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https://read.qxmd.com/read/30781634/mortality-risk-and-risk-factors-in-patients-with-posttraumatic-epilepsy-a-population-based-cohort-study
#1
Wei-Jun Lin, Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
Aim: Use the National Health Insurance Research Database of Taiwan to determine whether patients with posttraumatic epilepsy (PTE) have an increased risk of mortality. Methods: Patients ≥20 years old ever admitted because of head injury (per International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 850⁻854 and 959.01) during 2000⁻2012 were enrolled into a traumatic brain injury (TBI) cohort. The TBI cohort was divided into with PTE (ICD-9-CM code 345) and posttraumatic nonepilepsy (PTN) cohorts...
February 18, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30781588/long-non-coding-rnas-in-the-regulation-of-gene-expression-physiology-and-disease
#2
REVIEW
Juliane C R Fernandes, Stephanie M Acuña, Juliana I Aoki, Lucile M Floeter-Winter, Sandra M Muxel
The identification of RNAs that are not translated into proteins was an important breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene expression. These non-coding RNAs can be divided into two main classes according to their length: short non-coding RNAs, such as microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). The lncRNAs in association with other molecules can coordinate several physiological processes and their dysfunction may impact in several pathologies, including cancer and infectious diseases...
February 17, 2019: Non-Coding RNA
https://read.qxmd.com/read/30779945/pgpbs-a-mitogen-activated-protein-kinase-kinase-is-required-for-vegetative-differentiation-cell-wall-integrity-and-pathogenicity-of-the-barley-leaf-stripe-fungus-pyrenophora-graminea
#3
Qianqian Liang, Baochun Li, Junchen Wang, Panrong Ren, Lirong Yao, Yaxiong Meng, Erjing Si, Xunwu Shang, Huajun Wang
The high-osmolarity glycerol (HOG) signaling pathway regulates the adaptation of fungi to environmental stressors. The mitogen-activated protein kinase kinase (MAPKK) PBS2 of Saccharomyces cerevisiae serves as a scaffold protein in the HOG pathway. We characterized the pgpbs gene of Pyrenophora graminea, which encodes a MAPKK that is 56% orthologous to PBS2 of S. cerevisiae. A cloning technique based on homology was applied to amplify the pgpbs gene. Specific silent mutations then were generated in pgpbs. We evaluated the potential roles of PGPBS in the osmotic response, vegetative differentiation, cell wall integrity, drug resistance, and pathogenicity...
February 16, 2019: Gene
https://read.qxmd.com/read/30779777/the-impact-of-dementia-on-hospital-outcomes-for-elderly-patients-with-sepsis-a-population-based-study
#4
Carmen Bouza, Gonzalo Martínez-Alés, Teresa López-Cuadrado
BACKGROUND: Prior studies have suggested that dementia adversely influences clinical outcomes and increases resource utilization in patients hospitalized for acute diseases. However, there is limited population-data information on the impact of dementia among elderly hospitalized patients with sepsis. METHODS: From the 2009-2011 National Hospital Discharge Database we identified hospitalizations in adults aged ≥65 years. Using ICD9-CM codes, we selected sepsis cases, divided them into two cohorts (with and without dementia) and compared both groups with respect to organ dysfunction, in-hospital mortality and the use of hospital resources...
2019: PloS One
https://read.qxmd.com/read/30779758/parasite-specific-7sl-derived-small-rna-is-an-effective-target-for-diagnosis-of-active-trypanosomiasis-infection
#5
Stephen M Chiweshe, Pieter C Steketee, Siddharth Jayaraman, Edith Paxton, Kyriaki Neophytou, Heidi Erasmus, Michel Labuschagne, Anneli Cooper, Annette MacLeod, Finn E Grey, Liam J Morrison
Human and animal African trypanosomiasis (HAT & AAT, respectively) remain a significant health and economic issue across much of sub-Saharan Africa. Effective control of AAT and potential eradication of HAT requires affordable, sensitive and specific diagnostic tests that can be used in the field. Small RNAs in the blood or serum are attractive disease biomarkers due to their stability, accessibility and available technologies for detection. Using RNAseq, we have identified a trypanosome specific small RNA to be present at high levels in the serum of infected cattle...
