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JOURNAL ARTICLE
Masaya Iwamuro, Daisuke Ennishi, Nobuharu Fujii, Ken-Ichi Matsuoka, Takehiro Tanaka, Toshihiro Inokuchi, Sakiko Hiraoka, Motoyuki Otsuka
BACKGROUND: Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM. METHODS: This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation for hematolymphoid neoplasms (n = 13) or thalassemia (n = 1). The sex, age at diagnosis, endoscopic features, and prognosis of each patient were assessed...
April 22, 2024: BMC Gastroenterology
#2
MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
#3
JOURNAL ARTICLE
Georgia Malamut, Craig R Soderquist, Govind Bhagat, Nadine Cerf-Bensussan
Non-responsive celiac disease (NRCD) is relatively common. It is generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications of CD and disorders clinically mimicking CD, need to be excluded. Novel therapies are being evaluated to facilitate mucosal recovery, which might benefit NRCD patients. Refractory CD (RCD) is rare and is currently divided into two types. The etiology of RCD type 1 (RCDI) is unclear, a possible switch to gluten-independent autoimmunity is suspected in some patients, while RCD type II (RCDII) represents a low-grade intraepithelial lymphoma...
March 29, 2024: Gastroenterology
#4
JOURNAL ARTICLE
Suneil A Raju, Mohamed G Shiha, Hugo A Penny
PURPOSE OF REVIEW: Persistent villous atrophy is associated with morbidity in coeliac disease and most commonly due to ongoing gluten ingestion. Current methods for assessing gluten exposure and persisting villous atrophy include dietary questionnaires and repeat duodenal biopsy, which have limited accuracy or are invasive. This review discusses adjunctive and/or novel tests that could be used to overcome these challenges. RECENT FINDINGS: Small bowel capsule endoscopy is well tolerated and helps to evaluate for persisting villous atrophy and importantly, complications associated with coeliac disease...
March 14, 2024: Current Opinion in Gastroenterology
#5
JOURNAL ARTICLE
Suneil A Raju, Emily A Greenaway, Annalisa Schiepatti, Giovanni Arpa, Nicoletta Vecchione, Chao LA Jian, Charlotte Grobler, Margherita Maregatti, Olivia Green, Freya J Bowker-Howell, Mohamed G Shiha, Hugo A Penny, Simon S Cross, Carolina Ciacci, Kamran Rostami, Shokoufeh Ahmadipour, Afshin Moradi, Mohammad Rostami-Nejad, Federico Biagi, Umberto Volta, Michelangelo Fiorentino, Benjamin Lebwohl, Peter Hr Green, Suzanne Lewis, Javier Molina-Infante, Pilar Mata-Romero, Valentina Vaira, Luca Elli, Irfan Soykan, Arzu Ensari, David S Sanders
BACKGROUND: Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive coeliac serology. We present the first, multicentre, international study of patients with USCD. METHODS: Patients with USCD were identified from 10 tertiary hospitals (6 from Europe, 2 from Asia, 1 from North America and 1 from Australasia) and compared with age-matched and sex-matched patients with conventional coeliac disease...
March 18, 2024: Gut
#6
Catarina Costa, Francisca Bartilotti Matos, Diogo Carvalho Sá, João Neves Maia
Chronic diarrhea is a common disorder in tropical regions, affecting residents, visitors, and even expatriates. It may stem from a myriad of infectious, inflammatory, and even malignant causes. In patients in whom no etiology has been found, tropical sprue (TS) is an important diagnosis to consider. We report the case of a 60-year-old man originally from Guatemala, presenting with chronic diarrhea and megaloblastic anemia due to severe vitamin B12 deficiency. Biopsies of the small bowel revealed partial villous atrophy and inflammatory infiltrate with the participation of eosinophils...
February 2024: Curēus
#7
Isairis Peralta, Elizabeth Hubbard, Laurentia Nodit
Colchicine is an alkaloid drug used in multiple medical conditions. It has a narrow therapeutic index, and gastrointestinal symptoms can occur at the beginning or after long-term therapy. Unintentional toxicity is common and has a high mortality rate when missed. Histopathologic recognition is challenging, and timely identification is conducted to improve patients' outcomes. We describe the case of a 77-year-old female who presented to the emergency room for dehydration, longstanding diarrhea, and weight loss...
