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Yan Geng, Xue Liu, Jiurong Liang, David M Habiel, Kulur Vrishika, Ana Lucia Coelho, Nan Deng, Ting Xie, Yizhou Wang, Ningshan Liu, Guanling Huang, Adrianne Kurkciyan, Zhenqiu Liu, Jie Tang, Cory M Hogaboam, Dianhua Jiang, Paul W Noble
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular matrix deposition, leading to a distortion of pulmonary architecture and impaired gas exchange. Fibroblasts from IPF patients acquire an invasive phenotype that is essential for progressive fibrosis. Here, we performed RNA-seq analysis on invasive and non-invasive fibroblasts and found that the immune checkpoint ligand CD274 (PD-L1) was up-regulated on invasive lung fibroblasts and was required for the invasive phenotype of lung fibroblasts, is regulated by P53 and FAK, and drives lung fibrosis in a humanized IPF model in mice...
February 14, 2019: JCI Insight
Cory P Poehling, Tamra L Llewellyn
The purpose of this study was to examine heart rate variability (HRV) at rest, and during submaximal (100 bpm) and maximal exercise in collegiate distance runners. We predicted there would be less HRV during exercise. Eight collegiate runners (19-22 yrs) were recruited for participation. The participants were equipped with a standard Lead II EKG to record HRV at rest. The participants then performed an incremental VO2max test while running on a treadmill. EKG was recorded throughout the exercise test and HRV was later calculated during the submaximal and maximal exercise...
2019: International Journal of Exercise Science
Magdalena Blaszkiewicz, Jake W Willows, Cory P Johnson, Kristy L Townsend
Brown and white adipose tissues are essential for maintenance of proper energy balance and metabolic health. In order to function efficiently, these tissues require both endocrine and neural communication with the brain. Brown adipose tissue (BAT), as well as the inducible brown adipocytes that appear in white adipose tissue (WAT) after simulation, are thermogenic and energy expending. This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine. In addition to sympathetic noradrenergic signaling, adipose tissue contains sensory nerves that may be important for relaying fuel status to the brain...
February 12, 2019: Biology
Jakub Godzik, Corey T Walker, Cory Hartman, Bernardo de Andrada, Clinton D Morgan, George Mastorakos, Steven Chang, Jay Turner, Randall W Porter, Laura Snyder, Juan Uribe
BACKGROUND: Minimally invasive surgery (MIS) and anterior (ALIF), transforaminal (TLIF), or lateral lumbar interbody fusion (LLIF) often require percutaneous pedicle screw fixation (PSF) to achieve circumferential fusion. Robotic guidance technology may augment workflow to improve screw placement and decrease operative time. OBJECTIVE: To report surgical experience with robotically assisted percutaneous screw placement following LLIF. METHODS: Data from fusions with robotically assisted PSF in prone or lateral decubitus positions was reviewed...
February 6, 2019: Operative Neurosurgery (Hagerstown, Md.)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Cory D Sago, Zubao Gan, Melissa P Lokugamage, Fatima Z Islam, Sujay Kalathoor, Brandon R Krupczak, James E Dahlman
Using mRNA to produce therapeutic proteins is a promising approach to treat genetic diseases. However, systemically delivering mRNA to cell types besides hepatocytes remains challenging. Fast identification of nanoparticle delivery (FIND) is a DNA barcode-based system designed to measure how over 100 lipid nanoparticles (LNPs) deliver mRNA that functions in the cytoplasm of target cells in a single mouse. By using FIND to quantify how 75 chemically distinct LNPs delivered mRNA to 28 cell types in vivo, it is found that an LNP formulated with oxidized cholesterol and no targeting ligand delivers Cre mRNA, which edits DNA in hepatic endothelial cells and Kupffer cells at 0...
February 12, 2019: Advanced Materials
Kjirsten Carlson, Alice Chung, James Mirocha, Cory Donovan, Sylvia Estrada, Emily Siegel, Armando Giuliano, Farin Amersi
Outcomes based on menopausal status of breast cancer (BC) patients who are BRCA mutations carriers (BRCAm) are not well known. A prospective database identified 88 BRCAm with BC from 2005 to 2015. Of the 88 patients, 68 (77.3%) women were premenopausal (Pre-M) and 20 (22.7%) were postmenopausal (Post-M). In the Pre-M group, 52.9 per cent of patients had triple-negative (TN) BC, whereas in the Post-M group, there were more estrogen receptor +(65%; P = 0.129) and less TN (25%; P = 0.041) tumors. Median tumor size was significantly larger in the Pre-M group compared with the Post-M group ( P <0...
