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J-W Feng, X-H Yang, B-Q Wu, D-L Sun, Y Jiang, Z Qu
BACKGROUND: Central lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is common. But the association between primary tumor characteristics and specific features of metastatic lymph nodes in PTC has not been fully identified. Determining risk factors for LNM may help surgeons determine rational extent of lymph node dissection. METHODS: Data from 432 patients who underwent thyroidectomy with cervical lymph node dissection for PTC were retrospectively analyzed...
March 16, 2019: Clinical & Translational Oncology
Patrizia Straccia, Chiara Brunelli, Esther D Rossi, Paola Lanza, Maurizio Martini, Teresa Musarra, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda
BACKGROUND: The recently introduced monoclonal V600E antibody (clone VE1) is likely to be an alternative strategy for detecting this mutation in thyroid lesions. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in cytology and cell block samples is rarely performed, and its diagnostic value in cytology has not been well established. In this study, we sought to determine if VE1 is suitable for FNA and cell block method...
March 15, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
Vivian Y Park, Kyunghwa Han, Eunjung Lee, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
Patients with papillary thyroid carcinoma (PTC) would benefit from risk stratification tools that can aid in planning personalized treatment and follow-up. The aim of this study was to develop a conventional ultrasound (US)-based radiomics signature to estimate disease-free survival (DFS) in patients with conventional PTC. Imaging features were extracted from the pretreatment US images of 768 patients with conventional PTC who were treated between January 2004 and February 2006. The median follow-up period was 117...
March 14, 2019: Scientific Reports
Shulong Zhang, Quan Wang, Qi Han, Huazhong Han, Pinxiang Lu
The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. This study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from GEO database. The differentially expressed genes (DEGs) between PTC tissues and matched non-cancerous tissues were identified using GEO2R tool. The common DEGs in the two datasets were screened out by VennDiagram package, and analyzed by the following tools: KOBAS, DAVID, STRING, UALCAN and GEPIA...
March 14, 2019: Bioscience Reports
Feng Wu, Fuxingzi Li, Xiao Lin, Feng Xu, Rongrong Cui, Jiayu Zhong, Ting Zhu, Su-Kang Shan, Xiao-Bo Liao, Lingqing Yuan, Zhaohui Mo
Tumour-derived exosomes under hypoxic conditions contain informative microRNAs involved in the interaction of cancer and para-carcinoma cells, thus contributing to tissue remodelling of the tumour microenvironment (TME). Exosomes isolated from hypoxic papillary thyroid cancer cells, BCPAP cells and KTC-1 cells, enhanced the angiogenesis of human umbilical vein endothelial cells (HUVECs) compared with exosomes isolated from normal thyroid follicular cell line (Nthy-ori-3-1), normoxic BCPAP cells or KTC-1 cells both in vitro and vivo...
March 1, 2019: Endocrine-related Cancer
Ju Hye Jeong, Ji Min Oh, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Background Vemurafenib is a selective BRAF inhibitor (BRAFi) that has shown promising activity in BRAFV600E-positive papillary thyroid cancer (PTC). However, adverse events and resistance to a single-agent BRAFi often require discontinuation of the targeted therapy in BRAFV600E-positive PTC. Thus, we investigated the expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) family members, which is frequently overexpressed in many human cancers to inhibit apoptosis, in PTC harboring the BRAFV600E mutation after BRAFi treatment and then evaluated the cytotoxic effects of a homology 3 domain (BH3)-mimetic in combination with a BRAFi...
March 14, 2019: Thyroid: Official Journal of the American Thyroid Association
W Ye, X Deng, Y Fan
Exosomes are considered important "messengers" between cells and their cargo, and some of the miRNAs composing their cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated in gastric cancer and associated with its poor prognosis. However, the role of exosome-derived miRNAs in papillary thyroid cancer (PTC) is still unclear and needs further study. In our work, we found that the level of Ex-miRNA423-5p was significantly increased in the serum of PTC patients compared with the serum of normal healthy people, and in vitro, we demonstrated that miRNA423-5p entered thyroid cancer cells through exosomes from thyroid cancer cell supernatant...
