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REVIEW
Véronique Dartois, Tracey L Bonfield, Jim P Boyce, Charles L Daley, Thomas Dick, Mercedes Gonzalez-Juarrero, Shashank Gupta, Igor Kramnik, Gyanu Lamichhane, Barbara E Laughon, Nicola I Lorè, Kenneth C Malcolm, Kenneth N Olivier, Katherine L Tuggle, Mary Jackson
Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, is increasingly recognized as an important pathogen of the human lung, disproportionally affecting people with cystic fibrosis (CF) and other susceptible individuals with non-CF bronchiectasis and compromised immune functions. M. abscessus infections are extremely difficult to treat due to intrinsic resistance to many antibiotics, including most anti-tuberculous drugs. Current standard-of-care chemotherapy is long, includes multiple oral and parenteral repurposed drugs, and is associated with significant toxicity...
March 19, 2024: Tuberculosis
#22
JOURNAL ARTICLE
Habibullah Jan, Sana Ghayas, Doaa Higazy, Nasir Mahmood Ahmad, Anan Yaghmur, Oana Ciofu
Infectious diseases, particularly those associated with biofilms, are challenging to treat due to an increased tolerance to commonly used antibiotics. This underscores the urgent need for innovative antimicrobial strategies. Here, we present an alternative simple-by-design approach focusing on the development of biocompatible and antibiotic-free nanocarriers from docosahexaenoic acid (DHA) that has the potential to combat microbial infections and phosphatidylglycerol (DOPG), which is attractive for use as a biocompatible prominent amphiphilic component of Gram-positive bacterial cell membranes...
April 26, 2024: Journal of Colloid and Interface Science
#23
JOURNAL ARTICLE
M Ali Rai, Jana Blazkova, Jesse S Justement, Victoria Shi, Brooke D Kennedy, Maegan R Manning, Mary McLaughlin, Michael C Sneller, Alice K Pau, Susan Moir, Tae-Wook Chun
BACKGROUND: People living with HIV (PLWH) with multidrug-resistant (MDR) viruses have limited therapeutic options and present challenges regarding clinical management. Recent studies have shown that passive transfer of combination broadly neutralizing antibodies (bNAbs) against HIV and anti-domain 1 CD4 antibody UB-421 can sustain virologic suppression in PLWH in the absence of antiretroviral therapy (ART). Yet studies addressing the therapeutic potential of these antibodies and/or detailed characterization of immunologic and virologic parameters in PLWH with MDR HIV are lacking...
May 9, 2024: EBioMedicine
#24
JOURNAL ARTICLE
Moussa Djimde, Charles Arama, Bouréma Koné, Hamadoun Diakité, Mohamed Keita, Mamadou D Samaké, Bréhima Tembely, Balla Bagayoko, Mohamed B Traoré, Japhet K Tshiongo, Hypolite M Mavoko, Alassane Dicko, Michel Vaillant, Petra F Mens, Henk Dfh Schallig, Kassoum Kayentao
BACKGROUND: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the health of gravidae. METHODOLOGY: This cross-sectional study was conducted in San Health District (Mali) and involved pregnant women infected or not by malaria parasites and non-pregnant healthy volunteers. Subjects were categorized as having neutropenia, normal neutrophil levels, and neutrophilia regarding their neutrophil levels...