October 1, 2018: American Surgeon
Wesley E Barry, Erica N Barin, Lori C Marshall, Majella Doherty, Eugene Nguyen, Cory McLaughlin, Lucas Kaplan, James E Stein, Aaron R Jensen
Apprehension in taking independent care of children with medical devices may lead to unnecessary visits to the ED and/or acute clinic (AC). To address these concerns, our institution implemented a gastrostomy tube (GT) class in 2011 for caretakers. We hypothesized that inappropriate GT-related ED/AC visits would be lower in preoperatively educated caregivers. We performed a retrospective cohort study of all patients aged 0 to 18 who received GT (surgical or percutaneous) at our institution between 2006 and 2015 (n = 1340)...
October 1, 2018: American Surgeon
Inmaculada Jarrin, Ines Suarez-Garcia, Cristina Moreno, Maria Tasias, Jorge Del Romero, Rosario Palacios, Joaquim Peraire, Miguel Gorgolas, Santiago Moreno
BACKGROUND: We compared time to treatment change (TC), viral suppression (VS) and change in CD4+ T-cell counts of first-line antiretroviral regimens (ART). METHODS: We analyzed HIV treatment-naïve adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) initiating the most commonly used ART regimens from September 2014 to November 2015. We used proportional hazards models on the sub-distribution hazard to estimate sub-distribution hazard ratios (sHR) for time to TC, logistic regression to estimate odds ratios (ORs) for VS (viral load<50 copies/ml), and linear regression to assess mean differences in CD4 changes from ART initiation...
February 12, 2019: Antiviral Therapy
Massimiliano Sorbello, Gerardo Cortese, Cory Gaçonnet, Marcus Skinner
No abstract text is available yet for this article.
January 2019: Indian Journal of Anaesthesia
Nadejda Beliakova-Bethell, Amey Mukim, Cory H White, Savitha Deshmukh, Hosiana Abewe, Douglas D Richman, Celsa A Spina
Histone deacetylase (HDAC) inhibitors (HDACi) have been widely tested in clinical trials for their ability to reverse HIV latency, but have yielded only limited success. One HDACi, suberoylanilide hydroxamic acid (SAHA), exhibits off-target effects on host gene expression predicted to interfere with induction of HIV transcription. Romidepsin (RMD) has higher potency and specificity for class I HDACs implicated in maintaining HIV provirus in the latent state. More robust HIV reactivation has indeed been achieved with RMD use ex vivo than with SAHA; however, reduction of viral reservoir size has not been observed in clinical trials...
February 11, 2019: Journal of Biological Chemistry
Cori Lorts, Natasha Tasevska, Marc A Adams, Michael J Yedidia, David Tulloch, Steven P Hooker, Punam Ohri-Vachaspati
BACKGROUND: The United States Department of Agriculture's Supplemental Nutrition Assistance Program (SNAP) is the country's largest nutrition assistance program for low-income populations. Although SNAP has been shown to reduce food insecurity, research findings on the diet quality of program participants are inconsistent. OBJECTIVE: This study evaluated whether the community food environment is a potential moderator of the association between SNAP participation and eating behaviors...
February 7, 2019: Journal of the Academy of Nutrition and Dietetics
Cory K Chen, Amy Palfrey, Erica Shreck, Brittney Silvestri, Lauren Wash, Nicole Nehrig, Alyssa L Baer, Jennifer A Schneider, Sagiv Ashkenazi, Scott E Sherman, Joshua Chodosh
Meeting the mental health needs of our current veteran population is one of the primary challenges facing the Veteran's Health Administration (VHA). Particularly for veterans residing in rural areas, the lack of providers, high provider turnover, and the burden of traveling long distances to VHA facilities may contribute to difficulties accessing mental health care. Telemental Health (TMH) services help bridge the geographic gap between mental health providers and veterans who need mental health services. The VHA TMH Hub initiative has attempted to leverage changes in technology-facilitated care by developing a model in which a facility "hub" could expand mental health resources to remote "spoke" clinics and veterans' residences...
February 11, 2019: Psychological Services
Carlos Calvache, Marco Guzman, Marcelo Bobadilla, Cori Bortnem
PURPOSE: The present study aimed at observing the possible differential effects of eight semioccluded vocal tract exercises (SOVTE) on vocal economy measured by the Quasi Output Cost Ratio (QOCR). METHODS: Thirty-six participants were included in this study. They were divided into two groups: an experimental group of subjects diagnosed with mild hyperfunctional dysphonia (n = 17) and a control group of vocally healthy subjects (n = 19). Participants were required to randomly select and produce a series of three SOVTE from a list of eight exercises...
