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Estrogenic Foods

Fabio Barra, Giovanni Grandi, Matteo Tantari, Carolina Scala, Fabio Facchinetti, Simone Ferrero
Endometriosis is a chronic benign estrogen dependent disease characterized by the presence of endometriotic glands and stroma outside the uterine cavity. Although combined hormonal contraceptives and progestins, currently available first-line treatments for endometriosis, are efficacious and well tolerated for treating disease-related pain, some women experience partial or no improvement of pain or its recurrence is frequent after discontinuation of the therapies. For these reasons, new drugs are under investigation for the treatment of endometriosis...
February 14, 2019: Expert Opinion on Biological Therapy
Tang-Tian He, Tao Zhang, Shi-Bo Liu, Jing-Chun Shi, Yi-Sheng Huang, Huai-Ping Zheng, Wen-Hua Liu
Benzotriazole and its associated derivatives (BTs) are widely used as ultraviolet stabilizers and corrosion inhibitors. They have been extensively found in marine environments and are bioaccumulative through the food chain. However, the toxicities of BTs to marine organisms are seldom identified and no assessment has been conducted for filter-feeding bivalves. In this study, a marine scallop Chlamys nobilis was exposed to 0, 0.01, 0.1, and 1.0 mg/L of BT for 60 days. Effects of BT on endocrine system, cytochrome P450 activity, antioxidant activity, and neural activity of C...
February 13, 2019: Environmental Science and Pollution Research International
Mahshid Hatami, Farhad Vahid, Mohammad Esmaeil Akbari, Mahya Sadeghi, Fatemeh Ameri, Hassan Eini-Zeinab, Yasaman Jamshidi-Naeini, Sayed Hossein Davoodi
BACKGROUND: Some micronutrients like folate, vitamin B12, B6, and B2 are the source of coenzymes, which participate in one-carbon metabolism. Any disruption in this metabolism can interfere with DNA replication, repair and regulation of gene expression and ultimately promote the likelihood of carcinogenesis. This study aimed at investigating the relationship between the intakes of micronutrients involved in one-carbon metabolism with breast cancer (BrCa) and its subtype's odds. METHODS: Nutrients' intake from diet and supplements were collected through interviewing 151 cases and 154 controls by a 168-item semiquantitative food frequency questionnaire...
February 13, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Patricia De Campos, Isabela M Oliveira, Janaina Sena de Souza, Rodrigo Rodrigues Da Conceição, Gisele Giannocco, Maria I Chiamolera, Magnus R Dias-Da Silva, Marco A Romano, Renata Marino Romano
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that is widely used in the manufacturing of plastics and inner linings of food cans. Previously, it was reported that BPA disturbed the sexual dimorphic nucleus of the hypothalamus and delaying the onset of puberty attributed to an estrogenic action. In addition, BPA during the perinatal period increased LH serum concentrations in male offspring of dams at doses below the reproductive NOAEL (No Observable Adverse Effect Level) based upon World Health Organization guidelines...
February 12, 2019: Journal of Toxicology and Environmental Health. Part A
Kuei-Pin Huang, Charlotte C Ronveaux, Guillaume de Lartigue, Nori Geary, Lori Asarian, Helen E Raybould
Deletion of the leptin receptor from vagal afferent neurons (VAN) using a conditional deletion (Nav1.8/LepRfl/fl ) results in an obese phenotype with increased food intake and lack of exogenous cholecystokinin (CCK)-induced satiation in male mice. Female mice are partially protected from weight gain and increased food intake in response to ingestion of high-fat (HF) diets. However, whether lack of leptin signaling in VAN leads to an obese phenotype or disruption of hypothalamic-pituitary-gonadal axis function in female mice is unclear...
February 12, 2019: American Journal of Physiology. Endocrinology and Metabolism
Tianzhu Guan, Yonghai Sun, Yongjun Wang, Zhuolin Li, Tiezhu Li, Ligang Hou
The rapid analysis of stilbene estrogens is crucially important in the environment, food and health sectors, but quantitation of lower detection limit for stilbene estrogens persists as a severe challenge. We herein described a homologous and sensitive fluorescence polarization (FP) assay based on estrogen receptor α ligand binding domain (ER-LBD) to monitor stilbene estrogens in milk. Under optimal conditions, the half maximal inhibitory concentrations (IC50 ) of the FP assay were 9.27 nM, 12.94 nM, and 22...
February 10, 2019: International Journal of Molecular Sciences
Hee-Seok Lee, Na-Yeon Kim, YoungSun Song, Gyeong-Yong Oh, Da-Woon Jung, Da-Hyun Jeong, Hui-Seung Kang, Hyun-Sook Oh, Yooheon Park, Jeong Sup Hong, Yong Eui Koo
The presence of veterinary drug residues in foods and the environment could potentially cause adverse effects on humans and wildlife. Several veterinary drugs were reported to exhibit endocrine disrupting effects via binding affinities to sexual hormone receptors such as estrogen and androgen receptors. Therefore, we confirmed the human estrogen receptor (ER) agonistic/antagonistic effects of 135 chemicals that were used as veterinary drugs in Korea by the official Organization for Economic Cooperation and Development (OECD) in vitro ER transcriptional activation (TA) assay using the VM7Luc4E2 cell line...
