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tace and ablation

Dong Ho Lee, Jeong Min Lee, Pyo Nyun Kim, Yun-Jin Jang, Tae Wook Kang, Hyunchul Rhim, Jung Wook Seo, Young Joon Lee
OBJECTIVES: To evaluate and compare clinical outcomes of two different radiofrequency ablation (RFA) methods for locally recurred hepatocellular carcinoma (LrHCC) after locoregional treatment. METHODS: Our institutional review board approved this study with a waiver of informed consent. A total of 313 patients previously treated with transarterial chemoembolization (TACE) (n = 167) and RFA (n = 146) with a single LrHCC ≤ 3 cm was included from five tertiary referral hospitals...
February 15, 2019: European Radiology
Peter Isfort, Philip Rauen, Hong-Sik Na, Nobutake Ito, Saskia von Stillfried, Christiane Kuhl, Philipp Bruners
OBJECTIVES: We conducted an in vivo trial on swine to compare the ablation volumes of irreversible electroporation (IRE) followed by drug-eluting beads transarterial chemoembolization (DEB-TACE) versus IRE only. MATERIALS AND METHODS: Nine swine underwent CT-guided IRE in one liver lobe and IRE immediately followed by DEB-TACE in a different liver lobe. For DEB-TACE, 100-300 µm beads (DC-Beads® ) were loaded with 50 mg doxorubicin. For IRE, the NanoKnife® was used employing two electrodes according to the vendor's protocol...
February 8, 2019: Cardiovascular and Interventional Radiology
Kohei Ishiyama, Takashi Onoe, Haruna Kubota, Masato Kojima, Naoto Hadano, Hirofumi Tazawa, Wataru Shimizu, Takahisa Suzuki, Takeshi Sudo, Yosuke Shimizu, Takao Hinoi, Kazuya Kuraoka, Hirotaka Kouno, Hiroshi Kohno, Hirotaka Tashiro
We encountered a case of hepatic portal lymph node metastasis after repeated treatment for hepatocellular carcinoma (HCC)recurrence. A 73-year-old male patient underwent partial gastrectomy following rupture of a gastrointestinal stromal tumor 8 years ago. A 70mm tumor was simultaneously revealed in the posterior segment of the liver, and imatinib treatment was initiated based on the diagnosis of a metastatic liver tumor. Due to the absence of an increasing tendency in the tumor, extended posterior segmentectomy was performed, and the pathological diagnosis was moderately differentiated HCC...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Daisuke Takiuchi, Osakuni Morimoto, Daiki Hokkoku, Ryohei Wada, Ryo Ikeshima, Koji Munakata, Noriko Wada, Yusuke Akamaru, Hirofumi Ota, Kunitaka Shibata, Hirotsugu Ohashi
A 69-year-old man was found to have a hepatocellular carcinoma of 2.3 cm in diameter, with extrahepatic growth in liver S4 during follow-up for chronic hepatitis C and liver cirrhosis. We performed a laparoscopic partial liver resection, but the tumor capsule was injured by the retractor used to keep the working space at the bleeding site. The pathological diagnosis was moderately differentiated hepatocellular carcinoma(pT2N0M0, pStage Ⅱ). 7 months after the surgery, intrahepatic reoccurrence appeared. Thus, transcatheter arterial chemoembolization(TACE)and radiofrequency ablation were performed...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Lihui Huang, Kun Zhou, Jun Zhang, Yuhong Ma, Wei Yang, Lifeng Ran, Chengbing Jin, Dobromir Dimitrov Dimitrov, Hui Zhu
OBJECTIVE: To compare efficacy and safety of microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization (TACE) in combination with high-intensity focused ultrasound (HIFU) for treatment of patients with hepatocellular carcinoma (HCC). METHODS: According to our inclusion criteria, we retrospectively reviewed 52 patients with HCCs, and divided them into SonoVue group and TACE group. Tumors were examined by enhanced magnetic resonance imaging...
January 22, 2019: International Journal of Hyperthermia
Ashraf O Abdelaziz, Hanan Abdelhalim, Aisha M Elsharkawy, Hend I Shousha, Ahmed H Abdelmaksoud, Zeinab A Soliman, Mohamed I Seif, Dina B Sayed, Mohamed H Farouk, Tamer M Elbaz, Mohamed M Nabeel
BACKGROUND: Liver stiffness increases after the development of hepatocellular carcinoma (HCC). Transient elastography for liver stiffness measurement (LSM) using fibroscan is a simple noninvasive method of proven efficacy. This study aims to assess the changes in LSM following HCC treatment. PATIENTS AND METHODS: This study included 150 patients with hepatitis C virus related HCC attending the multidisciplinary HCC clinic, Kasr Al-Ainy Hospital between March 2014 and October 2015 who underwent either transarterial chemoembolization (TACE) or microwave ablation (MWA)...