March 7, 2019: Neoplasma
Bita Geramizadeh, Zahra Maleki
BACKGROUND: The nomenclature "Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features (NIFTP)" was introduced in 2016. While NIFTP differs from classic papillary thyroid carcinoma (PTC) in imaging, cytomorphology, histology, molecular profile, treatment, follow up, outcome, and behavior, it largely overlaps with follicular variant of PTC at imaging and cytomorphology. Herein, we review the literature for better understanding NIFTP, and its impact on patient care...
March 13, 2019: Endocrine
Nicolas Guignard, Guillaume Chambon, Benjamin Chambert, Yaser Najaf, Benjamin Lallemant
PURPOSE: Characterization of thyroid nodules is crucial to propose surgical intervention for histological verification. Cervical ultrasound potentially combined with fine needle aspiration is recommended, and fluorocholine positron emission tomography (FCH-PET), commonly used in prostatic cancers, has been evaluated in the diagnosis of thyroid cancers in recent publications. METHODS: We present two cases of patients with multinodular thyroid and primary hyperparathyroidism...
March 14, 2019: European Archives of Oto-rhino-laryngology
Jiaqi Xie, Yi Liu, Xiaolong Du, Ying Wu
Increased expression levels of transforming growth factor-β1 (TGF-β1) are associated with metastasis in papillary thyroid carcinoma (PTC), although the mechanisms involved remain unknown. The present study aimed to investigate these mechanisms. The results demonstrated that the expression levels of TGF-β1 mRNA were higher and those of lncRNA-NEF were lower in tumor tissues compared with in healthy tissues. High levels of TGF-β1 mRNA and low levels of lncRNA-NEF were also detected in the serum of patients with PTC compared with in healthy controls...
March 2019: Oncology Letters
Takashi Koshikawa, Nao Fujita, Nanae Ueda, Yuko Ota, Eiichi Sasaki, Yoshiko Murakami, Waki Hosoda, Yasushi Yatabe, Nobuhiro Hanai, Miyoko Higuchi, Mitsuyoshi Hirokawa, Akira Miyauchi
We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly noninvasive FVPTC) to identify useful cytological parameters for their differentiation. Cytological findings of invasive FVPTC and NIFTP were very similar to each other but differed from those of conventional PTC. Intranuclear cytoplasmic inclusions, true papillary cell clusters, monolayered cell sheets, ropy colloids, multinucleate giant cells, psammoma bodies, and cystic background were the observed characteristic features of conventional PTC...
March 14, 2019: Endocrine Journal
Mara Ventura, Miguel Melo, Graça Fernandes, Francisco Carrilho
OBJECTIVES: Non-invasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). We aimed to compare the risk of malignancy (ROM) of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) on fine-needle aspiration cytology (FNAC), before and after the reclassification, in a large cohort of patients. METHODS: We analyzed 5...
March 13, 2019: Endocrine Practice
Hye-Seon Oh, Hyemi Kwon, Eyun Song, MinJi Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, YoungKee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
<i><b>Background</b></i> Tumor volume (TV) of papillary thyroid carcinoma (PTC) increases exponentially during active surveillance and the growth rate differs for each patient. TV doubling time (TVDT) is considered as a strong dynamic marker for the prediction of growth rate and progression of the tumor. <b><i>Methods</i></b> In this cohort study, we analyzed 273 PTC patients who underwent active surveillance for over one year rather than immediate thyroid surgery...
March 13, 2019: Thyroid: Official Journal of the American Thyroid Association
Grayce Ellen da Cruz Paiva Lima, Virgínia Oliveira Fernandes, Ana Paula Dias Rangel Montenegro, Annelise Barreto de Carvalho, Lia Beatriz de Azevedo Sousa Karbage, Lindenberg Barbosa Aguiar, Mário Sérgio Rocha Macedo, Luis Alberto Albano Ferreira, Renan Magalhães Montenegro Júnior
Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Here, we reported a rare case of a type 2 CGL in a girl who presented with a papillary TC (PTC) at the age of 7 years...