January 2024: Curēus
#8
JOURNAL ARTICLE
Khaled A Abdel Baseer, Abdallah E Mohammed, Aya Mohamed Abo Elwafa, Hala M Sakhr
OBJECTIVE: The simultaneous presence of celiac disease and type 1 diabetes (T1DM) is coupled with more hazards of comorbidities and complications. This current study aimed to screen for celiac disease in Egyptian children with type 1 diabetes and evaluate its impact on glycemic control. METHODS: A cross-sectional study was verified with 200 Egyptian children diagnosed with T1DM and having a diabetic duration of less than five years. Testing for anti-tissue transglutaminase IgA (tTG-IgA), anti-tissue transglutaminase IgG (tTG-IgG), anti-Endomysial IgA (EMA), and Hb A1c levels were done...
February 5, 2024: BMC Pediatrics
#9
JOURNAL ARTICLE
Laura Passerini, Giada Amodio, Virginia Bassi, Serena Vitale, Ilaria Mottola, Marina Di Stefano, Lorella Fanti, Paola Sgaramella, Chiara Ziparo, Silvia Furio, Renata Auricchio, Graziano Barera, Giovanni Di Nardo, Riccardo Troncone, Carmen Gianfrani, Silvia Gregori
Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed immune cell composition, plasma cytokines, and gliadin-specific T-cell responses in patients with positive serology and normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), and after gluten-free diet (GFD). We found: an inflammatory signature and the presence of circulating gliadin-specific IFN-γ+ T cells in CD patients regardless of mucosal damage; an increased frequency of IL-10-secreting dendritic cells (DC-10) in the gut and of circulating gliadin-specific IL-10-secreting T cells in potential-CD; IL-10 inhibition increased IFN-γ secretion by gliadin-specific intestinal T cells from acute- and potential-CD...
February 3, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#10
REVIEW
Martina Crepaldi, Michela Palo, Daria Maniero, Luisa Bertin, Edoardo Vincenzo Savarino, Robert P Anderson, Fabiana Zingone
Celiac disease (CeD) is a chronic autoimmune disorder triggered by the ingestion of gluten, affecting around 1% of the global population. It is a multifactorial disease involving both genetics and environmental factors. Nowadays, the only available treatment for CeD is a life-long gluten-free diet (GFD), which can cause a significant burden for patients, since symptoms and mucosal injury can persist despite apparent compliance with a GFD. This could also lead to psychological consequences and affect the quality of life of these patients...
December 20, 2023: Pharmaceuticals
#11
JOURNAL ARTICLE
Laura Rodríguez Martín, Luis Manuel Vaquero Ayala, Mercedes Hernando Martín, Santiago Vivas Alegre
UNLABELLED: Study background and objectives: There is great disparity in mucosal recovery among celiac patients on a gluten-free diet. We report a study to identify associated factors. METHODS: Celiac patient cases were collected that had positive celiac serology and villous atrophy at diagnosis, and had undergone a control biopsy after at least 12 months of follow-up. RESULTS: We included 70 celiac patients. They had experienced symptoms for 9...
January 11, 2024: Revista Española de Enfermedades Digestivas
#12
REVIEW
Annalisa Schiepatti, Paolo Minerba, Michele Puricelli, Stiliano Maimaris, Giovanni Arpa, Federico Biagi, David S Sanders
BACKGROUND: Although enteropathy due to angiotensin II receptor blockers (ARBs) has been known for over 10 years, clinicians' awareness of this condition is still low. AIMS: To systematically review the literature about clinical phenotypes, distribution of mucosal changes throughout the gastrointestinal tract and prognosis of enteropathy due to ARBs. METHODS: According to PRISMA guidelines, we searched PubMed and Embase for relevant articles up to November 6, 2023...
January 7, 2024: Alimentary Pharmacology & Therapeutics
#13
JOURNAL ARTICLE
Ajay K Jain, Debi Chatterji, Priyanka Bhagat, Deepika Jain, Shohini Sircar, Satish Phatak
BACKGROUND AND AIM: Celiac disease (CeD) is mainly reported from the northern and western parts of India. In central India, it is believed to be a disease of children, with limited data among adults diagnosed for the first time after the age of 18 years. Hence, we aimed to describe CeD's clinical and demographic features among adults and children/adolescents in central India. METHODS: This is a retrospective analysis of a prospectively maintained database of all patients diagnosed for CeD from 2010 to 2019...
