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cardiovacular disease

Jui-Peng Tsai, Richard Kuo, Jing-Yi Sun, Chun-Ho Yun, Kuo-Tze Sung, Chuan-Chuan Liu, Jen-Yuan Kuo, Chung-Lieh Hung, Tung-Hsin Wu, Jiun-Lu Lin, Ta-Chuan Hung, Chia-Yuan Liu, Charles Jia-Yin Hou, Hung-I Yeh, Hiram G Bezerra
Thoracic aortic calcification (TAC) is tightly linked to pathological atherosclerosis and associated with certain cardiovascular diseases. While diabetes mellitus (DM) is known as a coronary heart disease equivalent, we examined the presence of TAC across the dysglycemic spectrum of diabetes mellitus (DM). We consecutively studied 3003 asymptomatic ethnic Asians underwent annual cardiovacular health survey, and further categorized them into: 1) 1760 normo-glycemic, 2) 968 pre-diabetic, and 3) 274 overt DM based on dysglycemic indices and medical histories...
2019: PloS One
Dragan Lovic, Andreas Pittaras, Manolis Kallistratos, Constantinos Tsioufis, Charalampos Grassos, Dragan Djordjevic, Ivan Tasic, Athanasios Manolis
BACKGROUND: The impact of overt diabetes and poor glycemic control on the risk of cardiovascular disease is well established. Among patients with type 2 diabetes, several studies demonstrated a significant increase in coronary artery disease-related death and cardiovascular events associated with HbA1c levels of greater than 7% compared with lower levels. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a novel class of anti-diabetic drugs that lower blood glucose levels through the suppression of renal glucose reabsorption thereby promoting renal glucose excretion...
2018: Cardiovascular & Hematological Disorders Drug Targets
Paolo Giovanardi, Enrico Tincani, Guglielmo Stefanelli, Fabrizio Turrini, Paolo Magnavacchi, Stefania Sansoni, Mauro Zennaro, Giovanni Pinelli, Stefano Tondi
BACKGROUND: Right ventricular (RV) function is difficult to be measured but plays a role in morbility and mortality of patients with cardiopulmonary diseases, so many echocardiographic parameters have been developed from M-mode, B-mode and Doppler tissue imaging (DTI) evaluation. Right ventricular presystolic peak velocity (RVPrP) measured with DTI of the tricuspidal annulus and its changes in RV dysfunction have never been assessed in a patient's cohort of stable patients with cardiovascular risk factors...
April 2017: Minerva Cardioangiologica
Leona Procházková, Miroslav Souček
Periodontitis (PD) is one of the most common infectious diseases of dental attachment. From epidemiological studies there is known association of periodontitis with chronic diseases as for example diabetes mellitus, cardiovacular diseases, atherosclerosis or Crohn disease. In last decade there is an increasing evidence for association of rheumatoid arthritis (RA) and periodontitis also. RA and PD have some common genetic, environmental and immunopathological characters. Important aspect of reciprocal relationship is also ability to citrullination, which is innate to one of most important oral patogen - Porphyromonas gingivalis...
February 2014: Vnitr̆ní Lékar̆ství
Marc Foretz, Benoit Viollet
Metformin is currently the drug of first choice for the treatment of type 2 diabetes. However, although prescribed since the end of the 1950s, the mechanism of action of metformin remains as yet incompletely understood but recent work has unveiled novel and surprising properties. Epidemiological reports have suggested that metformin protects against heart failure and has antitumor properties independent of its anti-hyperglycemic effect. Here, we review the proposed mechanisms for metformin action in diabetes, cardiovacular diseases and cancer...
January 2014: Médecine Sciences: M/S
Andreas D Kistler
Diabetic Nephropathy is the most common cause of end stage renal disease in Western countries. An increased urinary albumin excretion represents a characteristic sign of diabetic kidney damage. Regular screening for microalbuminuria allows early detection and timely intervention. In overt diabetic nephropathy, quantification of albuminuria helps monitoring disease progression. Therapeutic interventions to reduce albuminuria retard progression of nephropathy and reduce cardiovacular mortality, since albuminuria represents an independent cardiovascular risk factor...