April 30, 2024: Journal of Infection in Developing Countries
#25
JOURNAL ARTICLE
Pablo Mesa-Del-Castillo, Inés Yago Ugarte, J M Bolarín, David Martínez, Berta López Montesinos, Honorio Barranco González, Inmaculada Calvo Penadés, Lucia Lacruz Pérez, Daniel Clemente, Juan Carlos Robledillo, Isabel Valls Ferrán, Beatriz Bravo Mancheño, Marina Rubio Plats, Laura Martín Pedraz, Carmen Alba Linero, Belén Sevilla-Pérez, J L García-Serrano, Maria Concepcion Mir-Perelló, Noelia Druetta, Alex Souto, Fernando Lopez-Lopez, Cristina Zarallo-Reales, María Jerez Fidalgo, Jorge Solana Fajardo, Natalia Palmou Fontana, Rosalia Demetrio Pablo, Mari Carmen Pinedo, Alex Fonollosa, Vega Jovani Casano, Jose Juan Mondejar García, Anahy Brandy, Alba García López, M Esteban-Ortega, Teresa Reinoso, Joan Calzada-Hernández, Ana Llorca Cardeñosa, César Gavilán Martín, Encarna Mengual Verdú, Mari Paz Martínez Vidal, Neus Quilis Martí, M C Alvarado, Jaime De Inocencio, Beatriz Alonso-Martín, Sheila Recuero-Diaz, Ester Carreño, Juan Carlos Nieto González, Lucia Ibares, Jose Rosas Gómez de Salazar, Juan Luis Sánchez Sevila
OBJECTIVE: To characterize and describe clinical experience with childhood-onset non-infectious uveitis. STUDY DESIGN: A multicenter retrospective multidisciplinary national web-based registry of 507 patients from 21 hospitals was analyzed. Cases were grouped as immune disease-associated (IMDu), idiopathic (IDIu) or ophthalmologically distinct. Characteristics of juvenile idiopathic arthritis-associated (non-HLA-B27-related) uveitis (JIAu), IDIu, and pars planitis (PP) were compared...
May 10, 2024: Ocular Immunology and Inflammation
#26
JOURNAL ARTICLE
Mathis Mottelson, Andreas Glenthøj, Børge Grønne Nordestgaard, Christina Ellervik, Jesper Brix Petersen, Stig Egil Bojesen, Jens Helby
It is unclear whether risk of infection is increased in individuals with hereditary haemochromatosis and in individuals with low or high plasma iron, transferrin saturation, or ferritin. Therefore, we tested whether high and low iron, transferrin saturation, and ferritin are associated with risk of infections observationally and genetically through HFE genotypes. We studied 142,188 Danish general population individuals. Iron, transferrin saturation, and ferritin were measured in 136,656, 136,599, and 38,020 individuals, respectively...
May 10, 2024: Blood
#27
JOURNAL ARTICLE
Oscar A Fernández-García, Cristina Hernandez, Mark Robbins, Dima Kabbani, Karen Doucette, Carlos Cervera
BACKGROUND: Cytomegalovirus (CMV) mismatched, donor IgG-positive/recipient IgG-negative, solid organ transplant recipients (SOTRs) are at high risk of CMV invasive disease. Post-prophylaxis disease is an issue in this population. Some programs employ surveillance after prophylaxis (SAP) to limit the incidence of post-prophylaxis disease. METHODS: This was a single-center retrospective cohort study that included all CMV mismatched SOTRs from 2003 to 2017. Patients underwent SAP with weekly CMV plasma viral load for 12 weeks...
May 10, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#28
Clazinus Veijer, Marinus H van Hulst, Benjamin Friedrichson, Maarten J Postma, Antoinette D I van Asselt
BACKGROUND: Following clinical research of potential coronavirus disease 2019 (COVID-19) treatments, numerous decision-analytic models have been developed. Due to pandemic circumstances, clinical evidence was limited and modelling choices were made under great uncertainty. This study aimed to analyse key methodological characteristics of model-based economic evaluations of COVID-19 drug treatments, and specifically focused on modelling choices which pertain to disease severity levels during hospitalisation, model structure, sources of effectiveness and quality of life and long-term sequelae...
May 10, 2024: PharmacoEconomics
#29
REVIEW
Giuseppe Danilo Cassano, Lorenzo Moretti, Giovanni Vicenti, Claudio Buono, Federica Albano, Teresa Ladogana, Igor Rausa, Angela Notarnicola, Giuseppe Solarino
Infection is an uncommon side effect of arthroscopic surgery, and this percentage is higher in anterior cruciate ligament reconstruction (ACLR) surgery, where graft and fixation devices are used. Infections can not only lead to high re-admission rates and poor functional recovery of the knee but can also have a significant negative impact on the patient's psychological and economic health, especially in athletes, as it can affect their sports career. It is important to be aware of the many risk factors, especially the manifestation of symptoms...
