When Good Go Bad

BACKGROUND: Several studies deal with the question of what constitutes a "satisfactory death". A smaller number of studies deal with unsatisfactory dying processes. And only a few shed light on unsatisfactory deaths that take place in hospices and palliative care units, which see themselves as places conducive to a "good" death. What also remains largely undiscussed are the ethical aspects that accompany the observation of an unsatisfactory course of death. METHOD: The research was carried out as an exploratory and qualitative study...

INTRODUCTION: This study follows recent calls to explore the emotional foundations of routine development. Routine development forms a nexus between stability and change and is thus crucial for studying organizational decision-making and organizational change. Individuals and teams going through organizational change often experience sadness and fear. METHODS: We conducted a laboratory experiment with 84 teams to study the effect of sadness and fear on routine development...

Critics of medical aid in dying (MAID) often argue that it is impermissible because background social conditions are insufficiently good for some persons who would utilize it. I provide a critical evaluation of this view. I suggest that receiving MAID is a sort of "hard choice," in that death is prima facie bad for the individual and only promotes that person's interests in special circumstances. Those raising this objection to MAID are, I argue, concerned primarily about the effects of injustice on hard choices...

In the trust-health relationship, how trusting other people in society may promote good health is a topic often examined. However, the other direction of influence-how health may affect trust-has not been well explored. In order to investigate this possible effect, we employed the Bayesian Mindsponge Framework (BMF) analytics to go deeper into the information processing mechanisms underlying the expressions of trust. Conducting a Bayesian analysis on a dataset of 1237 residents from Cali, Colombia, we found that general health status is positively associated with generalized trust, but recent experiences of illnesses/injuries have a negative moderating effect...

As the Roman philosopher Lucretius asked, why do we fear and regret death, but do not regret not having been born earlier, when death and prenatal nonexistence are mirror images? Both deprive us of goods we might have had, and this deprivation most plausibly explains the badness of death. This paper first considers and rejects explanations other than the deprivation of goods. It then suggests an explanation in terms of a state of which death deprives us, and which is itself asymmetrical in regard to the future and the past...

BACKGROUND: When older nursing home residents and their families are faced with end-of-life care decisions in Taiwan, they make them in the context of traditional cultural norms and socioeconomic changes. Both parties (residents and their family members) are often unwilling to broach the topic, leading to a decisional impasse. The aim of this study was to understand difficult-to-raise issues related to end-of-life care by investigating the perspectives of older nursing home residents and their family members...

Basic principle: There exists a rare aggressive neoplasm called esophageal rhabdomyosarcoma. It originates in cells of the striated muscle or mesenchymal cells which differ from the striated muscle. This tumor has a high degree of malignancy and extensive metastasis. Masses of the sick people are at a high phase when going to hospital. Consequently, the prognosis is exceedingly bad. Patient concerns: A 54-year-old male presented with dysphagia as the initial symptom...

When human adults make decisions (e.g., wearing a seat belt), we often consider the negative consequences that would ensue if our actions were to fail, even if we have never experienced such a failure. Do the same considerations guide our understanding of other people's decisions? In this paper, we investigated whether adults, who have many years of experience making such decisions, and 6- and 7-year-old children, who have less experience and are demonstrably worse at judging the consequences of their own actions, conceive others' actions as motivated both by reward (how good reaching one's intended goal would be), and by what we call "danger" (how badly one's action could end)...

Background: Older patients from nursing homes are commonly exposed to polypharmacy before a hospital admission. Deprescribing has been promoted as a solution to this problem, though systematic reviews have not found benefit. The aim of this study was to understand if in-hospital deprescribing of certain classes of medications is associated with certain benefits or risks. Methods: We conducted a prospective, multicentre, cohort study in 239 medical inpatients ⩾75 years (mean age 87...

The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive molecular machines to coordinate diverse cellular processes. Due to its many roles during both interphase and mitosis, maintaining centrosome homeostasis is essential to normal health and development. Centrosome instability, divergence from normal centrosome number and structure, is a common pathognomonic cellular state tightly associated with cancers and other genetic diseases. As novel connections are investigated linking the centrosome to disease, it is critical to understand the breadth of centrosome functions to inspire discovery...