January 11, 2019: European Journal of Gastroenterology & Hepatology
Thomas Couri, Anjana Pillai
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and its incidence continues to rise. While cirrhosis underlies most cases of HCC, many molecular pathways are implicated in HCC carcinogenesis, including the TERT promoter mutation, Wnt/β-catenin, P53, Akt/mTOR, vascular endothelial growth factor receptor (VEGFR), and endothelial growth factor receptor (EGFR)/RAS/MAPK pathways. While the most widely used staging and treatment algorithm for HCC-the Barcelona Clinic Liver Cancer (BCLC) system-does not recommend systemic molecular therapy for early HCC, a variety of treatment options are available depending upon the stage of HCC at diagnosis...
January 1, 2019: Hepatology International
S J Fang, R J Gao, L Y Zheng, Z W Zhao, X X Fan, J J Song, D K Zhang, F Z Wu, J S Ji
Objective: To analyze the clinical efficacy and safety of (125)I radioactive seed implantation in the treatment of sub-capsular hepatocellular carcinoma (sub-HCC) with sequential radiofrequency ablation and transcatheter arterial chemoembolization (TACE). Methods: The clinical data of 76 cases with advanced HCC with sub-capsular nodules including 68 males and 8 females, with an average age of (58±9) years, ranging from 33 to 78 years, enrolled in Lishui Central Hospital from January 2010 to December 2016 were collected...
December 18, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kei Endo, Hidekatsu Kuroda, Takayoshi Oikawa, Yohei Okada, Yudai Fujiwara, Tamami Abe, Hiroki Sato, Kei Sawara, Yasuhiro Takikawa
OBJECTIVES: Transcatheter arterial chemoembolization (TACE) is the standard therapy for patients with intermediate-stage hepatocellular carcinoma (HCC). This study aimed to determine whether combination therapy with radiofrequency ablation (RFA) and TACE was superior to TACE monotherapy for intermediate-stage HCC and identify cases in which this technique was the most effective. MATERIALS AND METHODS: We selected patients with intermediate HCC who met the following eligibility criteria: (1) ≥ 20 years of age, (2) receiving initial therapy, (3) ≤7 tumors, and (4) maximum tumor diameter <5 cm...
December 21, 2018: Scandinavian Journal of Gastroenterology
Timothy A Lin, Jessica S Lin, Timothy Wagner, Ngoc Pham
Stereotactic body radiation therapy (SBRT) is a form of radiation therapy that has been used in the treatment of primary hepatocellular carcinoma (HCC) over the past decade. To evaluate the clinical efficacy of SBRT in primary HCC, a literature search was conducted to identify original research articles published from January 2000 through January 2018 in PubMed on SBRT in HCC. All relevant studies published from 2004 to 2018 were included. Prospective studies demonstrated 2-year local control (LC) rates ranging from 64-95% and overall survival (OS) rates ranging from 34% (2-year) to 65% (3-year)...
October 2018: Journal of Gastrointestinal Oncology
Jasone Larrea Oleaga, Mikel Prieto Calvo, Mikel Gastaca Mateo
Transcatheter arterial chemoembolization TACE is an effective treatment for stage BCLC-B hepatocellular carcinoma (1). The development of skin lesions in the supraumbilical region is an unusual complication following this procedure. We report the case of an 80-year-old male with alcoholic liver cirrhosis, portal hypertension PHT (Child-Pugh A) and multifocal hepatocellular carcinoma. The patient had already undergone four radiofrequency ablations, one alcoholization procedure and four TACEs via femoral access...
November 19, 2018: Revista Española de Enfermedades Digestivas
Z-J Zheng, J Fu, F Zhi, W-J Liu, Y-J Guo, D-D Zhu, J-G Mo
OBJECTIVE: To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma. PATIENTS AND METHODS: 62 patients with primary hepatocellular carcinoma admitted in our hospital from June 2015 to June 2016 were enrolled in this study and divided into observation group (n = 31) and control group (n = 31) according to the random number table...