December 2023: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
#14
JOURNAL ARTICLE
Celiac Disease in Moroccan Children: Diagnostic Characteristics and Determinants of Diagnosis Delay.
Assia Mouslih, Karima El Rhazi, Nassiba Bahra, Mounia Lakhdar Idrissi, Moustapha Hida
Advances in the field of celiac disease have led to a better understanding of the disease, but it remains underdiagnosed and poses a daily challenge to clinicians to make a timely diagnosis. This study aims to analyze and describe diagnosis characteristics, diagnosis delay, and the factors influencing this delay in Moroccan children. Our study included 324 children diagnosed during the study period from January 01, 2010, to December 30, 2019, at the Department of Pediatrics, Hassan II University Hospital in Fez, Morocco...
December 2023: Curēus
#15
EDITORIAL
Claire L Jansson-Knodell, Alberto Rubio-Tapia
No abstract text is available yet for this article.
December 19, 2023: Digestive Diseases and Sciences
#16
JOURNAL ARTICLE
Junquan Tian, Qian Jiang, Xuetai Bao, Fan Yang, Yuying Li, Haihui Sun, Kang Yao, Yulong Yin
Piglets are particularly susceptible to oxidative stress, which causes inferior growth performance and intestinal damage. Squalene (SQ), a natural bioactive substance enriched in shark liver oil, shows excellent antioxidant properties and can currently be obtained at a low cost from deodorizer distillate during the production of plant oil. This study aimed to evaluate the effects of plant-derived SQ supplementation on the growth performance of piglets and explore the beneficial roles of SQ against oxidative stress and intestinal injury in diquat-challenged piglets...
December 2023: Animal Nutrition
#17
REVIEW
M S Kapembwa, P A Batman, S C Fleming, G E Griffin
INTRODUCTION: Chronic diarrhoea and severe wasting associated with HIV infection were first described in East African patients as SD in 1985. The main histological features are flattening of the villi (villous atrophy) and crypt hyperplasia (elongated crypts), i.e. HIVE. Selective loss of mucosal CD4+Th17+ lymphocytes is the immunological hallmark of HIVE. AIMS AND METHODS: Recent studies have highlighted the role of intestinal-resident intra-epithelial gamma delta (IRIE) T lymphocytes, mostly CD8+, in regulating gut epithelial regeneration...
December 3, 2023: International Journal of Infectious Diseases: IJID
#18
REVIEW
Meng Jin, Youzhe Gong, Wenwen Liu, Xuemei Zhong
BACKGROUND: Autoimmune enteropathy (AIE) defined by intractable diarrhoea and nonceliac enteropathy with villous atrophy, is a rare digestive disease. Case reports of this disease are sporadic and the clinical characteristics of AIE is seldom discussed. PURPOSE: We evaluate the clinical, laboratory, histopathological features, response to therapy and outcome of AIE in children. METHOD: We conducted a retrospective analysis of five children with AIE in our hospital...
November 28, 2023: BMC Pediatrics
#19
JOURNAL ARTICLE
Yang Chen, Yan You, Ji Li, Aiming Yang, Weixun Zhou, Xiaoqing Li
BACKGROUND AND AIMS: Common variable immunodeficiency disorder (CVID) patients may have gastrointestinal (GI) involvement and suffer from infections, which are poorly understood. This study aimed to evaluate the clinical, endoscopic, and histopathological features of CVID patients with GI symptoms and determine their correlation with infections. METHODS: We performed a retrospective study on 21 CVID patients with GI symptoms who underwent endoscopic examination in Peking Union Medical College Hospital from 2000 to 2020...
November 28, 2023: BMC Gastroenterology
#20
JOURNAL ARTICLE
Md Alamgir Kabir, Md Golam Rabbane, Marco R Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Waterborne cadmium (Cd) accumulates in the fish intestine and causes irreversible toxicity by disrupting intestinal immunity and microbial diversity. To explore the toxicity of environmentally available high Cd concentration on intestinal immunity and microbial diversity of fish, we selected the widely used bioindicator model species, Common carp (Cyprinus carpio). Literature review and Cd pollution data supported sequential doses of 0.2, 0.4, 0.8, 1.6, 3.2, and 6.4 mg/L Cd for 30 days. Based on intestinal tissue Cd accumulation, previous studies, and environmentally available Cd data, 0...
November 20, 2023: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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