October 2, 2013: Praxis
Jerzy Wiliński, Mikołaj Dabrowski
BACKGROUND: The execution of the dosing regimen in Polish primary health care is unknown. The aim of the study was to appraise the medication adherence in patients with hypertension of various cardiovascular risk. MATERIAL AND METHODS: A prospective interviewer questionnaire-based study included 1,467 consecutive patients with arterial hypertension with the pharmacotherapy containing ramipril in the daily dose of 10 mg. The mean observation period was 30.3 +/- 7...
2013: Przegla̧d Lekarski
Ulf Landmesser
Low high-density lipoprotein (HDL) cholesterol levels are associated with an increased risk of coronary artery disease and myocardial infarction. Experimental studies have identified several potential anti-atherogenic properties of HDL, including promotion of macrophage cholesterol efflux, endothelial nitric oxide stimulation, anti-inflammatory and anti-thrombotic effects. These observations have lead to the important question of whether raising of HDL can reduce cardiovacular risk. Notably, recent studies have suggested that vascular effects of HDL can be highly heterogenous and are altered in patients with coronary disease or diabetes, that has been referred to as "HDL dysfunction"...
November 2012: Current Vascular Pharmacology
Shahbudin H Rahimtoola
No abstract text is available yet for this article.
November 2012: Current Problems in Cardiology
Kavita Prasad, Martin Kaiga Reriani, Mohammad Hassan Murad, Amit Sood, Abhiram Prasad
Mind body therapies appear to reduce morbidity and mortality in patients with cardiovascular diseases, but there is limited understanding of the mechanisms that mediate this effect. Vascular endothelial dysfunction is a central feature of atherogenesis that is adversely impacted by mental stress. We conducted a systematic review and meta-analysis of the effect of mind body therapies on peripheral endothelial function in patients with and without established cardiovascular disease. The search included Medline, Cochrane Library, Scopus and Embase to identify studies up to November 2009...
January 2011: Journal of Complementary & Integrative Medicine
Peter A McCullough, Susan Steigerwalt, Kirit Tolia, Shu-Cheng Chen, Suying Li, Keith C Norris, Adam Whaley-Connell
Diabetes mellitus (DM) and hypertension (HTN) are leading joint risk factors for both cardiovascular disease (CVD) and chronic kidney disease (CKD). In the nationwide KEEP (Kidney Early Evaluation Program) an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) or a urine albumin:creatinine ratio ≥30 mg/g (3.4 mg/mmol) defines CKD. Overall in KEEP, the rates of identified CKD and self-reported CVD are 25.7% and 22.1%, respectively. The presence of CKD has been associated with younger ages of self-reported myocardial infarction and stroke...
February 2011: Current Diabetes Reports
Petar Kes, Nikolina Basić-Jukić
Renal anemia is a well-recognized complication of chronic kidney disease (CKD). The primary cause is the deficiency of erythropoietin (EPO). There is an evident association between low hemoglobin with adverse outcomes of CKD patients. Many morbidity conditions observed in CKD patients are cardiovascular complications including left ventricular hypertrophy, ischemic heart disease, chronic heart failure, generalized atherosclerosis, and stroke. It is suggested that renal anemia, chronic renal failure, and chronic heart failure all interact to cause or worsen each other (anemia-renalcardio syndrome)...
September 2009: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Guillaume Calmettes, Véronique Deschodt-Arsac, Gilles Gouspillou, Sylvain Miraux, Bernard Muller, Jean-Michel Franconi, Eric Thiaudiere, Philippe Diolez
BACKGROUND: Hypoxic states of the cardiovacular system are undoubtedly associated with the most frequent diseases of modern time. Therefore, understanding hypoxic resistance encountered after physiological adaptation such as chronic hypoxia, is crucial to better deal with hypoxic insult. In this study, we examine the role of energetic modifications induced by chronic hypoxia (CH) in the higher tolerance to oxygen deprivation. METHODOLOGY/PRINCIPAL FINDINGS: Swiss mice were exposed to a simulated altitude of 5500 m in a barochamber for 21 days...
