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developmental toxicity zebrafish

Jinlei Xi, Juan Liu, Shijing He, Wanyao Shen, Cizhao Wei, Ke Li, Yufeng Zhang, Jiang Yue, Zheqiong Yang
In view of the wide application of fluoroquinolones (FQs), a group of broad-spectrum synthetic antibacterial agents, and their large ingress into the environment, the toxic effects on non-target organisms caused by FQs have received great attention. In this study, we used zebrafish embryo as a model, measured the general toxic effects of norfloxacin, a commonly used FQs, and investigated the effects of norfloxacin on the neurodevelopment of zebrafish embryos. Our data showed that norfloxacin significantly inhibited the hatching rate of zebrafish embryos, and increased the mortality and malformation rate of the embryos...
February 12, 2019: Neurotoxicology
Yang Yun, Yujie Zhang, Guangke Li, Shaoyu Chen, Nan Sang
Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of anthropogenic, persistent and very toxic PAH contaminant associated with developmental toxicity. Abnormal glucose metabolism disturbs energy balances that impair the early development of vertebrates, but the mechanisms by which maternal OPAH exposure alters glucose homeostasis in offspring are not well understood. Studies have suggested that epigenetic changes, particularly in DNA methylation, provide a memory of plastic developmental responses to the environment, leading to the generation of novel offspring phenotypes...
April 10, 2019: Science of the Total Environment
Shangbo Zhou, Qiqing Chen, Carolina Di Paolo, Ying Shao, Henner Hollert, Thomas-Benjamin Seiler
Although the effects of pharmaceuticals on aquatic organisms have been widely investigated during the last decades, toxic effects, especially delayed toxicity, during the developmental stage at environmental relevant concentrations were rarely known. In this study, a sensitive assay based on behavioral alterations was used for studying the delayed toxicity during the developmental stage on zebrafish embryos. Eight pharmaceuticals that were frequently detected with concentrations ranging from ng/l to μg/l were screened for this study...
January 24, 2019: Science of the Total Environment
Meng Jin, Xiuna Ji, Baoyue Zhang, Wenlong Sheng, Rongchun Wang, Kechun Liu
Pollutant discharges to the aquatic environment often contain multiple environmental stressors, affecting aquatic organisms. To mimic the discharges from nuclear and industry facilities, the combined effects of two independent types of stressors, heavy metal Pb and repeated heat pulse were addressed in this study. We investigated the developmental toxicity of combined treatment, especially its toxic effects on zebrafish neurodevelopment. The normal embryos at 4 hpf were exposed to 0.2 mM of Pb dissolved in the bathing medium with different temperatures (30, 32, and 34 °C) and then maintained in an incubator at 28 °C...
February 5, 2019: Ecotoxicology and Environmental Safety
Zhengyi Yang, Katy L H Cole, Yongqiang Qiu, Ildikó M L Somorjai, Philip Wijesinghe, Jonathan Nylk, Sandy Cochran, Gabriel C Spalding, David A Lyons, Kishan Dholakia
Contactless sample confinement would enable a whole host of new studies in developmental biology and neuroscience, in particular, when combined with long-term, wide-field optical imaging. To achieve this goal, we demonstrate a contactless acoustic gradient force trap for sample confinement in light sheet microscopy. Our approach allows the integration of real-time environmentally controlled experiments with wide-field low photo-toxic imaging, which we demonstrate on a variety of marine animal embryos and larvae...
February 8, 2019: Nature Communications
Xue Ma, Huizhen Li, Jingjing Xiong, W Tyler Mehler, Jing You
Agricultural use of neonicotinoid insecticides is increasing worldwide, posing a risk to non-target organisms. The present study investigated developmental toxicity of a widely used neonicotinoid, acetamiprid, to zebrafish embryos. Sub-lethal (malformations, hatchability, heart rate, body length, alteration of spontaneous movement and touch responses) and lethal effects were monitored during exposure period from 6 h post fertilization (hpf) to 120 hpf. Zebrafish embryos exhibited significant mortality and teratogenic effects at acetamiprid concentration greater than 263 mg/L, with bent spine being the main malformation...
February 8, 2019: Journal of Agricultural and Food Chemistry
Le Qian, Jie Zhang, Xiangguang Chen, Suzhen Qi, Peizhuo Wu, Chen Wang, Chengju Wang
Boscalid as one of the most widely used succinate dehydrogenase inhibitor (SDHI) fungicides has been frequently detected in both freshwater and estuarine environments. Its acute toxic effects on zebrafish and freshwater algae have been reported in our previous studies. To further investigate its chronic toxic effects to aquatic organisms, adult zebrafish were exposed for 28 days to a series of environmentally relevant boscalid concentrations in this study. Growth indicators and histopathology were determined in this study...