February 19, 2019: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/30779705/age-and-poverty-status-alter-the-coding-and-noncoding-transcriptome
#6
Nicole Noren Hooten, Michele K Evans
Emerging evidence indicates that noncoding RNAs play regulatory roles in aging and disease. The functional roles of long noncoding RNAs (lncRNAs) in physiology and disease are not completely understood. Little is known about lncRNAs in the context of human aging and socio-environmental conditions. Microarray profiling of lncRNAs and mRNAs from peripheral blood mononuclear cells from young and old white (n=16) and African American (AA) males (n=16) living above or below poverty from the Healthy Aging in Neighborhoods of Diversity across the Life Span study revealed changes in both lncRNAs and mRNAs with age and poverty status in white males, but not in AA males...
February 17, 2019: Aging
https://read.qxmd.com/read/30779194/proton-pump-inhibitors-and-risk-of-acute-and-chronic-kidney-disease-a-retrospective-cohort-study
#7
Emily Hart, Terry E Dunn, Steven Feuerstein, David M Jacobs
BACKGROUND: Proton pump inhibitors (PPIs) have been linked to acute kidney injury (AKI) and chronic kidney disease (CKD); however, current evidence has only been evaluated in a small number of studies with short follow-up periods. This study examined the association between PPI use and risk of incident AKI and CKD in a large, population-based health-maintenance organization (HMO) cohort. METHODS: Patients aged 18 years or older, without evidence of pre-existing renal disease, started on PPI therapy, and continuously enrolled for at least 12 months between July 1993 and September 2008 were identified in an HMO database...
February 18, 2019: Pharmacotherapy
https://read.qxmd.com/read/30779067/lncrna-rmrp-promotes-proliferation-migration-and-invasion-of-bladder-cancer-via-mir-206
#8
H-L Cao, Z-J Liu, P-L Huang, Y-L Yue, J-N Xi
OBJECTIVE: The incidence of bladder cancer (BC) is common in the world, but its detail mechanisms for occurrence and development remain unclear. Recently, long non-coding RNAs (lncRNAs) have been observed to play an important role in many different diseases. In this research, we mainly explored the role of the RNA component of mitochondrial RNA processing endoribonuclease (lncRNA-RMRP) in bladder cancer. MATERIALS AND METHODS: We used qRT-PCR to detect the expression of lncRNA-RMRP in bladder cancer patients and tumor cells, and the clinical significance was also analyzed...
February 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/30779033/studying-the-replication-history-of-human-b-lymphocytes-by-real-time-quantitative-rq-pcr
#9
Menno C van Zelm
The cells of the adaptive immune system, B and T lymphocytes, each generate a unique antigen receptor through V(D)J recombination of their immunoglobulin (Ig) and T-cell receptor (TCR) loci, respectively. Such rearrangements join coding elements to form a coding joint and delete the intervening DNA as circular excision products containing the signal joint. These excision circles are stable structures that cannot replicate and have no function in the cell. Since the coding joint in the genome is replicated with each cell division, the ratio between coding joints and signal joints in a population of B cells can be used as a measure for proliferation...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30779024/sm-rcnv-a-statistical-method-to-detect-recurrent-copy-number-variations-in-sequenced-samples
#10
Yaoyao Li, Xiguo Yuan, Junying Zhang, Liying Yang, Jun Bai, Shan Jiang
BACKGROUND: Copy number variation (CNV) is an important form of genomic structural variation and is linked to dozens of human diseases. Using next-generation sequencing (NGS) data and developing computational methods to characterize such structural variants is significant for understanding the mechanisms of diseases. OBJECTIVE: The objective of this study is to develop a new statistical method of detection recurrent CNVs across multiple samples from genomic sequences...
