Jinyeong Lim, Hana Lee, Seonghwa Hong, Junsoo Lee, Younghwa Kim
We comparatively evaluated the antioxidant properties of key triterpenes from Centella asiatica , including asiatic acid (AA), asiaticoside, madecassic acid, and madecassoside, in several cell types, including skin fibroblasts, macrophages, hepatocytes, and endothelial cells, under conditions promoting oxidative stress. AA conferred the highest viability on Hs68 cells exposed to ultraviolet B (UVB) irradiation. Triterpene pretreatment attenuated the UVB-induced generation of reactive oxygen species (ROS) and malondialdehyde (MDA), as well as the UVB-induced depletion of glutathione (GSH) in skin fibroblasts...
April 18, 2024: Antioxidants (Basel, Switzerland)