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Melanoma clinical pathological correlation

J E Stein, A Soni, L Danilova, T R Cottrell, T F Gajewski, F S Hodi, S Bhatia, W J Urba, W H Sharfman, M Wind-Rotolo, R Edwards, E J Lipson, J M Taube
Background: With increasing anti-PD-1 therapy use in patients with melanoma and other tumor types, there is interest in developing early on-treatment biomarkers that correlate with long-term patient outcome. An understanding of the pathologic features of immune-mediated tumor regression is key in this endeavor. Materials and Methods: Histologic features of immune-related pathologic response (irPR) following anti-PD-1 therapy were identified on hematoxylin and eosin (H&E)-stained slides in a discovery cohort of pre- and on-treatment specimens from n = 16 patients with advanced melanoma...
January 23, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Vikas Shrivastava, Phillip Bailin, Jennifer Elliott, Elizabeth Bacnik, Brian Gastman, Wilma Bergfeld, Steven D Billings, Melissa Piliang, Anthony Fernandez, Ivanka Kovalyshyn, Jennifer S Ko
BACKGROUND: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFindTM is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma. METHODS: A total of 140 high-risk patients were followed by one expert dermatologist. Biopsies were blindly and independently evaluated by two dermatopathologists and given histologic severity scores (HSS, 0-12) based on the histologic features of melanoma/dysplastic nevi and compared to pathologic diagnoses and MelaFindTM scores...
December 13, 2018: International Journal of Dermatology
Giovanni Bagnoni, Cristian Fidanzi, Angelo Massimiliano D'Erme, Paolo Viacava, Matteo Leoni, Silvia Strambi, Chiara Calani, Alessia Bertocchini, Riccardo Morganti, Claudio Spinelli
PURPOSE: This study was conducted to determine the difference in anatomo-pathological and prognostic features of cutaneous melanoma in children, adolescents and young adults. METHODS: This is a retrospective review on 383 young patients ≤ 39 years of age with cutaneous melanoma, in a period from 2006 to 2016 in Area Vasta Nord Ovest, Tuscany, Italy. We subdivided patients in three groups (children ≤ 14 years, adolescents 15-21 years, young adults 22-39 years)...
January 2019: Pediatric Surgery International
Jean-Marie Tan, Lisa N Tom, H Peter Soyer, Mitchell S Stark
Melanocytic naevi are common melanocytic proliferations that may simulate the appearance of cutaneous melanoma. Naevi commonly harbour somatic mutations implicated in melanomagenesis but in most cases lack the necessary genomic alterations required for melanoma development. While the mitogen-activated protein kinase pathway and ultraviolet radiation strongly contribute to naevogenesis, the somatic mutational landscape of dermoscopic naevus subsets distinguishes some of the molecular hallmarks of naevi in relation to melanoma...
October 17, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Swathi Kaliki, Sai Divya Jajapuram, Kavya Madhuri Bejjanki, George Ramappa, Ashik Mohamed, Dilip K Mishra
OBJECTIVE: To review the indications of enucleation in Asian Indian patients and study the trend over the 22-year period. METHODS: Retrospective study of 2009 patients who underwent enucleation. RESULTS: The mean age at presentation of patients who underwent enucleation was 155 months The histopathology diagnosis included a benign tumor (n = 22, 1%), malignant tumor (n = 1472, 73%), acute trauma (n = 93, 5%), retinal vascular disease (n = 50, 3%), inflammatory/infective pathology (n = 33, 2%), or other miscellaneous/non-specific diagnosis (n = 460, 23%)...
October 12, 2018: Eye
Elisa Moliterni, Giovanni Paolino, Nicola Veronese, Ugo Bottoni, Paola Corsetti, Michele Cardone, Dario Didona, Teresa Lopez, Stefano Calvieri
No abstract text is available yet for this article.
October 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Erika Ruiz-Garcia, Juan A Matus-Santos, Jorge Alberto Guadarrama-Orozco, Miguel Angel Alvarez-Avitia, Jose Luis Aguilar-Ponce, Edith Fernandez-Figueroa, Jessica Maldonado-Mendoza, Cesar Lopez-Camarillo, Laurence A Marchat, Saul Lino-Silva, Mario Cuellar-Hubbe, Jamie de la Garza-Salazar, Abelardo Meneses-García, Horacio Astudillo-de la Vega, Hector Martinez-Said
PURPOSE: The BRAF V600E mutation has been described in melanomas occurring in the Caucasian, European, and Asian populations. However, in the Mexican population, the status and clinical significance of BRAF mutation has not been researched on a large scale. METHODS: Consecutive BRAF-tested Mexican patients with metastatic melanoma (n = 127) were analyzed for mutations in exon 15 of the BRAF gene in genomic DNA by real-time polymerase chain reaction technology for amplification and detection...