April 25, 2024: Healthcare (Basel, Switzerland)
#30
Bangtao Li, Weiming Chen, Xiaodi Cai, Yuanping Hai, Qiming Pang, Wei Xiang, Zhengzheng Zhang
X-linked lymphoproliferative disease (XLP) is a rare genetic disorder characterized by immune dysregulation. The three most common clinical phenotypes are EBV-associated infectious mononucleosis (FIM), abnormal gammaglobulinemia, and lymphoma. We present a rare case of XLP1 with neurovasculitis, which is non-EBV-related and involves multiple systems, a condition rarely seen in children. The patient initially presented with an unsteady gait, which progressively evolved into language and consciousness disorders...
2024: Frontiers in Immunology
#31
Narges Lashkarbolouk, Mahdi Mazandarani
KEY CLINICAL MESSAGE: Common cardiac arrhythmias seen in patients with leptospirosis are usually atrial fibrillation or first-degree atrioventricular block, with bradyarrhythmia being rare in this group. It is essential to prioritize the examination of the patient's medical background, clinical symptoms, and comprehensive physical evaluation in order to promptly identify and address the patient's condition. ABSTRACT: Leptospirosis, a zoonotic disease that is widespread worldwide, has a significant impact on tropical areas and can affect various organs throughout the infection...
May 2024: Clinical Case Reports
#32
Jihan M Muhaidat, Enas A Alhaje, Firas A Al-Qarqaz, Diala M Alshiyab, Almutazballlah Bassam Qablan
Idiopathic granulomatous vulvitis is an uncommon anogenital area disease described in the last few decades. It causes an inflammatory reaction that culminates in swelling and possibly distortion of the female anogenital area. Many reported cases consider this non-infectious entity the genital counterpart to granulomatous cheilitis. We here present a 64 years old female patient with idiopathic granulomatous vulvitis co-existing with lipodermatosclerosis, with the excellent response of the former condition to hydroxychloroquine and potent topical steroids...
2024: Clinical Medicine Insights. Case Reports
#33
JOURNAL ARTICLE
Challa Anil Kumar, Satyanarayana Kummari, Bagadi Lava Kumar
Background The phrase "compressive myelopathy" refers to compression of the spinal cord, either internally or externally. This compression might arise from various sources such as a herniated disc, post-traumatic compression, and epidural abscess as well as epidural or intradural neoplasms. Magnetic resonance imaging (MRI) plays a crucial role in differentiating between compressive and non-compressive myelopathy. After eliminating compressive lesions, attention is directed toward intrinsic cord-related causes of acute myelopathy including vascular, infectious, and inflammatory pathologies...
April 2024: Curēus
#34
JOURNAL ARTICLE
Xiao Wang, Huiye Zhang, Nan Zhang, Shan Zhang, Yanrong Shuai, Xiaojuan Miao, Yilan Liu, Ling Qiu, Shihui Ren, Sihan Lai, Ying Han, Hao Yao, Xupai Zhang, Fangyi Fan, Haoping Sun, Hai Yi
BACKGROUND: Metagenomic next-generation sequencing (mNGS) is a novel non-invasive and comprehensive technique for etiological diagnosis of infectious diseases. However, its practical significance has been seldom reported in the context of hematological patients with high-risk febrile neutropenia, a unique patient group characterized by neutropenia and compromised immune responses. METHODS: This retrospective study evaluated the results of plasma cfDNA sequencing in 164 hematological patients with high-risk febrile neutropenia...
2024: Frontiers in Cellular and Infection Microbiology
#35
JOURNAL ARTICLE
Xingxing Zhang, Liuyang Yang, Teng Chen, Qing Wang, Jin Yang, Ting Zhang, Jiao Yang, Hongqing Zhao, Shengjie Lai, Luzhao Feng, Weizhong Yang
BACKGROUND: Influenza is an acute respiratory infectious disease with a significant global disease burden. Additionally, the coronavirus disease 2019 pandemic and its related non-pharmaceutical interventions (NPIs) have introduced uncertainty to the spread of influenza. However, comparative studies on the performance of innovative models and approaches used for influenza prediction are limited. Therefore, this study aimed to predict the trend of influenza-like illness (ILI) in settings with diverse climate characteristics in China based on sentinel surveillance data using three approaches and evaluate and compare their predictive performance...