Mitochondrial sequences were among the first molecular data collected for phylogenetic studies and they plentiful in DNA sequence archives. However, the future value of mitogenomic data in phylogenetics is uncertain, because its phylogenetic signal sometimes conflicts with that of the nuclear genome. A thorough understanding of the causes and prevalence of cyto-nuclear discordance would aid in reconciling different results owing to sequence data type, and provide a framework for interpreting megaphylogenies when taxa which lack substantial nuclear data are placed using mitochondrial data...

BACKGROUND: Blue wavelengths are thought to have an effect on circadian rhythms. Using a smartphone, which emits a 453 nm blue light, can worsen the quality of sleep. AIMS: To study the skin changes caused by poor sleep quality induced by smartphone usage. METHODS: The participants were 22 Korean women aged 20-39 years, with no sleep problems and a Pittsburgh Sleep Quality Index (PSQI) score of <5. The participants used a smartphone for 2 h before normal sleep hours...

Background: Dementia care is one of the most rapidly growing areas in health care. Despite this, relatively little is known about the experiences of persons with dementia in relation to quality of care. Objective: The aim of this study was to describe how persons with dementia in nursing homes experience the quality of care. Design: A cross-sectional design was used. Setting and Participants: The study was conducted in a nursing home in Norway...

BACKGROUND: We study the significance of stories about bad trips among users of psychedelics. Drawing on narrative theory, we describe the characteristics of such stories and explore the work they do. METHODS: In-depth qualitative interviews with 50 Norwegian users of psychedelics. RESULTS: Almost all participants had frightening experiences when using psychedelics and many described these as bad trips. The key feature of a bad trip was a feeling of losing oneself or going crazy, or ego dissolution...

Apart from being considered a potential threat to ecosystems and human health, the ubiquity of microplastics presents analytical challenges. There is a high risk of sample contamination during sampling, sample preparation and analysis. In this study, the potential of sample contamination or misinterpretation due to substances associated to disposable laboratory gloves or reagents used during sample preparation, was investigated. Leachates of ten different types of disposable gloves were analysed using Raman microspectroscopy (µ-Raman), Fourier-transform infrared microspectroscopy (µ-FTIR) and pyrolysis-gas chromatography/mass spectrometry (pyr GC/MS)...

This article covers the key steps and decisions that we make when performing a 1st-stage revision Total Knee Arthroplasty (TKA) at the Avon Orthopaedic Centre and includes more detailed technique and tips regarding how we make our spacers. The first stage of a two-stage protocol should be done in a stable patient with information about the organism, and with the option of plastic surgery flap coverage if required. It should ideally be performed in the unit that is going to perform the second stage, and the operation note should document the soft-tissues, bone loss and extensor mechanism issues that will influence planning for the second stage...

Background: Malaria remains a public health issue in the world especially in resource-limited countries, where it has a negative impact on their economy. There is a body of recent reports outlining the crucial role of enterprises in control of malaria. The present study aimed at determining the knowledge, attitudes, and practices (KAP) towards malaria among employees from enterprises in the town of Douala, Cameroon. Methods: A cross-sectional descriptive study took place between February 2015 and June 2017 in 14 enterprises of Douala...

Extraordinary actions have been implemented in an effort to control the rapid spread of the ongoing COVID-19 epidemic in Egypt. People's adherence to control measures is influenced by their knowledge, attitudes and practices towards the disease. Therefore, in the present study we assessed pharmacy senior students' knowledge, attitudes and practices towards the COVID-19 pandemic. An online questionnaire was created and it consisted of 12 questions testing their knowledge about COVID-19 clinical characteristics, transmission routes and prevention and control steps...

AIMS: To describe lived experiences of spirituality from the perspective of people who have been subject to inpatient psychiatric care and to interpret these experiences from an understanding of health as dialectical. METHODS: After approval from a regional ethical board, eleven participants were recruited from two organisations for people with mental health problems. Participants were asked to narrate about spiritual experiences and occasions where such experiences had come close...

Theta-band (4-12 Hz) activities in the frontal cortex have been thought to be a key mechanism of sustained attention and goal-related behaviors, forming a phase-coherent network with task-related sensory cortices for integrated neuronal ensembles. However, recent visual task studies found that selective attention attenuates stimulus-related theta power in the visual cortex, suggesting a functional dissociation of cortical theta oscillations. To investigate this contradictory behavior of cortical theta, a visual Go/No-Go task was performed with electroencephalogram recording in C57BL/6J mice...