February 6, 2019: Journal of Voice: Official Journal of the Voice Foundation
Patricio Riva-Posse, Cory S Inman, Ki Sueng Choi, Andrea L Crowell, Robert E Gross, Stephan Hamann, Helen S Mayberg
BACKGROUND: Subcallosal cingulate deep brain stimulation (SCC DBS) is an experimental treatment for severe depression. Surgery is performed with awake patients and intraoperative stimulation produces acute behavioral responses in select contacts. While there have been reports on the relationship between acute intraoperative behaviors and their relation to the location of the contacts, there are no descriptions of the physiological changes that accompany them. OBJECTIVE: The present study sought to examine these physiological readouts, and their association with the anatomical substrates that generated them...
January 26, 2019: Brain Stimulation
Cory M Pfeifer
No abstract text is available yet for this article.
February 6, 2019: Journal of the American College of Radiology: JACR
Ethan C Hill, Terry J Housh, Joshua L Keller, Cory M Smith, Richard J Schmidt, Glen O Johnson
INTRODUCTION: The purpose of this investigation was to examine the ability of the electromyographic (EMG) and mechanomyographic (MMG) amplitude versus torque relationships to track group and individual changes in muscle hypertrophy as a result of resistance training. METHODS: Twelve women performed four weeks of forearm flexion blood flow restriction (BFR) resistance training at a frequency of three times per week. The training was performed at an isokinetic velocity of 120°·s-¹ with a training load that corresponded to 30% of concentric peak torque...
February 8, 2019: Physiological Measurement
Shannon R Escasa, Robert L Harrison, Joseph D Mowery, Gary R Bauchan, Jenny S Cory
Spodoptera exempta nucleopolyhedrovirus (SpexNPV) is a viral pathogen of the African armyworm, Spodoptera exempta (Lepidoptera: Noctuidae), a significant agricultural pest of cereal crops in Africa. SpexNPV has been evaluated as a potential insecticide for control of this pest and has served as the subject of research on baculovirus pathology and transmission. Occlusion bodies (OBs) of SpexNPV isolate 244.1 were examined, and the nucleotide sequence of the genome was determined and characterized. SpexNPV-244...
2019: PloS One
Seema Bhatlekar, Indranil Basak, Leonard C Edelstein, Robert A Campbell, Cory R Lindsey, Joseph E Italiano, Andrew S Weyrich, Jesse W Rowley, Matthew T Rondina, Martha Sola-Visner, Paul F Bray
Apoptosis is a recognized limitation for generating large numbers of megakaryocytes in culture. The responsible apoptosis genes have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems. As CD34+ cells isolated from human umbilical vein cord blood were differentiated into megakaryocytes in culture, two distinct cell populations were identified by flow cytometric forward and side scatter: larger size, lower granularity and smaller size, higher granularity. The larger size, lower granularity cells were CD41aHighCD42aHighphosphatidylserineLow, had an electron microscopic morphology similar to mature bone marrow megakaryocytes, developed proplatelets, and displayed a signaling response to platelet agonists...
February 7, 2019: Haematologica
Cory E Cronin, Berkeley Franz, Daniel Skinner, Zelalem T Haile
OBJECTIVE: To test whether the opioid epidemic increased hospitals' offerings of substance use services. DATA SOURCES/STUDY SETTING: This study employs data from the 2010 and 2015 American Hospital Association Annual Survey. STUDY DESIGN: A multilevel, cross-sectional design was utilized to examine associations between county-level overdose rates and hospital substance use services. DATA COLLECTION/EXTRACTION METHODS: The analytic sample consisted of 3365 acute care hospitals that answered pertinent survey questions...
February 5, 2019: Health Services Research
Elham Hatami, Ying Mu, Deanna N Shields, Subhash C Chauhan, Santosh Kumar, Theodore J Cory, Murali M Yallapu
Our goal was to design nanocarriers that specifically target and deliver therapeutics to polarized macrophages. Mannose receptors are highly overexpressed on polarized macrophages. In this study, we constructed Pluronic® -F127 polymer and tannic acid (TA) based nanoparticles (F127-TA core nanoparticles) with varying mannose densities. The particle size of the optimized mannose-decorated F127-TA hybrid nanoparticles (MDNPs) was found to be ~ 265 nm with a negative zeta potential of ~ - 4.5 mV. No significant changes in the size and zeta potentials of nanoparticles were observed, which demonstrated structural integrity and stability of the nanoformulation...
March 2019: Biochemistry and Biophysics Reports
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