February 18, 2010: PloS One
G Belcaro, M R Cesarone, A Ledda, U Cornelli, M Dugall, A Di Renzo, M Hosoi, S Stuard, G Vinciguerra, L Pellegrini, G Gizzi
UNLABELLED: Fingerprints (FP), characteristic of humans, are impressions due to skin marks (ridges) on fingertips. Ridges are present on fingers/hands forming curved lines of different sizes/patterns. The point where a line stops or splits is defined typica' (their number/amount constitute identification patterns). FP are permanent and unique. This study compared FP patterns with cardiovascular risk factors: 7 main types of FP were used: 1. Arch: lines form waves from one site to the other side...
October 2008: Minerva Cardioangiologica
Kerstyn C Zalesin, Barry A Franklin, Wendy M Miller, Eric D Peterson, Peter A McCullough
The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and renin-angiotensin systems...
September 2008: Endocrinology and Metabolism Clinics of North America
Mladen Carev, Nenad Karanović, Zoran Dogas
Even though the effects of surgery and anesthesia on sleep have not been completely defined yet, it is an irrefutable fact that the patients with sleep apnea could experience significant perioperative complications, in terms of common difficult airway problems, as well as prolonged emergence from anesthesia. Besides, there are strong evidences of correlation between sleep apnea and hypertension and other cardiovascular diseases. Preoperative questions about sleep, possible snoring, or excessive daytime sleepiness should become a routine part of preanesthesia evaluation, together with airway examination and thorough pulmonary and cardiovacular examination...
March 2008: Lijec̆nic̆ki Vjesnik
Joyce Newman Giger, Deborah Jones
No abstract text is available yet for this article.
July 2007: Journal of National Black Nurses' Association: JNBNA
Toshikatsu Yagihara, Junjiro Kobayashi, Hitoshi Ogino, Koji Kagisaki, Sotaro Hanai
After a new medical expense system "DPC (Diagnosis Procedure Combination)" had been introduced in 2003, the change in the medical treatment fee was evaluated according to each cardiovascular surgical field. Application of the DPC is limited to hospitalization fee in the general ward by a fixed daily amount The former payment system remains for operation, anesthesia, and some invasive examinations such as cardiac catheterization, therefore, the influence of the DPC introduction on cardiovascular surgery was minimum...
October 2005: Nihon Geka Gakkai Zasshi
J Portolés, J M López-Gómez, P Aljama
Cardiovacular disease is the main cause of morbidity and mortality in hemodialysis (HD) patients. However, there are no reliable data neither on the prevalence of cardiovacular disease nor its risk factors in Spain. The Morbidity and mortality Anemia Renal study (MAR) is a two-year multicenter, open-label, prospective cohorts study. Its main objective is to assess the general morbidity and mortality, particularly of a cardiovascular cause, and its relationship with the degree of anemia. Secondary objectives are: a/ the description of current clinical practices in anemia, dialysis, vascular access, and CV risk factor management; and b/ the description of hospitalization and mortality causes...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
A Pérez, J M Cubero, N Sucunza, E Ortega, R Arcelús, J Rodriguez-Espinosa, J Ordoñez-Llanos, F Blanco-Vaca
Subclinical hypothyroidism (SH) is a frequent condition that may be associated with increased cardiovascular risk. There is current interest in determining the effect, if any, of substitutive therapy with l-thyroxine (L-T4) on cardiovascular risk factors in SH and, particularly, on those associated with emerging cardiovacular risk, such as apolipoprotein (apo) B, lipoprotein (Lp) (a), total homocysteine (t-Hcy), and C-reactive protein (CRP). Thus, the aim of this study was to assess the impact of euthyroidism restoration on these emerging risk factors in SH...
November 2004: Metabolism: Clinical and Experimental
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