September 2024: Infectious Disease Modelling
#36
JOURNAL ARTICLE
Alan de Paula Mozella, Hugo Alexandre de Araujo Barros Cobra, Idemar Monteiro da Palma, Rodrigo Salim, João Antonio Matheus Guimarães, Gilson Costa, Ana Carolina Leal
Periprosthetic joint infection (PJI) is one of the most challenging complications following total knee arthroplasty. Despite its importance, there is a paucity of reports in the literature regarding its pathogenesis. Recently, cellular metabolic reprogramming has been shown to play an important role in the progression and outcome of infectious diseases. Therefore, the aim of this study was to evaluate the metabolites composition of the synovial fluid from patients with PJI or aseptic failure of total knee arthroplasties...
May 10, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#37
REVIEW
José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro, Henrique Douglas Melo Coutinho
ETHNOPHARMACOLOGICAL RELEVANCE: Popularly known as "penicilina" and "terramicina", Alternanthera brasiliana (L.) Kuntze belongs to the Amaranthaceae family and stands out for its ethnomedicinal uses in the treatment of infections caused by pathogenic microorganisms in some countries. AIM OF THE STUDY: The present study aimed to carry out a literature review and analyze whether the scientific evidence really validates the numerous indications for the use of A. brasiliana in traditional medicine for the treatment of infectious diseases...
May 7, 2024: Journal of Ethnopharmacology
#38
JOURNAL ARTICLE
Leyi Zhang, Yongqiang Shao, Yi Li, Shengkai Li, Huihuang Lou, Yuqin Hu, Panchi Shao, Xuewei Liu, Yuejin Wu, Yuwen Zhang, Tiejun Song, Lei Fang
OBJECTIVES: To investigate cases of five Campylobacter jejuni outbreaks and describe laboratory characteristics of these infections. METHODS: Whole genome sequencing and conventional methods were combined to thoroughly investigate the outbreaks, and data of contemporaneous sporadic cases was included for comparison. RESULTS: Seven sequence types (ST) of C. jejuni caused 83 cases, including ST9079 which recurred across two years. Trace-back investigation could not identify any food items of infection, but detected identical campylobacters from food contacts...
May 7, 2024: International Journal of Infectious Diseases: IJID
#39
JOURNAL ARTICLE
Ethan Mabvuto Zulu, Julie M Herlihy, Cassandra R Duffy, Lawrence Mwananyanda, Roma Chilengi, Leah Forman, Tim Heeren, Christopher J Gill, Roy Chavuma, Barbara Payne-Lohman, Donald M Thea
INTRODUCTION: There have been few empirical studies for diagnostic test accuracy of syphilis using a sequence of rapid tests in populations with low prevalence of syphilis such as pregnant women. This analysis describes syphilis test positivity frequency among pregnant women at an antenatal clinic in Zambia using a reverse-sequence testing algorithm for antenatal syphilis screening. METHODS: Between August 2019 and May 2023, we recruited 1510 pregnant women from a peri-urban hospital in Lusaka, Zambia...
2024: PloS One
#40
JOURNAL ARTICLE
Giuseppe Parrella, Benoit Moury
Tobacco vein necrosis (TVN) is a complex phenomenon regulated by different genetic determinants mapped in the HC-Pro protein (amino acids N330, K391 and E410) and in two regions of potato virus Y (PVY) genome, corresponding to the cytoplasmic inclusion (CI) protein and the nuclear inclusion protein a-protease (NIa-Pro), respectively. A new determinant of TVN was discovered in the MK isolate of PVY which, although carried the HC-Pro determinants associated to TVN, did not induce TVN. The HC-Pro open reading frame (ORF) of the necrotic infectious clone PVY N605 was replaced with that of the non-necrotic MK isolate, which differed only by one amino acid at position 392 (T392 instead of I392)...
2024: PloS One
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