February 18, 2019: Genes & Genomics
https://read.qxmd.com/read/30778019/clinical-classification-of-rare-cardiac-arrhythmogenic-and-conduction-disorders-and-rare-arrhythmias
#11
Piotr Podolec, Adrian Baranchuk, Josep Brugada, Piotr Kukla, Jacek Lelakowski, Grzegorz Kopeć, Paweł Rubiś, Jakub Stępniewski, Jakub Podolec, Monika Komar, Lidia Tomkiewicz-Pająk, Paweł Tomasz Matusik
INTRODUCTION Rare cardiovascular diseases and disorders (RCDD) constitute important clinical problems and their proper classification is crucial for expanding knowledge in the field of RCDD. The aim of this paper is to provide an updated classification of rare arrhythmogenic and conduction disorders, and rare arrhythmias (RACDRA). METHODS We performed a search for RACDRA using the Orphanet rare diseases inventory, which includes diseases having a prevalence of 5 per 10 000 in the general population or less...
February 19, 2019: Polish Archives of Internal Medicine
https://read.qxmd.com/read/30777619/a-hospital-wide-predictive-model-for-unplanned-readmission-using-hierarchical-icd-data
#12
M Deschepper, K Eeckloo, D Vogelaers, W Waegeman
BACKGROUND AND OBJECTIVE: Hospitals already acquire a large amount of data, mainly for administrative, billing and registration purposes. Tapping on these already available data for additional purposes, aiming at improving care, without significant incremental effort and cost. This potential of secondary patient data is explored through modeling administrative and billing data, as well as the hierarchical structure of pathology codes of the International Classification of Diseases (ICD) in the prediction of unplanned readmissions, as a clinically relevant outcome parameter that can be impacted on in a quality improvement program...
February 13, 2019: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/30777365/post-traumatic-stress-disorder-and-serum-cytokine-and-chemokine-concentrations-in-patients-with-rheumatoid-arthritis-%C3%A2
#13
P M Maloley, B R England, H Sayles, G M Thiele, K Michaud, J Sokolove, G W Cannon, A M Reimold, G S Kerr, J F Baker, L Caplan, A J Case, T R Mikuls
OBJECTIVE: Although post-traumatic stress disorder (PTSD) is identified as a risk factor in the development of rheumatoid arthritis (RA), associations of PTSD with disease progression are less clear. To explore whether PTSD might influence disease-related measures of systemic inflammation in RA, we compared serum cytokine/chemokine (cytokine) concentrations in RA patients with and without PTSD. METHODS: Participants were U.S. Veterans with RA and were categorized as having PTSD, other forms of depression/anxiety, or neither based on administrative diagnostic codes...
February 8, 2019: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/30777322/cardiovascular-outcomes-of-patients-with-pulmonary-hypertension-undergoing-noncardiac-surgery
#14
Nathaniel R Smilowitz, Andrew Armanious, Sripal Bangalore, Harish Ramakrishna, Jeffrey S Berger
Pulmonary hypertension (PH), defined by a mean pulmonary artery pressure of >25mm Hg at rest, is strongly associated with morbidity and mortality in the perioperative period. The prevalence and outcomes of PH among patients referred for major noncardiac surgery in the United States are unknown. Patients ≥18 years of age hospitalized for noncardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data from 2004 to 2014. Pulmonary hypertension was defined by International Classification of Diseases, Ninth Revision diagnosis codes...
February 8, 2019: American Journal of Cardiology
https://read.qxmd.com/read/30777110/the-cumulative-incidence-and-trends-of-rare-diseases-in-south-korea-a-nationwide-study-of-the-administrative-data-from-the-national-health-insurance-service-database-from-2011-2015
#15
Sung-Shil Lim, Wanhyung Lee, Yeong-Kwang Kim, Jihyun Kim, Jong Heon Park, Bo Ram Park, Jin-Ha Yoon
BACKGROUND: The burden of rare diseases on society and patients' families has increased in Korea. However, because of the infrequency of rare diseases, there is a lack of resources and information to address these cases and inadequate funding for the management of these patients. We investigated the average annual cumulative incidence of rare diseases and the trends in annual cumulative incidence from 2011 to 2015 in Korea by using nationwide administrative data from the Korean National Health Insurance Service (NHIS) database for patients registered with the co-payment assistance policy for rare and incurable diseases...