January 18, 2019: Environmental Pollution
Chenyang Ji, Lu Yan, Yuanchen Chen, Siqing Yue, Qiaoxiang Dong, Jiangfei Chen, Meirong Zhao
Polyhalogenated carbazoles (PHCZs), which have the similar structure of dioxin, have been reported ubiquitous in the environments and drawn wide concerns. However, their potential ecological and health risks are still poorly understood. Here, wildtype zebrafish embryos were used to evaluate the environmental risks of 2,7-dibromocarbazole (2,7-DBCZ), 3,6-dibromocarbazole (3,6-DBCZ), and 3,6-dichlorocarbazole (3,6-DCCZ). 2,7-DBCZ was the most toxic compound with the 96-h LC50 value of 581.8 ± 29.3 μg·L-1 and the EC50 value of 201...
January 24, 2019: Journal of Hazardous Materials
Wataru Yoshioka, Chiharu Tohyama
Dioxins and related compounds induce morphological abnormalities in developing animals in an aryl hydrocarbon receptor (AhR)-dependent manner. Here we review the studies in which 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) is used as a prototypical compound to elucidate the pathogenesis of morphological abnormalities. TCDD-induced cleft palate in fetal mice involves a delay in palatogenesis and dissociation of fused palate shelves. TCDD-induced hydronephrosis, once considered to be caused by the anatomical obstruction of the ureter, is now separated into TCDD-induced obstructive and non-obstructive hydronephrosis, which develops during fetal and neonatal periods, respectively...
January 31, 2019: International Journal of Molecular Sciences
Pan-Pan Jia, Tai Sun, Muhammad Junaid, Li Yang, Yan-Bo Ma, Zhi-Song Cui, Da-Peng Wei, Hao-Fei Shi, De-Sheng Pei
Graphene family nanomaterials (GFNs) have attracted significant attention due to their unique characteristics and applications in the fields of biomedicine and nanotechnology. However, previous studies highlighted the in vitro and in vivo toxicity of GFNs with size and oxidation state differences are still elusive. Therefore, we prepared graphene (G) and graphene oxide (GO) of three different sizes (S-small, M-medium, and L-large), and characterized them using multiple surface-sensitive analytical techniques...
January 24, 2019: Environmental Pollution
Mariana Bernardes Franco, Thayres S Andrade, Diego Sousa-Moura, Muriel Lopes da Silva, Irvin Bryan Machado Ferraz, Níchollas Serafim Camargo, Inês Domingues, Rhaul Oliveira, Cesar Koppe Grisolia
Psychiatric pharmaceuticals are one of the most prescribed active substances globally. Bupropion (BPP) is an antidepressant that acts via inhibition of norepinephrine and dopamine reuptake. It has been found in various water matrices, and thus its effects on aquatic organisms must be studied. The present study aimed to evaluate the acute toxic effects of BPP on zebrafish (Danio rerio) early life stages. For developmental analysis, organisms were exposed for 168 h to concentrations ranging from 0 to 82000 μg/L...
January 25, 2019: Chemosphere
Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu, Donghui Wang, Yongquan Zheng
Although previous trials have indicated that thifluzamide induces developmental inhibition in zebrafish, understanding the distinct mechanism of thifluzamide in this process remains challenging. This study investigated the effect of thifluzamide on zebrafish development and the underlying related signaling pathway. Thifluzamide repressed glucagon (GC) levels but increased growth hormone (GH) levels, and changed the expression of the genes related to growth and development. Additionally, protein kinase A (PKA) and leptin levels were obviously decreased in zebrafish after exposure to thifluzamide for 28 days, but the phosphorylation of cAMP responsive element-binding protein (CREB) was increased...
January 7, 2019: Chemosphere
Xiali Zhong, Jiahuang Qiu, Jianmeng Kang, Xiumei Xing, Xiongjie Shi, Yanhong Wei
The growing production and extensive use of organophosphate flame retardants (OPFRs) have led to an increase in their environmental distribution and human exposure. Developmental toxicity is a major concern of OPFRs' adverse health effects. However, the impact of OPFRs exposure on vascular development and the toxicity pathway for developmental defects are poorly understood. In this study, we investigated the effects of exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCPP), a frequently detected OPFR, on early vascular development, and the possible role of nuclear factor erythroid 2-related factor (Nrf2)-dependent angiogenic pathway in TDCPP's vascular toxicity...
January 3, 2019: Environmental Pollution
Stefani Altenhofen, Débora Dreher Nabinger, Paula Eliete Rodrigues Bitencourt, Carla Denise Bonan
Dichlorvos (2,2-dichlorovinyl-dimethylphosphate), an organophosphorus pesticide used for indoor insect and livestock parasite control, is among the most common commercially available pesticides. However, there are significant concerns over its toxicity, especially due to its relative stability in water, soil, and air. Zebrafish, an important developmental model, has been used for studying the effects of toxic compounds. The aim of this study was to evaluate the exposure to dichlorvos at early life stages (1 h postfertilization - 7 days postfertilization) in the zebrafish and its toxicological effects during the development, through morphological (7 days postfertilization), locomotor and social behavior analysis (7, 14, 30, 70, and 120 days postfertilization)...