September 2018: Journal of Global Oncology
Xiong Tingfeng, Pan Fuqiang, Li Dong
Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the Gene Expression Omnibus database to analyze how expression of these genes correlates with clinical pathology. Compared with normal skin, S100A1, S100A13, and S100B were expressed at significantly higher levels in melanoma samples...
September 13, 2018: Melanoma Research
Maja Ebert Moltara, Srdjan Novakovic, Marko Boc, Marina Bucic, Martina Rebersek, Vesna Zadnik, Janja Ocvirk
Background BRAF, NRAS and c-KIT mutations are characteristics of tumour tissues that influence on treatment decisions in metastatic melanoma patients. Mutation frequency and their correlation with histological characteristics in Slovenian population have not been investigated yet. Patients and methods In our retrospective analysis we analysed mutational status of BRAF, NRAS and c-KIT in 230 pathological samples of patients who were intended to be treated with systemic therapy due to metastatic disease at the Institute of Oncology Ljubljana between 2013 and 2016...
April 26, 2018: Radiology and Oncology
Timothy P Hanna, Carl Chauvin, Qun Miao, Michel Rizkalla, Ken Reid, Yingwei Peng, Paul Nguyen, Diederick Jalink, Sulaiman Nanji
BACKGROUND: Resection of pulmonary metastases is an important treatment option for patients with oligometastatic melanoma. There are currently no published data available on population-level outcomes. Here, we report outcomes of a registry-based study of patients who underwent lung resection for cutaneous melanoma metastases. METHODS: The study population was all cases of cutaneous melanoma in Ontario, Canada, with resection of pulmonary metastases from 2004 to 2012...
December 2018: Annals of Thoracic Surgery
Sally Y Tan, Julie Najita, Xiaoxue Li, Lauren C Strazzulla, Haili Dunbar, Mee-Young Lee, Virginia J Seery, Elizabeth I Buchbinder, Nicholas E Tawa, David F McDermott, Sandra J Lee, Michael B Atkins, Caroline C Kim
Under current AJCC staging criteria, stage IIC patients paradoxically have worse outcomes than IIIA patients despite the lack of nodal metastatic disease. This study sought to identify additional clinicopathologic characteristics correlated with worse patient outcomes. Retrospective chart review of stage IIC and IIIA melanoma patients were evaluated between 1995 and 2011 with clinical follow-up through 2015. Records were reviewed for demographics, clinical characteristics, and tumor pathology. Fisher's exact test and Wilcoxon's rank-sum test were used to assess group differences...
February 2019: Melanoma Research
Xueling Ge, Xiaohui Sui, Xiaosheng Fang, Yujie Jiang, Mei Ding, Xin Liu, Xin Wang
AIMS: To determine if Metadherin (MTDH) expression levels are positively correlated with the clinical stage of diffuse large B-cell lymphoma (DLBCL) based on MTDH being highly expressed in other type of tumors including melanoma, malignant glioma, breast cancer, and hepatocellular carcinoma. In this study, we investigated the pathologic significance of MTDH and its potential in predicting DLBCL outcomes. MATERIALS AND METHODS: Tissue samples from 50 patients with DLBCL and 22 patients with lymph node reactive hyperplasia were collected and evaluated using immunohistochemical staining, microscopy, and western blotting...
August 2018: Genetic Testing and Molecular Biomarkers
Ali C Ravanpay, Ariana Barkley, Gabrielle A White-Dzuro, Patrick J Cimino, Luis F Gonzalez-Cuyar, Christina Lockwood, Lia M Halasz, Fuki M Hisama, Manuel Ferreira
BACKGROUND: Rhabdoid meningiomas are rare World Health Organization grade 3 tumors that tend to follow an aggressive course, with an increased likelihood for local recurrence, remote metastasis, and cerebrospinal fluid dissemination. Genetic testing has found certain genes associated with reduced time to tumor recurrence. BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene that is associated with multiple tumors, including rhabdoid meningiomas. CASE DESCRIPTION: We present a case of a pediatric patient who presented with a rhabdoid meningioma occurring in the right tentorium and invading multiple venous structures, including the right jugular vein...