February 18, 2019: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/30777076/circpsmc3-suppresses-the-proliferation-and-metastasis-of-gastric-cancer-by-acting-as-a-competitive-endogenous-rna-through-sponging-mir-296-5p
#16
Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang, Hongyong Cao
BACKGROUND: Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop structure, but its functions remain largely unknown. Growing evidence has revealed that circRNAs play a striking role as functional RNAs in the progression of malignant disease. However, the precise role of circRNAs in gastric cancer (GC) remains unclear. METHODS: CircRNAs were determined by human circRNA array analysis and quantitative reverse transcription polymerase reaction. Luciferase reporter, RNA pull down, and fluorescence in situ hybridization assays were employed to test the interaction between circPSMC3 and miR-296-5p...
February 18, 2019: Molecular Cancer
https://read.qxmd.com/read/30777014/subcongenic-analysis-of-a-quantitative-trait-locus-affecting-body-weight-and-glucose-metabolism-in-zinc-transporter-7-znt7-knockout-mice
#17
L Huang, S Tepaamorndech, C P Kirschke, Y Cai, J Zhao, Xiaohan Cao, Andrew Rao
BACKGROUND: A genome-wide mapping study using male F2 zinc transporter 7-knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B6) background identified a quantitative trait locus (QTL) on chromosome 7, which had a synergistic effect on body weight gain and fat deposit with the znt7-null mutation. RESULTS: The genetic segment for body weight on mouse chromosome 7 was investigated by newly created subcongenic znt7-KO mouse strains carrying different lengths of genomic segments of chromosome 7 from the 129P1 donor strain in the B6 background...
February 18, 2019: BMC Genetics
https://read.qxmd.com/read/30776767/the-cost-of-hypoglycemia-associated-with-type-2-diabetes-mellitus-in-taiwan
#18
Alena Strizek, Chee-Jen Chang, Wesley Furnback, Bruce Wang, Jérémie Lebrec, Thomas Lew
OBJECTIVES: To quantify the incremental burden of patients with type 2 diabetes mellitus (T2DM) and a hypoglycemic event in Taiwan using the National Health Insurance Research Database. METHODS: Data from 2000 through 2013 with an index period of 2001 through 2012 from the National Health Insurance Research Database's 2-million-patient sample were used. Using a nested case-control study design, patients were indexed if they reported a diagnosis of T2DM during the index period...
February 15, 2019: Value in Health Regional Issues
https://read.qxmd.com/read/30776703/very-high-high-density-lipoprotein-cholesterol-is-associated-with-increased-all-cause-mortality-in-south-koreans
#19
In-Hwan Oh, Junho K Hur, Jae-Hong Ryoo, Ju Young Jung, Sung Keun Park, Hong Jun Yang, Joong-Myung Choi, Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh
BACKGROUND AND AIMS: Our study aimed to investigate the association between high-density lipoprotein cholesterol (HDL-C) and all-cause and cause-specific mortality in Korean adults. METHODS: A total of 365,457 participants aged ≥40 years were selected from the Korean National Health Insurance Service-National Sample Cohort from 2009 to 2015. HDL-C level was categorized into <1.0, 1.0-1.19, 1.2-1.39, 1.4-1.59, 1.6-1.79 (reference), 1.8-1.99, 2.0-2.19 and ≥ 2...
February 5, 2019: Atherosclerosis
https://read.qxmd.com/read/30776697/gene-mutational-analysis-in-a-cohort-of-chinese-children-with-unexplained-epilepsy-identification-of-a-new-kcnd3-phenotype-and-novel-genes-causing-dravet-syndrome
#20
Jiaping Wang, Yongxin Wen, Qingping Zhang, Shujie Yu, Yan Chen, Xiru Wu, YueHua Zhang, Xinhua Bao
PURPOSE: This study aimed to investigate the genetic etiology of epilepsy in a cohort of Chinese children. METHODS: Targeted next-generation sequencing (NGS) was performed for 120 patients with unexplained epilepsy, including 71 patients with early-onset epileptic encephalopathies, and 16 patients with Dravet syndrome (including three patients with a Dravet-like phenotype) but without SCN1A pathogenic variants. RESULTS: Pathogenic variants of 14 genes were discovered in 22 patients (18%)...
January 28, 2019: Seizure: the Journal of the British Epilepsy Association
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