February 8, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Larissa Rugila S Stopa, Camila F de Souza, Geisielle Fernandes Santos, Andressa B Martins, Renan Nascimento Ferreira, Fábio Goulart de Andrade, Cristiane Mota Leite, Dimas A M Zaia, Cassia Thaïs B V Zaia, Ernane Torres Uchoa
Glucocorticoids (GC) increase food intake and body weight in humans and rodents, and chronic stress and GC treatment-induced enhancement on plasma concentration of GC leads to obesity and metabolic changes. In response to hypercaloric treatment, males were shown to be more susceptible to obesity compared to females, demonstrating that intersexual differences may affect energy homeostasis. The objective of the current study was to evaluate the effects of prolonged (28 days) treatment with dexamethasone or corticosterone in intact rats, both male and female, on food intake, body weight gain, Lee index, weights and area of adipocytes of retroperitoneal and perigonadal+perirenal adipose tissues, glucose tolerance test (GTT) and plasma concentrations of free fatty acids, cholesterol and triglycerides...
February 6, 2019: Steroids
Ren Liu, Xiaolin Xu, Chenglin Liang, Xin Chen, Xiaowei Yu, Hongfei Zhong, Wenxiu Xu, Yu Cheng, Wei Wang, Yudong Wu, Lehan Yu, Xiaojuan Hu
As one of the typical food-derived phytoestrogens, genistein (GEN) could bind to estrogen receptor (ER) and was reported to be closely related to breast cancer. Our former research showed that GEN interfered with the anti-tumor effects of cisplatin (CIS) in breast cancer MCF-7 (ERα+/ERβ-) cells. However, it is not clear whether ER expression pattern affects GEN's modulation on CIS's activity. In the present study, breast cancer ERβ knockdown (ERβKD) MDA-MB-231 (ERα-/ERβ+) cell model was established via ERβ RNAi lentivirus infection...
February 8, 2019: Molecular and Cellular Biochemistry
Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li, Jiayuh Lin
BACKGROUND: Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. IL-11 signaling has been recently identified as a potential therapeutic target in colon cancer. Bazedoxifene, a third- generation selective estrogen modulator approved by the Food and Drug Administration (FDA), is a novel inhibitor of IL-11/GP130 signaling discovered by docking modeling. METHODS: In this study, the inhibition efficacy of bazedoxifene in colon cancer cells and its potential mechanism were investigated in vitro and in vivo by using MTT cell viability assay, BrdU cell proliferation assay, colony formation assay, wound-healing/cell migration assay, immunofluorescence, western blot assay and the mouse xenograft tumor model...
February 8, 2019: Journal of Experimental & Clinical Cancer Research: CR
Kaifeng Deng, Shanying Mo, Xuexiang Liu, Jifei Chen, Qiaoyun Zhang, Xiaoli Chen, Jianming Chen, Shengming Dai
BACKGROUND: Based on estrogen active substances, many women consume soy foods in the belief that it could prevent breast cancer (BC). Women with different molecular subtypes would be likely to have diverse reactions to soy foods, especially those with the estrogen-receptor-positive (ER+ ) subtype. The aim of the current study is to identify the differentially expressed genes (DEGs) on soy foods in premenopausal patients with Lumina A subtype of BC (LABC) after soy food treatment, and to further investigate the critical molecule change...
December 12, 2018: Clinical Breast Cancer
Danielle Naville, Guillain Gaillard, Benoit Julien, Nathalie Vega, Claudie Pinteur, Stéphanie Chanon, Hubert Vidal, Brigitte Le Magueresse-Battistoni
Excessive consumption of industrialized food and beverages is a major etiologic factor in the epidemics of obesity and associated metabolic diseases because these products are rich in fat and sugar. In addition, they contain food contact materials and environmental pollutants identified as metabolism disrupting chemicals. To evaluate the metabolic impact of these dietary threats (individually or combined), we used a male mouse model of chronic exposure to a mixture of low-dose archetypal food-contaminating chemicals that was added in standard or high-fat, high-sucrose (HFHS) diet...
April 2019: Chemosphere
Shuyue Ren, Qiaofeng Li, Ye Li, Shuang Li, Tie Han, Jiang Wang, Yuan Peng, Jialei Bai, Baoan Ning, Zhixian Gao
This study describes an upconversion fluorescent aptasensor based on black phosphorus nanohybrids and self-assembled DNA tetrahedrons dual-amplification strategy for rapid detection of the environmental estrogens bisphenol A (BPA) and 17β-estradiol (E2). Tetrahedron complementary DNAs (T-cDNAs) were self-assembled in an oriented fashion on a 2D nanohybrid composed of black phosphorus (BP) and gold to give a materials of architecture BP-Au@T-cDNAs. In parallel, core-shell upconversion nanoparticles were modified with aptamers (UCNPs@apts) and used as capture probes...