February 2019: Environmental Pollution
Kate M Annunziato, Carrie E Jantzen, Melissa C Gronske, Keith R Cooper
Recent studies of perfluoroalkylated substances (PFASs) have focused on the toxicity of long chain PFASs, such as PFOS or PFOA, which have been demonstrated to cause an array of developmental and behavioral effects. However, less is known about low molecular weight PFASs and alternatives. This study examined the morphometric and behavioral effects in zebrafish following developmental exposures of C6 PFASs: perfluorohexanoic acid, PFHxA, perfluorohexane sulfonate, PFHxS, and 6:2 fluorotelomer alcohol, 6:2 FTOH...
January 14, 2019: Aquatic Toxicology
Zhenyao Huang, Bo Xu, Xiaomin Huang, Yuqing Zhang, Mingming Yu, Xiumei Han, Ling Song, Yankai Xia, Zhou Zhu, Xinru Wang, Minjian Chen, Chuncheng Lu
Iron oxides nanoparticles (FeOX NPs), including α-Fe2 O3 , γ-Fe2 O3 , and Fe3 O4 , are employed in many technological applications. However, very few studies have investigated the embryonic developmental toxicity of FeOX NPs. In this study, metabolomics analysis were used to uncover the potential mechanisms of FeOX NPs developmental toxicity on embryo-larval zebrafish and mice. Our results indicated that γ-Fe2 O3 NP treatment could cause increased mortality, dropped hatching rate, etc., while α-Fe2 O3 and Fe3 O4 NPs showed no obvious effect...
January 21, 2019: Nanotoxicology
Qimeng Shi, Yuhang Zhuang, Tingting Hu, Chuncheng Lu, Xinru Wang, Hongyu Huang, Guizhen Du
Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected in aquatic ecosystems. However, the consequence of TCC exposure on embryo development is still elusive. Here, by using zebrafish embryos, we aimed to understand the developmental defects caused by TCC exposure. After exposure to 0.3, 30, and 300 μg/L TCC from 4-hour postfertilization (hpf) to 120 hpf, we observed that TCC exposure significantly increased the mortality and malformation, delayed hatching, and reduced body length...
January 18, 2019: Journal of Biochemical and Molecular Toxicology
Mengmeng Huang, Fanghuan Zhu, Jingjing Jiao, Jun Wang, Yu Zhang
Acrylamide (AA), a ubiquitous chemical that is present in surrounding environment and baked or fried carbohydrate-rich food, has recently been linked to cardiac developmental toxicity. However, the toxicological role of AA exposure in the cardiac development remains largely unknown. Here we showed the cardiotoxicity of AA and its role in cardiomyocyte interactions in zebrafish embryos during ventricular morphogenesis. Using the embryo model of transgenic zebrafish Tg(Tp1:d2GFP;myl7:mCherry), we found AA interfered the dynamics of Notch signaling in the endocardium during early cardiogenesis...
March 15, 2019: Science of the Total Environment
Ruiwen Li, Hengqi Wang, Chuang Mi, Chenglian Feng, Ling Zhang, Lihua Yang, Bingsheng Zhou
Tris (1-chloro-2-propyl) phosphate (TCIPP) and tris (2-chloroethyl)phosphate (TCEP) are two widely used chlorinated organophosphate flame retardants (ClOPFRs), and have been frequently detected in various environmental media. Concern is now growing whether TCIPP and TCEP can cause neurotoxicity since they have similar chemical structure with organophosphorus pesticide. Therefore, in this study, zebrafish embryos (2-120 h post-fertilization [hpf]) were exposed to TCIPP or TCEP (0, 100, 500 or 2500 μg/L) or a model neurotoxicant, chlorpyrifos (CPF, 100 μg/L) to investigate the adverse effects and possible mechanisms of TCIPP and TCEP on neurodevelopment...
January 3, 2019: Chemosphere
Dennis R Carty, Zachary S Miller, Cammi Thornton, Zacharias Pandelides, Marisa L Kutchma, Kristine L Willett
While Δ9 -tetrahydrocannabinol (THC) has been widely studied in the realm of developmental and reproductive toxicology, few studies have investigated potential toxicities from a second widely used cannabis constituent, cannabidiol (CBD). CBD is popularized for its therapeutic potential for reducing seizure frequencies in epilepsy. This study investigated developmental origins of health and disease (DOHaD) via multigenerational gene expression patterns, behavior phenotypes, and reproductive fitness of a subsequent F1 following an F0 developmental exposure of zebrafish (Danio rerio) to THC (0...
December 27, 2018: Toxicology and Applied Pharmacology
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