Xiao Wang, Huiye Zhang, Nan Zhang, Shan Zhang, Yanrong Shuai, Xiaojuan Miao, Yilan Liu, Ling Qiu, Shihui Ren, Sihan Lai, Ying Han, Hao Yao, Xupai Zhang, Fangyi Fan, Haoping Sun, Hai Yi
BACKGROUND: Metagenomic next-generation sequencing (mNGS) is a novel non-invasive and comprehensive technique for etiological diagnosis of infectious diseases. However, its practical significance has been seldom reported in the context of hematological patients with high-risk febrile neutropenia, a unique patient group characterized by neutropenia and compromised immune responses. METHODS: This retrospective study evaluated the results of plasma cfDNA sequencing in 164 hematological patients with high-risk febrile neutropenia...
2024: Frontiers in Cellular and Infection Microbiology