February 2019: Archives of Endocrinology and Metabolism
Ana Rafaela Lopes Reis Lima, Karoline Matias Morais de Medeiros, Conceição de Maria Ribeiro Veiga Parente, Adriana de Sá Caldas, Manuel Dos Santos Faria, Marcelo Magalhães, Carla Souza Pereira Sobral
OBJECTIVE: To analyze the importance of preoperative cytology of thyroid nodules and its relationship with mortality risk, recurrence risk, dynamic stratification, and aggressive characteristics (vascular invasion, aggressive histology, incomplete tumor resection, extrathyroidal extension of the tumor, and presence of lymph node and distant metastases). SUBJECTS AND METHODS: Retrospective evaluation of 153 patients diagnosed with differentiated thyroid carcinoma (DTC) and following up at the Hospital Universitário Presidente Dutra between January 1999 and December 2016...
February 2019: Archives of Endocrinology and Metabolism
Carla Fernanda Nava, André B Zanella, Rafael Selbach Scheffel, Ana Luiza Maia, Jose Miguel Dora
OBJECTIVE: The 8th TNM system edition (TNM-8) released in 2018 presents significant changes when compared to the 7th edition (TNM-7). The aim of this study was to assess the impact of changing the TNM staging criteria on the outcomes in a Brazilian cohort of differentiated thyroid carcinoma (DTC). SUBJECTS AND METHODS: DTC patients, attending a tertiary, University-based hospital, were classified by TNM-7 and TNM-8. Prediction of disease outcomes status of the two systems was compared in a retrospective cohort study design...
February 2019: Archives of Endocrinology and Metabolism
Bo Lin, Hong-Yu Yang, Hui-Jun Yang, Shi-Yue Shen
BACKGROUND: Paraganglioma/pheochromocytoma and medullary thyroid carcinoma can coexist and are often found in multiple endocrine neoplasia (MEN). However, very few cases highlight papillary thyroid carcinoma. We present herein a rare case of head and neck paraganglioma associated with papillary thyroid carcinoma. CASE SUMMARY: A 51-year-old man presented to our department with right-sided neck swelling and hypertension. Physical examination showed neck masses with obvious pulsation...
March 6, 2019: World Journal of Clinical Cases
Warut Pongsapich, Cheerasook Chongkolwatana, Naravat Poungvarin, Kanchana Amornpichetkul, Nutthaya Piyawattayakorn, Pichpisith Vejvisithsakul, Prachya Maneeprasopchoke
Purpose: Fine-needle aspiration biopsy (FNAB) is regarded by the Bethesda system as the gold-standard investigation for stratifying the risk of malignancy of a thyroid nodule. However, some limitations affect the adequacy of the obtained materials, resulting in 30% of the cytological results remaining in the indeterminate category. We aimed to investigate the diagnostic value of the BRAF mutation in cytologically indeterminate thyroid nodules after the reclassification of a variant thyroid carcinoma...
2019: OncoTargets and Therapy
Na Li, Mingming Cui, Ping Yu, Qiang Li
Background: Cervical lymph node metastasis is an important prognostic indicator for papillary thyroid carcinoma (PTC) and affects treatment strategies for PTC. lncRNAs essentially contribute to the biological functions of tumors. This study aimed to identify the lncRNAs associated with cervical lymph node metastasis and prognosis of PTC and their potential pathophysiological mechanisms. Materials and methods: PTC-associated lncRNAs were selected from The Cancer Genome Atlas database, and correlations among lncRNAs, lymph node metastasis, tumor staging, and prognosis of PTC were analyzed in silico...
2019: OncoTargets and Therapy
Roberta Esposito, Daniela Esposito, Alfredo Ciccodicola, Valerio Costa
RET rearrangements as well as BRAF and RAS mutations drive differential pathway activation in papillary thyroid carcinomas, leading to different tumor phenotypes and prognoses. Although The Cancer Genome Atlas Consortium has identified tumor subgroups based on protein-coding gene signatures, neither expression of long non-coding RNAs (lncRNAs) nor their correlation with specific tumor-driving mutations and rearrangements have been systematically assessed. Here we reanalyzed our RNA-sequencing data using a de novo discovery approach to identify lncRNAs and define tumor subtype-specific signatures of annotated lncRNAs...
March 12, 2019: Cancer Research
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