November 2018: World Neurosurgery
M T Tetzlaff, J L Messina, J E Stein, X Xu, R N Amaria, C U Blank, B A van de Wiel, P M Ferguson, R V Rawson, M I Ross, A J Spillane, J E Gershenwald, R P M Saw, A C J van Akkooi, W J van Houdt, T C Mitchell, A M Menzies, G V Long, J A Wargo, M A Davies, V G Prieto, J M Taube, R A Scolyer
Background: Clinical trials have recently evaluated safety and efficacy of neoadjuvant therapy among patients with surgically resectable regional melanoma metastases. To capture informative prognostic data connected to pathological response in such trials, it is critical to standardize pathologic assessment and reporting of tumor response after this treatment. Methods: The International Neoadjuvant Melanoma Consortium meetings in 2016 and 2017 assembled pathologists from academic centers to develop consensus guidelines for pathologic examination and reporting of surgical specimens from AJCC (8th edition) stage IIIB/C/D or oligometastatic stage IV melanoma patients treated with neoadjuvant-targeted or immune therapy...
August 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Camelia Tamaş, Cătălina Teodora Pintilie, Ionuţ Vivi Atănăsoae, Andreea Mioara Corduneanu, Iulia Dabija, Florin Ştefan Olaru, Irina Mihaela Hreniuc, Angela Tecuceanu, Ioana Munteanu, Costel Dobre, Dan Cristian Moraru, Victor Ianole, Ioana Tamaş, Victor Vlad Costan
PURPOSE: The face is an unfortunate location for any type of tumor - malignant or not - with significant esthetic and functional outcomes. To reconstruct a facial defect may seem simple, but can be rather complicated. The aim of this study is to analyze and discuss our results in order to conclude with specific surgical strategies correlated with the morphopathological results. The most important objective for us is to offer the highest level of expertise to our patients and to prove that the symbiosis between the surgical treatment and the work of the Department of Morphopathology is essential in order to maximize the quality of medical care provided for our patients...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Hyo Jung Park, Hyun Jin Kim, Seong Ho Park, Jong Seok Lee, Ah Young Kim, So-Woon Kim, Seung-Mo Hong
OBJECTIVE: The purpose of this study is to evaluate the MRI features of primary anorectal malignant melanoma and to correlate these features with its clinical and pathologic characteristics. MATERIALS AND METHODS: The medical records of 12 patients (five men and seven women; mean age [± SD], 60.8 ± 10.0 years) with pathologically proven primary anorectal melanoma were retrospectively reviewed. MRI findings were analyzed to determine the shape, size, distance from the anal verge, presence of perirectal or anal infiltration, signal intensity on T1- and T2-weighted images, presence of diffusion restriction, contrast enhancement pattern of the lesion, presence of lymphadenopathy, and occurrence of bowel obstruction...
August 2018: AJR. American Journal of Roentgenology
G Brancaccio, B Brunetti, E Fulgione, E Moscarella, R Alfano, G Argenziano
No abstract text is available yet for this article.
June 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Aparna Harbhajanka, Satyapal Chahar, Kristy Miskimen, Paula Silverman, Lyndsay Harris, Nicole Williams, Vinay Varadan, Hannah Gilmore
The transcription factor SOX10 mediates the differentiation of neural crest-derived cells, and SOX10 by immunohistochemistry(IHC) is used primarily for the diagnosis of melanoma. SOX10 expression has been previously documented in benign breast myoepithelial cells. However there is limited literature on its expression in triple negative breast carcinoma(TNBC). The aim was to study the clinical, pathologic and molecular profiles of SOX10+ tumors in TNBC. Tissue microarrays of TNBC were evaluated for SOX10 expression in 48cases...
June 9, 2018: Human Pathology
X X Zhang, Y Fang, L B Xu, S F Xu, Z G Zhao, C Sun, P Q Ma, T Liu, S J Yu, W J Zhang
Objective: To evaluate the clinical value of preoperative (18)F-Fludeoxyglucose ((18)F-FDG PET-CT) in lymphatic metastasis diagnosis of cutaneous melanoma on extremities and trunk. Methods: 112 patients with cutaneous melanoma pathologically of extremities and trunk from January 2006 to December 2016, who received (18)F-FDG PET-CT examination preoperatively, were retrospectively reviewed. The correlations between the maximal diameters of lymph nodes, the maximal standard uptake value (SUV) and the diagnostic impression grades of PET-CT examination, and the final pathological diagnosis were analyzed...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Andrea Kozárová, Marek Kozár, Ingrid Tonhajzerová, Táňa Pappová, Eva Minariková
High-frequency ultrasonography has become an important diagnostic tool in dermatovenerology. It is used for assessment of the cutaneous layers in diverse benign and malignant skin lesions and diseases. Herein we present the practical value of preoperative measurement of cutaneous melanoma thickness, the explanation of the possible reasons for different sonographic and histologic Breslow thickness, and the practical importance of high-frequency 20 MHz ultrasonography in preoperative measurements of cutaneous melanoma thickness...
April 2018: Acta Dermatovenerologica Croatica: ADC
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