October 2018: European Review for Medical and Pharmacological Sciences
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE. Methods: This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC ≤ 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated...
October 26, 2018: Korean Journal of Internal Medicine
Lindsay A Sobotka, Alice Hinton, Lanla F Conteh
BACKGROUND AND AIMS: Geographic differences have existed in the management of hepatocellular carcinoma (HCC), and efforts to reduce regional disparities have been initiated. The aim of this study is to use the Nationwide Inpatient Sample (NIS) to determine if regional disparities in the treatment of HCC continue to exist. METHOD: A retrospective database analysis using the Nationwide Inpatient Sample was performed that included patients with a primary diagnosis of HCC...
October 21, 2018: Journal of Gastroenterology and Hepatology
Guo Tian, Shigui Yang, Jinqiu Yuan, Diane Threapleton, Qiyu Zhao, Fen Chen, Hongcui Cao, Tian'an Jiang, Lanjuan Li
OBJECTIVE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. We conducted network meta-regression within a Bayesian framework to compare and rank different treatment strategies for HCC through direct and indirect evidence from international studies. METHODS AND ANALYSES: We pooled the OR for 1-year, 3-year and 5-year overall survival, based on lesions of size ˂ 3 cm, 3-5 cm and ≤5 cm, using five therapeutic options including resection (RES), radiofrequency ablation (RFA), microwave ablation (MWA), transcatheter arterial chemoembolisation (TACE) plus RFA (TR) and percutaneous ethanol injection (PEI)...
October 18, 2018: BMJ Open
Yizhou Jiang, Shaoyi Zhou, Gang Shen, Hua Jiang, Jing Zhang
The present study is to evaluate the feasibility and efficacy of microwave ablation (MWA) combined with transcatheter arterial chemoembolization (TACE) in the treatment for unresectable hepatoblastoma in infants and children. A total of 17 patients with PRETEXT stage III and IV hepatoblastoma that was unresectable by conventional resection were included in the present study. The patients were treated with TACE, MWA, and chemotherapy. All cases were diagnosed by computed tomography (CT) and liver tumor biopsy before TACE procedure...
October 2018: Medicine (Baltimore)
N Wei, B Zhang, Y Wang, X H He, L C Xu, G D Li, Y H Wang, G Z Wang, H Z Huang, W T Li
PURPOSE: To evaluate and compare the efficiency and safety of raltitrexed- or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM). METHODS: We conducted a retrospective analysis of 81 patients with unresectable CRCLM who failed systemic chemotherapy and were treated with TACE in our department from Oct 2014 to Oct 2017. Of these, 61 patients received TACE using raltitrexed, oxaliplatin, and pirarubicin (raltitrexed group), and 20 received TACE using FUDR, oxaliplatin, and pirarubicin (FUDR group)...
October 10, 2018: Clinical & Translational Oncology
Caecilia H C Sukowati, Riccardo Patti, Devis Pascut, Rusdina B Ladju, Paola Tarchi, Nunzia Zanotta, Manola Comar, Claudio Tiribelli, Lory S Crocè
Introduction: Chronic inflammatory response is one of major contributors in the development of hepatocellular carcinoma (HCC). Inflammatory molecules, such as cytokines and growth factors in the circulation, can be useful in the diagnosis and prognosis of the patients. The stem cell growth factor beta (SCGF β ), a newly found protein, is a secreted sulfated glycoprotein and it functions as a growth factor for primitive hematopoietic progenitor cells. The level of SCGF β had been reported to be elevated in several cancer types...
2018: BioMed Research International
Yang Wang, Liang Ma, Zhuhui Yuan, Jiasheng Zheng, Wei Li
[This corrects the article DOI: 10.1371/journal.pone.0201525.].
2018: PloS One
Razvan Cerban, Carmen Ester, Speranta Iacob, Liliana Paslaru, Radu Dumitru, Mugur Grasu, Georgiana Constantin, Irinel Popescu, Liliana Gheorghe
Introduction: The aim of the study is to evaluate the role of alpha-fetoprotein (AFP) and des-y-carboxy prothrombin (DCP) in the assessment of treatment response at one month in patients with hepatocellular carcinoma (HCC) treated with trans-arterial chemoembolization (TACE). Methods: From March 2016 to April 2017 a number of 59 patients diagnosed with HCC were prospectively enrolled. A TACE procedure as initial treatment modality was performed in 41 patients. AFP and DCP serum levels were measured and clinical features were determined for all the patients that were included...
July 2018: Chirurgia
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