for hepatocellular carcinoma (HCC). An enhanced understanding of their impact on long-term prognosis is required to improve oncological outcomes. METHODS: Using multi-institutional data, the different impact of the RM status (narrow, <1 cm, or wide, ≥1 cm) and MVI (positive or negative) on overall survival (OS) and recurrence-free survival (RFS) after curative liver resection of solitary HCC without macrovascular invasion was analyzed...
February 1, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Moniek H C Craenmehr, Iris Nederlof, Milo Cao, Jos J M Drabbels, Marijke J Spruyt-Gerritse, Jacqueline D H Anholts, Hanneke M Kapsenberg, Janine A Stegehuis, Carin van der Keur, Esther Fasse, Geert W Haasnoot, Marie-Louise P van der Hoorn, Frans H J Claas, Sebastiaan Heidt, Michael Eikmans
Human leukocyte antigen (HLA)-G is an immune modulating molecule that is present on fetal extravillous trophoblasts at the fetal-maternal interface. Single nucleotide polymorphisms (SNPs) in the 3 prime untranslated region (3'UTR) of the HLA-G gene can affect the level of HLA-G expression, which may be altered in women with recurrent miscarriages (RM). This case-control study included 23 women with a medical history of three or more consecutive miscarriages who delivered a child after uncomplicated pregnancy, and 46 controls with uncomplicated pregnancy...
February 1, 2019: International Journal of Molecular Sciences
Tony Varghese, M C Prashant, Kiran Dodani, Neelu Nagpal, Neha Khare, Vikram Singh
AIM: To assess and compare the impact of non-surgical periodontal therapy on plasma reactive oxygen metabolites and resistin values in chronic periodontitis obese and non-obese patients. MATERIALS AND METHODS: Total 200 subjects were included in the present study and were broadly divided into two study groups with 100 patients in each group as follows: group A: Obese patients with chronic periodontitis, group B: Non-obese, normal weight patients with chronic periodontitis...
December 1, 2018: Journal of Contemporary Dental Practice
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