February 2, 2019: Mikrochimica Acta
Xuelian Bai, Kumud Acharya
The present endocrine disrupting chemicals (EDCs) in wastewater effluents due to incomplete removal during the treatment processes may cause potential ecological and human health risks. This study evaluated the removal and uptake of seven EDCs spiked in two types of wastewater effluent (i.e., ultrafiltration and ozonation) and effluent cultivated with the freshwater green alga Nannochloris sp. In ultrafiltration effluent cultivated with Nannochloris sp. for 7 days, the removal rate of 17β-estradiol (E2), 17α-ethinylestradiol (EE2), and salicylic acid (SAL) was 60%; but Nannochloris sp...
January 24, 2019: Environmental Pollution
Toshiyuki Yasui, Yuki Ideno, Yoko Onizuka, Junko Nakajima-Shimada, Jung-Su Lee, Hiromitsu Shinozaki, Mikiko Kishi, Reiko Suzuki, Kunihiko Hayashi
Results of studies on the associations of soy food intake with urinary estrogen levels in premenopausal women and in postmenopausal women have been inconsistent. We examined the associations of urinary isoflavone levels as well as soy food intake with estrone (E1) and estradiol (E2) in pre- and postmenopausal women. In addition, we compared the levels of isoflavones, E1 and E2 across current hormone users such as those receiving hormone replacement therapy and those using oral contraceptives and non-users among both pre- and postmenopausal women...
March 2019: Maturitas
Thierry K S Janssens, Olaf Tyc, Harrie Besselink, Wietse de Boer, Paolina Garbeva
Pyrazines are 1,4- diazabenzene based volatile organic compounds and known for their broad-spectrum antimicrobial activity. In the present study we assessed the antimicrobial activity of 2,5-bis(1-methylethyl)-pyrazine, produced by Paenibacillus sp. AD87 during co-culture with Burkholderia sp. AD24. In addition, we were using transcriptional reporter assays in E. coli and mammalian cells to decipher the possible mode of action. Bacterial and mammalian luciferase reporter strains were deployed to elucidate antimicrobial and toxicological effects of 2,5-bis(1-methylethyl)-pyrazine...
January 29, 2019: FEMS Microbiology Letters
Ivica Jeremic, Sasa Petricevic, Vanja Tadic, Dragana Petrovic, Jelena Tosic, Zeljka Stanojevic, Milan Petronijevic, Sasenka Vidicevic, Vladimir Trajkovic, Aleksandra Isakovic
Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast and endometrial cancer as well as a risk for cardiovascular and thromboembolic disease. Therefore, certain natural compounds with positive metabolic effects may be considered as a possible alternative or adjunctive treatment in patients not willing to take estrogens or patients with contraindications for estrogens...
January 28, 2019: Planta Medica
Neeraj Kumar Sethiya, Mohammad Raeesh Shekh, Pawan Kumar Singh
ETHNOPHARMACOLOGICAL RELEVANCE: Ensete superbum (Roxb.) Cheesman. (Family: Musaceae), commonly known as "Wild Banana" is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to India, Ethiopia, Thailand, Myanmar and Vietnam. AIM OF THE REVIEW: Despite the wide ethnomedicinal and pharmacological studies on E. superbum, there are no concise elaborated article comprising reviews of published literature...
January 24, 2019: Journal of Ethnopharmacology
Maša Knez Hrnčič, Eva Španinger, Iztok Jože Košir, Željko Knez, Urban Bren
Hop plants comprise a variety of natural compounds greatly differing in their structure and properties. A wide range of methods have been developed for their isolation and chemical analysis, as well as for determining their antioxidative, antimicrobial, and antigenotoxic potentials. This contribution provides an overview of extraction and fractionation techniques of the most important hop compounds known for their health-promoting features. Although hops remain the principal ingredient for providing the taste, stability, and antimicrobial protection of beer, they have found applications in the pharmaceutical and other food industries as well...
January 24, 2019: Nutrients
Valerie A Flores, Cheryl Leone, Hugh S Taylor, Nina S Stachenfeld
Bazedoxifene (BZA) paired with conjugated estrogens (CE) is the first tissue selective estrogen receptor complex (TSEC) approved by the United States Food and Drug Administration for the treatment of menopausal symptoms. Clinical trials in menopausal women and in premenopausal murine models of endometriosis have demonstrated safety and efficacy, however, the impact of BZA/CE on premenopausal women is not known. Here we report a case series study in premenopausal women assessing effects of BZA/CE on reproductive hormones, and uterine/ovarian ultrasonographic appearance...
January 22, 2019: Gynecological Endocrinology
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